Protein Alignment KRT8 and ifa-3

DIOPT Version :10

• Sequence 1: NP_001243211.1
• Gene: KRT8 / 3856
• HGNCID: 6446
• Length: 511
• Species: Homo sapiens
• Sequence 2: NP_510649.3
• Gene: ifa-3 / 181699
• WormBaseID: WBGene00002051
• Length: 581
• Species: Caenorhabditis elegans
• Alignment Length: 533
• Identity: 113/533 - (21%)
• Similarity: 231/533 - (43%)
• Gaps: 113/533 - (21%)

Human    23 STPASTMSIRVTQKSYKVSTSGPRAFS--SRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGA 85
            |.||...::..:.::|....||.|...  :.::||...|.:|..                |.|.|
 Worm    13 SRPAFNRTVTSSTQNYGTPASGNRVLKIVTETHTSSVASGLSPY----------------GQGAA 61

Human    86 SGMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETK 150
            |                        .|:..|.:||::|..||::.||:|.|||||..||:.||..
 Worm    62 S------------------------TIRDDREREKKEITELNDRLASYIGKVRFLAAQNRKLEAD 102

Human   151 WSLLQQQ-KTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYED----- 209
            .::||.: ..:..::..|:|..|......::..|::..:.|.|:|.::..:::.:.|:|:
 Worm   103 LNVLQSRFGKSTGSVKIMYEMEITTATNVVKETGKDHEEAEKEIGKIKDQLDELRKKFEEAQKGR 167

Human   210 -------------------EIN-------------KRTEMEN-----EFVLIKKDVDEAYMNKVE 237
                               |||             .|.:.||     |...::.::|:..:.:::
 Worm   168 AEDRLKIDELLVTLSNLEAEINLLKRRIALLEEEVARLKKENFRLTSELQRVRSELDQETLLRID 232

Human   238 LESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRS 302
            .::::..:.:||:|:::.:|.|:::||:|.:..:...:.:..::..|:| |.:::|:|:.....:
 Worm   233 NQNKVTTILEEIDFMKRGFETELKDLQAQAARDTTSENREYFKNELMNS-IRDIRAEYDRFMAGN 296

Human   303 RAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAE 367
            |.:.||..||:.:|:.:...:...::...:.|:..::..:|.|:::...|..:...||..:.|..
 Worm   297 RNDLESWSQIRVQEINTQTNRQNAEINHKRDEVKRLHSQVSELKSKHAELAARNGLLEKQLEDLN 361

Human   368 QRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLES 432
            .:.|...:...|.|::.:|.:::.:::....|.|.|.|::.|..||.|:..||::|||...  |:
 Worm   362 YQLEDDQRSYEAALNDKDAQVRKLREECQALLVELQMLLDTKQTLDGELKVYRRMLEGNSE--EN 424

Human   433 GMQ------------NMSIHTKTTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTSS 485
            |::            |..:.|:|.....|..||.        .||.     .|..|:.|....|.
 Worm   425 GLRQLVEKVVRTSAINEEVDTETMRVVKGEHSSR--------TSYQ-----RSAKGNVSIKEVSP 476

Human   486 SRAVVVKKIETRD 498
            ....|:.:...||
 Worm   477 EGKFVILENTHRD 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KRT8	NP_001243211.1	Keratin_2_head	<91..115	CDD:465068	1/23 (4%)
		Filament	118..429	CDD:459643	79/353 (22%)
ifa-3	NP_510649.3	solA	<15..>86	CDD:236887	23/110 (21%)
		Filament	71..419	CDD:459643	77/348 (22%)
		LTD	464..570	CDD:460003	7/26 (27%)