DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tie and Tie1

DIOPT Version :10

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_445997.1 Gene:Tie1 / 89806 RGDID:621642 Length:1137 Species:Rattus norvegicus


Alignment Length:1406 Identity:305/1406 - (21%)
Similarity:465/1406 - (33%) Gaps:535/1406 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 WLLLLLLVALLLAEAIVAAAAATL------SETQ------TNATNGAIRE-----PPVQLQLQQQ 117
            |....||..|.||..:.|:...||      :|.|      .:...||.|.     ||:.|:...:
  Rat     4 WGSPFLLPILFLASHVGASVDLTLLANLRITEPQRFFLTCVSGEAGAGRSSDVWGPPLLLEKDDR 68

  Fly   118 QLQ-------LQLQLNAT--------------------AGDGESRNSAEIF---SPGDVDVVGDK 152
            .::       |.|..|.:                    .|...:|.:..::   ||| ..:..||
  Rat    69 IVRTFPPGQPLHLTRNGSHQVTLRGFSKPSDLVGVFSCVGGAGTRRTRVLYVHNSPG-AHLFPDK 132

  Fly   153 PTTYRPSGANRPSIAPLNSAQDRERKLMNVLAARRTA---------LHRGGFRTRIGTTGRTAIS 208
            .|    ...|:...|.| ||:..:.|..:|:.....:         .|.|.|:.::    :....
  Rat   133 VT----HTVNKGDTAVL-SARVHKEKQTDVIWKNNGSYFHTLDWHEAHDGRFQLQL----QNVQP 188

  Fly   209 PSAAVESTSKAPSDP------RSV------------CIRN------------------CTKNFT- 236
            ||:.:.|.:...:.|      |.:            |:::                  |...|| 
  Rat   189 PSSGIYSATYLEASPLGSAFFRLIVRGCEAGRWGPGCVKDCPGCLHGGVCHDHDGECVCPPGFTG 253

  Fly   237 ---------RRTTASCMRQCANFT-----RMAMP-----SNGNSSVVLKGSASLKAAAPAGDRDT 282
                     .|...||..||....     ...:|     |.|:.   .:||...:|.||      
  Rat   254 TRCEQACREGRFGQSCQEQCPGTAGCRGLTFCLPDPYGCSCGSG---WRGSQCQEACAP------ 309

  Fly   283 NEILFSDESSHGLF-----VVAKEQNGTLNHIADGTKPAVMGKGIPSKTNSMEDDVEEEEDELKP 342
                       |.|     :..:.|||       ||.....|...||..:.:..   |:.|.:..
  Rat   310 -----------GHFGADCRLQCQCQNG-------GTCDRFSGCVCPSGWHGVHC---EKSDRIPQ 353

  Fly   343 YVYFGAKLP------------------PIRPGGLTIKAAEGDDDHPRVLEVSVAQSTTPTITTTS 389
            .:....:|.                  |:| |.:.::..:|                    |...
  Rat   354 ILNVATELEFNLGTMPRINCAAAGNPFPVR-GSMELRKPDG--------------------TMLL 397

  Fly   390 TTPAPVSSTRPTASTRRP--------------LTPVERSRSKYKYHMRERGLVPTAAPPPAAPPA 440
            :|.|.|...|.||....|              .|...:...::|.:::             .||.
  Rat   398 STKAIVEPDRTTAEFEVPRLTLGDSGFWECRVSTSGGQDSRRFKVNVK-------------VPPV 449

  Fly   441 PPVSRTRYVGSGRPTAGLSDSIQDLKQTESEVAKPVVRRVVQKVSPSSSTPLIITVLSAEEETTV 505
             |::..|.:.               ||:...|..|:       ||.....|:....|....:.::
  Rat   450 -PLTAPRLLA---------------KQSRQLVVSPL-------VSFGGDGPISSVRLHYRPQDSM 491

  Fly   506 GQTEALPTDESTTTTSTTTTTEKPSTTTSTSTTTTTP--------VPSTSKRTTTNAPLSTTNTP 562
            ....|:..|.|   .:.|....||.|..:.....:.|        .|||         |.||:.|
  Rat   492 ITWSAIVVDPS---ENVTLMNLKPRTGYNVRVQLSRPGEGGEGAWGPST---------LMTTDCP 544

  Fly   563 TTTTSSTTPSTTTTS------STSTTVIPTTTKANSIIEKDKELIR----ALGPALTREINIDDA 617
            .........|.....      |.|...:|        :..|..|:|    |.|......|:...|
  Rat   545 EPLLQPWVESWNVEGPDRLRVSWSLPSVP--------LSGDGFLLRLWDGARGQERRENISSPQA 601

