DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KRT8 and ifa-3

DIOPT Version :9

Sequence 1:	NP_001243211.1	Gene:	KRT8 / 3856	HGNCID:	6446	Length:	511	Species:	Homo sapiens
Sequence 2:	NP_510649.3	Gene:	ifa-3 / 181699	WormBaseID:	WBGene00002051	Length:	581	Species:	Caenorhabditis elegans

Alignment Length:	533	Identity:	113/533 - (21%)
Similarity:	231/533 - (43%)	Gaps:	113/533 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    23 STPASTMSIRVTQKSYKVSTSGPRAFS--SRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGA 85
            |.||...::..:.::|....||.|...  :.::||...|.:|..                |.|.|
Worm    13 SRPAFNRTVTSSTQNYGTPASGNRVLKIVTETHTSSVASGLSPY----------------GQGAA 61

Human    86 SGMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETK 150
            |                        .|:..|.:||::|..||::.||:|.|||||..||:.||..
Worm    62 S------------------------TIRDDREREKKEITELNDRLASYIGKVRFLAAQNRKLEAD 102

Human   151 WSLLQQQ-KTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYED----- 209
            .::||.: ..:..::..|:|..|......::..|::..:.|.|:|.::..:::.:.|:|:
Worm   103 LNVLQSRFGKSTGSVKIMYEMEITTATNVVKETGKDHEEAEKEIGKIKDQLDELRKKFEEAQKGR 167

Human   210 -------------------EIN-------------KRTEMEN-----EFVLIKKDVDEAYMNKVE 237
                               |||             .|.:.||     |...::.::|:..:.:::
Worm   168 AEDRLKIDELLVTLSNLEAEINLLKRRIALLEEEVARLKKENFRLTSELQRVRSELDQETLLRID 232

Human   238 LESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRS 302
            .::::..:.:||:|:::.:|.|:::||:|.:..:...:.:..::..|:| |.:::|:|:.....:
Worm   233 NQNKVTTILEEIDFMKRGFETELKDLQAQAARDTTSENREYFKNELMNS-IRDIRAEYDRFMAGN 296

Human   303 RAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAE 367
            |.:.||..||:.:|:.:...:...::...:.|:..::..:|.|:::...|..:...||..:.|..
Worm   297 RNDLESWSQIRVQEINTQTNRQNAEINHKRDEVKRLHSQVSELKSKHAELAARNGLLEKQLEDLN 361

Human   368 QRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLES 432
            .:.|...:...|.|::.:|.:::.:::....|.|.|.|::.|..||.|:..||::|||...  |:
Worm   362 YQLEDDQRSYEAALNDKDAQVRKLREECQALLVELQMLLDTKQTLDGELKVYRRMLEGNSE--EN 424

Human   433 GMQ------------NMSIHTKTTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTSS 485
            |::            |..:.|:|.....|..||.        .||.     .|..|:.|....|.
Worm   425 GLRQLVEKVVRTSAINEEVDTETMRVVKGEHSSR--------TSYQ-----RSAKGNVSIKEVSP 476

Human   486 SRAVVVKKIETRD 498
            ....|:.:...||
Worm   477 EGKFVILENTHRD 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KRT8	NP_001243211.1	Keratin_2_head	<91..115	CDD:292825	1/23 (4%)
		Filament	118..429	CDD:278467	79/353 (22%)
		HAUS2	315..>404	CDD:291664	14/88 (16%)
ifa-3	NP_510649.3	Filament	71..419	CDD:278467	77/348 (22%)
		DUF342	<140..209	CDD:302792	9/68 (13%)
		DUF904	181..245	CDD:283624	9/63 (14%)
		LTD	462..570	CDD:279300	7/33 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I2296
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X62
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910