DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tie and Fgfr3

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	XP_006251452.1	Gene:	Fgfr3 / 84489	RGDID:	620714	Length:	804	Species:	Rattus norvegicus

Alignment Length:	399	Identity:	120/399 - (30%)
Similarity:	183/399 - (45%)	Gaps:	102/399 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   848 DFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRI-VAVKTIRACSAQVSLKD---EANIMR 908
            :..|:.:.|...||||.||||..|||..:.....|..: ||||.::..:....|.|   |..:|:
  Rat   464 ELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMK 528

  Fly   909 KLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLA------- 966
            .:|.|:|::.|||||.:..|..:::|||.:|.|...|||.|          |.|...:
  Rat   529 MIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARR----------PPGMDYSFDACRLP 583

  Fly   967 --PLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKE 1029
              .|:.:.|...|..:|.||||:|.::.:||||||||||:..:.:.||.|||::.|:
  Rat   584 EEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDV-------- 640

  Fly  1030 QEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRH 1094
                       ||...:                                  ||:.:|.
  Rat   641 -----------HNLDYY----------------------------------KKTTNGR------- 653

  Fly  1095 ALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKES 1159
             ||::|||||:|...::|.::|:|:||::||||.|||.:||..:...|:.:.:.:|.|.|.|...
  Rat   654 -LPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANC 717

  Fly  1160 RHEFYNLMSRCWHKEPHMRPSFAQ-----SRLEITRSLHKWVD-------------DDSAASDYM 1206
            .|:.|.:|..|||..|..||:|.|     .|:....|..:::|             |..::|...
  Rat   718 THDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTSTDEYLDLSVPFEQYSPGGQDTPSSSSSG 782

  Fly  1207 DVSGFSEDL 1215
            |.|.|:.||
  Rat   783 DDSVFTHDL 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	108/341 (32%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	109/344 (32%)
Fgfr3	XP_006251452.1	IGc2	51..108	CDD:197706
		IG	52..123	CDD:214652
		Ig2_FGFR	155..239	CDD:143265
		IG_like	254..349	CDD:214653
		Ig3_FGFR	262..350	CDD:143175
		PTKc_FGFR3	457..790	CDD:173652	118/396 (30%)
		Pkinase_Tyr	470..746	CDD:285015	109/346 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900