  Fly   618 NNLIVFCNNTSDCGVTPRTQTQ---------------PS---HTTDS---SPKILRTTVLTSIRS 661
            ...::       .|:||.|..|               ||   |...|   :|:.||...|:....
  Rat   602 RTALL-------TGLTPGTHYQLDVRLYHCTLLGPASPSAHVHLPLSGPPAPRHLRAQALSDSEI 659

  Fly   662 TV---HPRPTSTSTTTSTTTTAPPAVTAPSNEVYIGIVESSSSA--------SPADISSTVIANE 715
            .:   ||.             |||   .|.::..:.|..:..|.        .|.:.|:||    
  Rat   660 RLMWQHPE-------------APP---GPISKYIVEIQVAGGSGDPQWMDVDKPEETSTTV---- 704

  Fly   716 RDLNMEMRRM--------------NLV---------------------------TLVLVAVGVIP 739
            |.||...|.:              |.|                           .|||..||.:.
  Rat   705 RGLNASTRYLFRVRASVQGLGDWSNTVEETTLGNGLQSASPVQESRVAEDGLDQQLVLAVVGSVS 769

  Fly   740 ------LAAII-LYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHH 797
                  |||:: |..:|...:.||    ..|                  .||....|:.:     
  Rat   770 ATCLTILAALLALVCIRRSCLHRR----HTF------------------TYQSGSGEETI----- 807

  Fly   798 QHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGE 862
              :|..............|..|:|                        :...|..:|..:.|:||
  Rat   808 --LQFSSGTLTLTRRPKPQPEPLS------------------------YPVLEWEDITFEDLIGE 846

  Fly   863 GNFGQVWKA--EADDLSGHFGATRIVAVKTIRACSAQVSLKD---EANIMRKLGSHQNVVTLLGA 922
            ||||||.:|  :.|.|..:      .|:|.::..:::...:|   |..::.|||.|.|::.||||
  Rat   847 GNFGQVIRAMIKKDGLKMN------AAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGA 905

  Fly   923 CVESEPHMLI-MEYAMRGRLLSLLRAARSATNIL---PASVPGGRSLAPLSPRTLAGFALDIACG 983
            | |:..::.| :|||..|.||..||.:|    :|   ||......:.:.||.|.|..||.|.|.|
  Rat   906 C-ENRGYLYIAIEYAPYGNLLDFLRKSR----VLETDPAFAREHGTASTLSSRQLLRFASDAANG 965

  Fly   984 MEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKF 1048
            |:|::.::.:||||||||||:..|...||.|||:|        |.|:.                 
  Rat   966 MQYLSEKQFIHRDLAARNVLVGENLASKIADFGLS--------RGEEV----------------- 1005

  Fly  1049 DFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTT 1113
                 |:                         ||      |:|:   ||:||||.|||.|.::||
  Rat  1006 -----YV-------------------------KK------TMGR---LPVRWMAIESLNYSVYTT 1031

  Fly  1114 ETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMR 1178
            ::|:|:||::||||.:||.|||..:|..|:..::|||.|.:.|:....|.|.||.:||...|:.|
  Rat  1032 KSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYER 1096

  Fly  1179 PSFAQSRLEITRSLHKWVDDDSAASDYMDVSGFSEDLEHGV 1219
            |.|||..|::.|.|       .|...|:::|.|......|:
  Rat  1097 PPFAQIALQLGRML-------EARKAYVNMSLFENFTYAGI 1130

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 118/337 (35%)
Tie1NP_445997.1 ig 130..211 CDD:395002 17/89 (19%)
Furin-like 217..339 CDD:395614 26/148 (18%)
EGF_Lam 228..266 CDD:238012 4/37 (11%)
Ig 351..442 CDD:472250 14/111 (13%)
Ig strand B 369..373 CDD:409556 0/3 (0%)
Ig strand C 385..389 CDD:409556 0/3 (0%)
Ig strand E 410..414 CDD:409556 1/3 (33%)
Ig strand F 424..429 CDD:409556 0/4 (0%)
Ig strand G 437..440 CDD:409556 0/2 (0%)
fn3 450..530 CDD:394996 18/104 (17%)
fn3 549..631 CDD:394996 16/96 (17%)
FN3 643..735 CDD:238020 22/111 (20%)
PTKc_Tie1 835..1131 CDD:270671 128/378 (34%)

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