Protein Alignment Tie and YES1

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_005424.1
• Gene: YES1 / 7525
• HGNCID: 12841
• Length: 543
• Species: Homo sapiens
• Alignment Length: 693
• Identity: 163/693 - (23%)
• Similarity: 248/693 - (35%)
• Gaps: 216/693 - (31%)

  Fly   525 TTEKPSTTTS---TSTTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPT 586
            |.|..||:.|   ...||.:|.||:|.:.|.....|.:.||...:|..||....:||.|  |:|:
Human    21 TPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFS--VVPS 83

  Fly   587 TTKANSIIEKDKELIRALGPALTREINIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTDSSPKIL 651
            :..|            .|...:|..:.:.|..     ...|.|.......:.|..:.|:......
Human    84 SYPA------------GLTGGVTIFVALYDYE-----ARTTEDLSFKKGERFQIINNTEGDWWEA 131

  Fly   652 RTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEV-----YIGIVESSSSASPADISSTV 711
            |                  |..|......|....||::.:     |.|      .....|....:
Human   132 R------------------SIATGKNGYIPSNYVAPADSIQAEEWYFG------KMGRKDAERLL 172

  Fly   712 I--ANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPIS 774
            :  .|:|.:                                |::|........:.:.|.|...|.
Human   173 LNPGNQRGI--------------------------------FLVRESETTKGAYSLSIRDWDEIR 205

  Fly   775 -------PVKKVD-------SKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQ 825
                   .::|:|       ::.|.|..:..|        :|:..|.:...|:.....|..:...
Human   206 GDNVKHYKIRKLDNGGYYITTRAQFDTLQKLV--------KHYTEHADGLCHKLTTVCPTVKPQT 262

  Fly   826 RDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKT 890
            :              .||.:..:..|.::||:..||:|.||:||       .|.:..|..||:||
Human   263 Q--------------GLAKDAWEIPRESLRLEVKLGQGCFGEVW-------MGTWNGTTKVAIKT 306

  Fly   891 IR-ACSAQVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNI 954
            :: ......:...||.||:|| .|..:|.|. |.|..||..::.|:..:|.||..|:........
Human   307 LKPGTMMPEAFLQEAQIMKKL-RHDKLVPLY-AVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLK 369

  Fly   955 LPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSI 1019
            ||               .|...|..||.||.||.....:||||.|.|:|:..|.:|||.|||::
Human   370 LP---------------QLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLA- 418

  Fly  1020 DLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSH 1084
                 |:.::.|..|..              |:::
Human   419 -----RLIEDNEYTARQ--------------GAKF------------------------------ 434

  Fly  1085 HGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQ 1149
                        ||:|.|||:..|..||.::|:|:|||:..|:.|.|..||..:..|||:.:|.:
Human   435 ------------PIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVER 487

  Fly  1150 GLRPDLPK---ESRHEFYNLMSRCWHKEPHMRPSF--AQSRLE 1187
            |.|...|:   ||.||..||   ||.|:|..||:|  .||.||
Human   488 GYRMPCPQGCPESLHELMNL---CWKKDPDERPTFEYIQSFLE 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	100/334 (30%)
		PTKc	860..1187	CDD:270623	100/332 (30%)
YES1	NP_005424.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		9/23 (39%)
		SH3_Yes	94..151	CDD:212940	12/79 (15%)
		SH2_Src_family	154..253	CDD:199827	18/144 (13%)
		PTKc_Yes	264..542	CDD:270654	107/353 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010