DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tie and Frk

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_077344.1	Gene:	Frk / 79209	RGDID:	621423	Length:	506	Species:	Rattus norvegicus

Alignment Length:	367	Identity:	107/367 - (29%)
Similarity:	160/367 - (43%)	Gaps:	94/367 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   848 DFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVS-LKDEANIMRKLG 911
            :.:|::|:|...||.|.||:||:       |.:..|..|||||::..|...: ...||.||:.|
  Rat   229 EIDRNSIQLLKRLGSGQFGEVWE-------GLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSL- 285

  Fly   912 SHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGF 976
            .|..::.|...|...:|..:|.|....|.|...|:             ..|.|...|:.:  ...
  Rat   286 RHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQ-------------NDGGSKIRLTQQ--VDM 335

  Fly   977 ALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRH 1041
            |..:|.||.|:..:..:||||||||||:..:.:.|:.|||:
  Rat   336 AAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGL------------------------ 376

  Fly  1042 NAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESL 1106
             |..||.|....|..:|                     |.|             ||::|.|||::
  Rat   377 -ARVFKVDNEDIYESKH---------------------EIK-------------LPVKWTAPEAI 406

  Fly  1107 QYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCW 1171
            :.:.|:.::|:|:|||:|:||.|.|..|||.:||.:||..:.|..|...|.....:||::|..||
  Rat   407 RTNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIHMLGQNYRLPQPSNCPEQFYSIMMECW 471

  Fly  1172 HKEPHMRPSFAQSRLEITRSLHKWVDDD--SAASDYMDVSGF 1211
            :.||..||:|        .:|| |..:|  ...|.|.|.:.|
  Rat   472 NVEPKQRPTF--------ETLH-WKLEDYFEPDSSYSDTNNF 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	98/329 (30%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	96/327 (29%)
Frk	NP_077344.1	SH3_Src_like	48..105	CDD:212779
		SH2_Src_Frk	113..208	CDD:199831
		PTKc_Frk_like	226..495	CDD:270653	103/356 (29%)
		Pkinase_Tyr	235..488	CDD:285015	101/343 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010