DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and Tie1

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_445997.1	Gene:	Tie1 / 89806	RGDID:	621642	Length:	1137	Species:	Rattus norvegicus

Alignment Length:	1406	Identity:	305/1406 - (21%)
Similarity:	465/1406 - (33%)	Gaps:	535/1406 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 WLLLLLLVALLLAEAIVAAAAATL------SETQ------TNATNGAIRE-----PPVQLQLQQQ 117
            |....||..|.||..:.|:...||      :|.|      .:...||.|.     ||:.|:...:
  Rat     4 WGSPFLLPILFLASHVGASVDLTLLANLRITEPQRFFLTCVSGEAGAGRSSDVWGPPLLLEKDDR 68

  Fly   118 QLQ-------LQLQLNAT--------------------AGDGESRNSAEIF---SPGDVDVVGDK 152
            .::       |.|..|.:                    .|...:|.:..::   ||| ..:..||
  Rat    69 IVRTFPPGQPLHLTRNGSHQVTLRGFSKPSDLVGVFSCVGGAGTRRTRVLYVHNSPG-AHLFPDK 132

  Fly   153 PTTYRPSGANRPSIAPLNSAQDRERKLMNVLAARRTA---------LHRGGFRTRIGTTGRTAIS 208
            .|    ...|:...|.| ||:..:.|..:|:.....:         .|.|.|:.::    :....
  Rat   133 VT----HTVNKGDTAVL-SARVHKEKQTDVIWKNNGSYFHTLDWHEAHDGRFQLQL----QNVQP 188

  Fly   209 PSAAVESTSKAPSDP------RSV------------CIRN------------------CTKNFT- 236
            ||:.:.|.:...:.|      |.:            |:::                  |...||
  Rat   189 PSSGIYSATYLEASPLGSAFFRLIVRGCEAGRWGPGCVKDCPGCLHGGVCHDHDGECVCPPGFTG 253

  Fly   237 ---------RRTTASCMRQCANFT-----RMAMP-----SNGNSSVVLKGSASLKAAAPAGDRDT 282
                     .|...||..||....     ...:|     |.|:.   .:||...:|.||
  Rat   254 TRCEQACREGRFGQSCQEQCPGTAGCRGLTFCLPDPYGCSCGSG---WRGSQCQEACAP------ 309

  Fly   283 NEILFSDESSHGLF-----VVAKEQNGTLNHIADGTKPAVMGKGIPSKTNSMEDDVEEEEDELKP 342
                       |.|     :..:.|||       ||.....|...||..:.:..   |:.|.:..
  Rat   310 -----------GHFGADCRLQCQCQNG-------GTCDRFSGCVCPSGWHGVHC---EKSDRIPQ 353

  Fly   343 YVYFGAKLP------------------PIRPGGLTIKAAEGDDDHPRVLEVSVAQSTTPTITTTS 389
            .:....:|.                  |:| |.:.::..:|                    |...
  Rat   354 ILNVATELEFNLGTMPRINCAAAGNPFPVR-GSMELRKPDG--------------------TMLL 397

  Fly   390 TTPAPVSSTRPTASTRRP--------------LTPVERSRSKYKYHMRERGLVPTAAPPPAAPPA 440
            :|.|.|...|.||....|              .|...:...::|.:::             .||.
  Rat   398 STKAIVEPDRTTAEFEVPRLTLGDSGFWECRVSTSGGQDSRRFKVNVK-------------VPPV 449

  Fly   441 PPVSRTRYVGSGRPTAGLSDSIQDLKQTESEVAKPVVRRVVQKVSPSSSTPLIITVLSAEEETTV 505
             |::..|.:.               ||:...|..|:       ||.....|:....|....:.::
  Rat   450 -PLTAPRLLA---------------KQSRQLVVSPL-------VSFGGDGPISSVRLHYRPQDSM 491

  Fly   506 GQTEALPTDESTTTTSTTTTTEKPSTTTSTSTTTTTP--------VPSTSKRTTTNAPLSTTNTP 562
            ....|:..|.|   .:.|....||.|..:.....:.|        .|||         |.||:.|
  Rat   492 ITWSAIVVDPS---ENVTLMNLKPRTGYNVRVQLSRPGEGGEGAWGPST---------LMTTDCP 544

