Protein Alignment Tie and SRC

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: XP_016883513.1
• Gene: SRC / 6714
• HGNCID: 11283
• Length: 542
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 146/611 - (23%)
• Similarity: 226/611 - (36%)
• Gaps: 201/611 - (32%)

  Fly   626 NTSDCGVTP---------------------RTQTQPSHTTDSSPKILRTTVLTSIRS----TVHP 665
            |:||...:|                     ||:|..|.......:|:..|....:|.    ..|
Human    68 NSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTRKVDVREGDWWLAH- 131

  Fly   666 RPTSTSTTTSTTTTAPPAVTAPSNEV-----YIGIVESSSSASPADISSTVIANER-DLNMEMRR 724
                 |.:|..|...|....|||:.:     |.|.:....|             || .||.|..|
Human   132 -----SLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRES-------------ERLLLNAENPR 178

  Fly   725 MNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPIS-------PVKKVD-- 780
                                    ..|::|........:.:.::|.....       .::|:|
Human   179 ------------------------GTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSG 219

  Fly   781 -----SKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKT 840
                 |:.|.:..:        |.:.::..|.:...|:.....|.|:...:
Human   220 GFYITSRTQFNSLQ--------QLVAYYSKHADGLCHRLTTVCPTSKPQTQ-------------- 262

  Fly   841 SLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIR--ACSAQVSLKDE 903
            .||.:..:..|.::||:..||:|.||:||       .|.:..|..||:||::  ..|.:..|: |
Human   263 GLAKDAWEIPRESLRLEVKLGQGCFGEVW-------MGTWNGTTRVAIKTLKPGTMSPEAFLQ-E 319

  Fly   904 ANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPL 968
            |.:|:|| .|:.:|.|. |.|..||..::.||..:|.||..|:........||
Human   320 AQVMKKL-RHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP------------ 370

  Fly   969 SPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKN 1033
               .|...|..||.||.|:.....|||||.|.|:|:..|.:||:.|||::      |:.::.|..
Human   371 ---QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLA------RLIEDNEYT 426

  Fly  1034 AANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPI 1098
            |..              |:::                                          ||
Human   427 ARQ--------------GAKF------------------------------------------PI 435

  Fly  1099 RWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEF 1163
            :|.|||:..|..||.::|:|:|||:|.|:.|.|..||..:..|||:.:|.:|.|...|.|.....
Human   436 KWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL 500

  Fly  1164 YNLMSRCWHKEPHMRPSF--AQSRLE 1187
            ::||.:||.|||..||:|  .|:.||
Human   501 HDLMCQCWRKEPEERPTFEYLQAFLE 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	100/332 (30%)
		PTKc	860..1187	CDD:270623	99/330 (30%)
SRC	XP_016883513.1	SH3_Src	88..149	CDD:212941	13/66 (20%)
		SH2_Src_Src	153..253	CDD:198228	19/144 (13%)
		PTKc_Src	266..542	CDD:270656	104/348 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010