DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and Tek

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001099207.1	Gene:	Tek / 89804	RGDID:	620980	Length:	1120	Species:	Rattus norvegicus

Alignment Length:	888	Identity:	202/888 - (22%)
Similarity:	332/888 - (37%)	Gaps:	282/888 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 GRPTAGLSDSIQDLK---QTESEVAKPVVRRVVQKVSPSSSTPLIITVLSAEEETTVGQTEALPT 513
            |||.  ::..|:||.   :..|....|:.:        :|..|                   |||
  Rat   344 GRPR--MTPQIEDLPDHIEVNSGKFNPICK--------ASGWP-------------------LPT 379

  Fly   514 DESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTT-- 576
            .|..|......|..:|:....|...:..              :.|.|......|.....:..|
  Rat   380 SEEMTLVKPDGTVLQPNDFNHTDHFSVA--------------IFTVNRILPPDSGVWVCSVNTVA 430

  Fly   577 ------SSTSTTVIPTTTKANSIIEK---------DKELIRALGPALTREINIDDAN-------- 618
                  .:.|..|:|....|.::|:.         ..|.....||..::::.....|
  Rat   431 GMVEKPFNISVKVLPEPLHAPNVIDTGHNFAIINISSEPYFGDGPIKSKKLFYKPVNQAWKYIQV 495

  Fly   619 -NLIVFCNNTSDCGVTPRTQ-------TQPSHTTDSSPKILRTTVLTSIRSTVHPRPTSTS---- 671
             |.||..|.     :.|||.       .:|....:..|..:|.....||..   |.|...|
  Rat   496 MNEIVTLNY-----LEPRTDYELCVQLVRPGEGGEGHPGPVRRFTTASIGL---PPPRGLSLLPK 552

  Fly   672 TTTSTTTTAPPAVTAPSNEVYIGIVESSSSAS--------PADISSTVIAN-------------- 714
            :.|:...|..|..|:..:|.|:.:...|....        |.:::|.::.|
  Rat   553 SQTALNLTWQPIFTSSEDEFYVEVERWSQQTRSDQQNIKVPGNLTSVLLNNLLPREQYSVRARVN 617

  Fly   715 ---ERDLNMEMRRMNL------------VTLVLVAVGVIPLAAIILYLVRNFVIRRRAK---QSE 761
               :.:.:.|:|...|            :|.:.....::....:..|.:.:.:||.:.:   :.:
  Rat   618 TKAQGEWSEELRAWTLSDILPPQPENIKITNITDYTALVSWTIVDGYSISSIIIRYKVQGKNEDQ 682

  Fly   762 VFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMP------- 819
            ..||.|.:        ...::||:...|.|..:......:::....|....|..:.:|
  Rat   683 HIDVKIKN--------ATITQYQLKGLEPETTYHVDIFAENNIGSSNPAFSQEIRTLPAPKDLGG 739

  Fly   820 -------------------------------------MSQASQ--RD-----------ANHNRYG 834
                                                 |:||.|  |:           |.:.:..
  Rat   740 GKMLLIAILGSAGMTCITVLLAFLIMLQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKAK 804

  Fly   835 NNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKA--EADDLSGHFGATRIVAVKTIRACSAQ 897
            ||.|.|.    :...:.::|:.:.::||||||||.||  :.|      |.....|:|.::..:::
  Rat   805 NNPDPTI----YPVLDWNDIKFQDVIGEGNFGQVLKARIKKD------GLRMDAAIKRMKEYASK 859

  Fly   898 VSLKD---EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNIL---P 956
            ...:|   |..::.|||.|.|::.|||||.......|.:|||..|.||..||.:|    :|   |
  Rat   860 DDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSR----VLETDP 920

  Fly   957 ASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDL 1021
            |......:.:.||.:.|..||.|:|.||:|::.::.:||||||||:|:..|.:.||.|||:|
  Rat   921 AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLS--- 982

  Fly  1022 DAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHG 1086
                  :.||.                     |:                         ||
  Rat   983 ------RGQEV---------------------YV-------------------------KK---- 991

  Fly  1087 HDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGL 1151
              |:|:   ||:||||.|||.|.::||.:|:|::|::||||.:||.|||..:|..|:..::|||.
  Rat   992 --TMGR---LPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGY 1051

  Fly  1152 RPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHK 1194
            |.:.|.....|.|:||.:||.::|:.||||||..:.:.|.|.:
  Rat  1052 RLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEE 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	115/336 (34%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	116/334 (35%)
Tek	NP_001099207.1	Ig_Tie2_1	24..118	CDD:287411
		EGF_Lam	230..275	CDD:238012
		fn3	445..518	CDD:278470	14/77 (18%)
		fn3	542..625	CDD:278470	13/82 (16%)
		FN3	638..730	CDD:238020	13/99 (13%)
		PTKc_Tie2	812..1114	CDD:133219	119/357 (33%)
		STYKc	820..1088	CDD:214568	117/341 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000