  Fly   563 TTTTSSTTPSTTTTS------STSTTVIPTTTKANSIIEKDKELIR----ALGPALTREINIDDA 617
            .........|.....      |.|...:|        :..|..|:|    |.|......|:...|
  Rat   545 EPLLQPWVESWNVEGPDRLRVSWSLPSVP--------LSGDGFLLRLWDGARGQERRENISSPQA 601

  Fly   618 NNLIVFCNNTSDCGVTPRTQTQ---------------PS---HTTDS---SPKILRTTVLTSIRS 661
            ...::       .|:||.|..|               ||   |...|   :|:.||...|:....
  Rat   602 RTALL-------TGLTPGTHYQLDVRLYHCTLLGPASPSAHVHLPLSGPPAPRHLRAQALSDSEI 659

  Fly   662 TV---HPRPTSTSTTTSTTTTAPPAVTAPSNEVYIGIVESSSSA--------SPADISSTVIANE 715
            .:   ||.             |||   .|.::..:.|..:..|.        .|.:.|:||
  Rat   660 RLMWQHPE-------------APP---GPISKYIVEIQVAGGSGDPQWMDVDKPEETSTTV---- 704

  Fly   716 RDLNMEMRRM--------------NLV---------------------------TLVLVAVGVIP 739
            |.||...|.:              |.|                           .|||..||.:.
  Rat   705 RGLNASTRYLFRVRASVQGLGDWSNTVEETTLGNGLQSASPVQESRVAEDGLDQQLVLAVVGSVS 769

  Fly   740 ------LAAII-LYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHH 797
                  |||:: |..:|...:.||    ..|                  .||....|:.:
  Rat   770 ATCLTILAALLALVCIRRSCLHRR----HTF------------------TYQSGSGEETI----- 807

  Fly   798 QHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGE 862
              :|..............|..|:|                        :...|..:|..:.|:||
  Rat   808 --LQFSSGTLTLTRRPKPQPEPLS------------------------YPVLEWEDITFEDLIGE 846

  Fly   863 GNFGQVWKA--EADDLSGHFGATRIVAVKTIRACSAQVSLKD---EANIMRKLGSHQNVVTLLGA 922
            ||||||.:|  :.|.|..:      .|:|.::..:::...:|   |..::.|||.|.|::.||||
  Rat   847 GNFGQVIRAMIKKDGLKMN------AAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGA 905

  Fly   923 CVESEPHMLI-MEYAMRGRLLSLLRAARSATNIL---PASVPGGRSLAPLSPRTLAGFALDIACG 983
            | |:..::.| :|||..|.||..||.:|    :|   ||......:.:.||.|.|..||.|.|.|
  Rat   906 C-ENRGYLYIAIEYAPYGNLLDFLRKSR----VLETDPAFAREHGTASTLSSRQLLRFASDAANG 965

  Fly   984 MEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKF 1048
            |:|::.::.:||||||||||:..|...||.|||:|        |.|:.
  Rat   966 MQYLSEKQFIHRDLAARNVLVGENLASKIADFGLS--------RGEEV----------------- 1005

  Fly  1049 DFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTT 1113
                 |:                         ||      |:|:   ||:||||.|||.|.::||
  Rat  1006 -----YV-------------------------KK------TMGR---LPVRWMAIESLNYSVYTT 1031

  Fly  1114 ETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMR 1178
            ::|:|:||::||||.:||.|||..:|..|:..::|||.|.:.|:....|.|.||.:||...|:.|
  Rat  1032 KSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYER 1096

  Fly  1179 PSFAQSRLEITRSLHKWVDDDSAASDYMDVSGFSEDLEHGV 1219
            |.|||..|::.|.|       .|...|:::|.|......|:
  Rat  1097 PPFAQIALQLGRML-------EARKAYVNMSLFENFTYAGI 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	118/337 (35%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	118/335 (35%)
Tie1	NP_445997.1	ig	130..211	CDD:278476	17/89 (19%)
		EGF_Lam	228..266	CDD:238012	4/37 (11%)
		EGF_CA	315..346	CDD:238011	8/40 (20%)
		ig	357..442	CDD:278476	14/105 (13%)
		IG_like	370..444	CDD:214653	14/94 (15%)
		fn3	450..530	CDD:278470	18/104 (17%)
		fn3	549..631	CDD:278470	16/96 (17%)
		FN3	643..735	CDD:238020	22/111 (20%)
		PTKc_Tie1	835..1131	CDD:270671	128/378 (34%)
		TyrKc	838..1106	CDD:197581	121/342 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000