DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tie and Fgfr1

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_077060.1	Gene:	Fgfr1 / 79114	RGDID:	620713	Length:	822	Species:	Rattus norvegicus

Alignment Length:	895	Identity:	200/895 - (22%)
Similarity:	332/895 - (37%)	Gaps:	259/895 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   430 TAAPPP-----AAPPAPPVS--------------RTRYVGSGRPTAGLSDSIQDLKQTESEVAKP 475
            ||.|.|     |.|...||.              |.|.....:....|.|.:|..:...:.:...
  Rat    20 TARPAPTLPEQAQPWGVPVEVESLLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGE 84

  Fly   476 VVRRVVQKVSPSSSTPLIITVLSAEEETT---VGQTEALPTDESTTTTSTTTTTEKPSTTTSTST 537
            .| .|...:...|.....:|...:..:||   |..::|||:.|.......:::.||.:..|..:.
  Rat    85 EV-EVRDSIPADSGLYACVTNSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNR 148

  Fly   538 TTTTPV---PSTSKRTTTNAPLSTTNTPTTTTSSTTPSTT------------------------T 575
            ....|.   |...::.....|.:.| ......||.|||.|                        |
  Rat   149 RPVAPYWTSPEKMEKKLHAVPAAKT-VKFKCPSSGTPSPTLRWLKNGKEFKPDHRIGGYKVRYAT 212

  Fly   576 TSSTSTTVIPTTTKAN------------------SIIEKD--KELIRALGPALTREINIDDANNL 620
            .|....:|:| :.|.|                  .::|:.  :.:::|..|| .:.:.:  .:|:
  Rat   213 WSIIMDSVVP-SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPA-NKTVAL--GSNV 273

  Fly   621 IVFCNNTSDCGVTPRTQTQ-PSHT--------TDSSP--KILRTTVLTSI---RSTVHPRPTSTS 671
            ...|...||    |:...| ..|.        .|:.|  :||:|..:.:.   ...:|.|..|..
  Rat   274 EFMCKVYSD----PQPHIQWLKHIEVNGSKIGPDNLPYDQILKTAGVNTTDKEMEVLHLRNVSFE 334

  Fly   672 TTTSTTTTAPPAVTAPSNEVYIGIVESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVG 736
            .....|..|..::....:..::.::|:                     :|.|         .||.
  Rat   335 DAGEYTCLAGNSIGLSHHSAWLTVLEA---------------------LEER---------PAVM 369

  Fly   737 VIPL-AAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHM 800
            ..|| ..||:|....|:|.           |:.....|..:|....|...
  Rat   370 TSPLYLEIIIYCTGAFLIS-----------CMVGSVIIYKMKSGTKKSDF--------------- 408

  Fly   801 QHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGN-----------NDDKTSLASEFHDFE---- 850
                 |.....|:..:::|:.:.....|:.:...|           :...|.:.:...::|
  Rat   409 -----HSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPED 468

  Fly   851 ------RSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRI--VAVKTIRACSAQVSLKD---EA 904
                  |..:.|...||||.||||..|||..|... ...|:  ||||.:::.:.:..|.|   |.
  Rat   469 PRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKD-KPNRVTKVAVKMLKSDATEKDLSDLISEM 532

  Fly   905 NIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASV-----PGGRS 964
            .:|:.:|.|:|::.|||||.:..|..:|:|||.:|.|...|:|.|      |..:     |....
  Rat   533 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR------PPGLEYCYNPSHNP 591

  Fly   965 LAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKE 1029
            ...||.:.|...|..:|.||||:|.::.:||||||||||:..:.:.||.|||::.|:
  Rat   592 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-------- 648

  Fly  1030 QEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRH 1094
                       |:...:                                  ||:.:|.
  Rat   649 -----------HHIDYY----------------------------------KKTTNGR------- 661

  Fly  1095 ALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKES 1159
             ||::|||||:|...::|.::|:|:||::||||.|||.:|...:...|:.:.:.:|.|.|.|...
  Rat   662 -LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPNPGVPVEELFKLLKEGHRMDKPSNC 725

  Fly  1160 RHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVS 1209
            .:|.|.:|..||:..|..||:|.|...::.|.:..     ::..:|:|:|
  Rat   726 TNELYMMMRDCWNAVPSQRPTFKQLVEDLDRIVAL-----TSNQEYLDLS 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	107/338 (32%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	107/336 (32%)
Fgfr1	NP_077060.1	Ig1_FGFR	40..118	CDD:143174	12/78 (15%)
		IG_like	41..118	CDD:214653	12/77 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..162		9/41 (22%)
		I-set	160..247	CDD:254352	14/88 (16%)
		Heparin-binding	160..177		2/17 (12%)
		Ig2_FGFR	163..247	CDD:143265	14/85 (16%)
		IG_like	262..358	CDD:214653	19/102 (19%)
		Ig3_FGFR	270..359	CDD:143175	17/92 (18%)
		PTKc_FGFR1	464..765	CDD:270678	111/373 (30%)
		Pkinase_Tyr	478..754	CDD:285015	108/343 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	770..822		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900