DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and kdrl

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_571547.1	Gene:	kdrl / 796537	ZFINID:	ZDB-GENE-000705-1	Length:	1301	Species:	Danio rerio

Alignment Length:	1130	Identity:	237/1130 - (20%)
Similarity:	373/1130 - (33%)	Gaps:	429/1130 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 IPSKTNSMEDDVEEEED---------ELKPY-------------------VYFGAKLPPIRPGGL 358
            :.::.|.|.|||:....         .||||                   ||...:|.      :
Zfish   161 LETQMNPMADDVKRGVQWDPKKGFTVPLKPYDSYHLITCLTRVDNAEFSSVYLLKRLT------M 219

  Fly   359 TIKAAEGDDDHPRVL---------------------------------------EVSVAQ----- 379
            .||....:.:.||||                                       .|.:||
Zfish   220 EIKNLAIEPERPRVLVGDTLILNCSAETTYNGRIHFEWEFHKERINRPHHFSTTPVQLAQIMVMS 284

  Fly   380 --STTPTITT----TSTTPAPVSSTRPTASTR-----RPLTPVERSRSKYKYHMRERGLVPTAAP 433
              ...|.:|.    |.|....:...:...||:     .|...|..::.|:...:..|.:  ...|
Zfish   285 KALIVPNVTMEDKGTYTCTGSIEFKKLQMSTKVIVYEHPFLNVTHNKRKFTSTVEGRRV--QFEP 347

  Fly   434 PPAAPPAPPVSRTRYVGSG---------RPTAGLSDSIQDLKQTE--------SEVAKPVVRRVV 481
            ...|.|||  .|..:...|         ..|||.:.:|:.::|.:        |...:.:.|.:.
Zfish   348 RVNAVPAP--DRVLWYKDGVAISENSTCYETAGYNLTIKQVRQKDAGIFTIALSNQERGLYRNIS 410

  Fly   482 QKVSPSSSTPLIITVLSAEEETTVGQTEALPTDESTTTTSTTTTTEKPSTT-------TSTSTTT 539
            .|:.......:.      ||:......:....|:....|.|......|:.|       .|.:.|.
Zfish   411 YKLEVRVKPKIF------EEDVAPAGPQTFRYDQRHKLTCTAFGIPMPNITWFWQPCDPSANLTE 469

  Fly   540 ----TTPVPSTSKRTTTNAPLSTTNTPT--TTTSSTTPSTTTTSSTSTTVIPTTTKANSI----- 593
                |.|:|..:.......|:...|:..  ..:.:.|.||....:.:.:.:.:.|..|.:
Zfish   470 CKLYTDPLPIENVDDFPQNPIKDVNSKVGLLKSKNRTISTLVVKTANVSGVYSCTARNELGNRTM 534

  Fly   594 -------------------------------------------------IEKDKELIR------A 603
                                                             :.||:..:|      :
Zfish   535 RIPFYVDDHPQPFEIEPSTAVAGDDITLTCRGTRYLYDRLTWYDPLGYKVPKDETTLRIEPYTIS 599

  Fly   604 LG---PALTRE---------INIDDANNLIVFCNNTSDCGVTPR-----TQTQPSHTTDSSPKIL 651
            |.   |.::|.         :||:  .|.:|  |.||...:..|     .|...:...:||
Zfish   600 LSIKLPNVSRNHTLGYECQALNIN--TNKVV--NVTSALTIDERQGPWLMQNLTNQDVNSS---- 656

  Fly   652 RTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEVYI---------GIVE--SSSSASPA 705
            .|..|..:...| |.|..|.....|..|..|.:|...:...|         ||.|  :|:....|
Zfish   657 STLTLACLAYGV-PAPFITWYKDKTPVTEGPGITLKDDGTLIIERVKKDDEGIYECRASNDGGEA 720

  Fly   706 DISS--TVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCIT 768
            ..|:  ||:..:...|:|:       ::||:.|.   ||..|:::....||:..|
Zfish   721 KTSAVITVVGEDGKPNIEV-------IILVSTGA---AATFLWIMLILFIRKLRK---------- 765

  Fly   769 DQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQR---DANH 830
               |.|...|......:.|.|.                           ||:.:...|   |:|.
Zfish   766 ---PSSADLKTGYLSIIMDPEQ---------------------------MPLDEQCDRLPYDSNK 800

  Fly   831 NRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACS 895
                            .:|.:..:||...||.|.||:|.:|.|      ||..:|...||:....
Zfish   801 ----------------WEFPQDRLRLGKTLGHGAFGKVVEASA------FGIDKISTCKTVAVKM 843

  Fly   896 AQV--------SLKDEANIMRKLGSHQNVVTLLGACVE-SEPHMLIMEYAMRGRLLSLLRAARSA 951
            .:|        :|..|..|:..:|.|.|||.|||||.: ..|.|:|:|:...|.|.:.||:.| .
Zfish   844 LKVGATNNEWRALMSELKILIHIGHHLNVVNLLGACTKRGGPLMIIVEFCKYGNLSNYLRSKR-G 907

  Fly   952 TNILPASVPG-------GRSLAPLSPRTL-----------AGFALD------------------- 979
            ..::..|..|       |..|:.|..|.|           :||..|
Zfish   908 DFVVYKSQDGKAVRSSSGCDLSELIKRRLESVASTGSSASSGFIEDKSYCDSEEEEEEQEDLYKK 972

  Fly   980 -------------IACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDL--DAERMRKE 1029
                         :|.|||::|.|:.:||||||||:||..|.:.||||||::.|:  |.:.:||
Zfish   973 VLTLEDLICYSFQVAKGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARDVYKDPDYVRK- 1036

  Fly  1030 QEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRH 1094
                                                             |:.:
Zfish  1037 -------------------------------------------------GDAR------------ 1040

  Fly  1095 ALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQL-TGREVIRRVPQGLRPDLPKE 1158
             ||::|||||::...::||::|:|:||:::|||.:||::||..| ...|...|:.:|.|...|:.
Zfish  1041 -LPLKWMAPEAIFDKIYTTQSDVWSFGVLMWEIFSLGASPYPGLHIDEEFCCRLKEGTRMKAPEY 1104

  Fly  1159 SRHEFYNLMSRCWHKEPHMRPSFAQ 1183
            |..|.|..|..|||.||..||:|.:
Zfish  1105 SSSEIYQTMLDCWHGEPSQRPTFTE 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	114/390 (29%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	112/386 (29%)
kdrl	NP_571547.1	IG_like	47..120	CDD:214653
		IG_like	228..319	CDD:214653	13/90 (14%)
		Ig	236..321	CDD:299845	9/84 (11%)
		IG_like	338..415	CDD:214653	16/80 (20%)
		Ig	343..415	CDD:299845	15/75 (20%)
		Ig	441..533	CDD:143165	16/91 (18%)
		IG_like	553..631	CDD:214653	11/81 (14%)
		I-set	646..728	CDD:254352	20/86 (23%)
		Ig	659..725	CDD:143165	16/66 (24%)
		PKc_like	800..1141	CDD:304357	115/416 (28%)
		Pkinase_Tyr	808..1134	CDD:285015	114/392 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1158..1178
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1265..1291
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000