DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and RET

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_066124.1	Gene:	RET / 5979	HGNCID:	9967	Length:	1114	Species:	Homo sapiens

Alignment Length:	430	Identity:	132/430 - (30%)
Similarity:	197/430 - (45%)	Gaps:	105/430 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   816 QAMPMSQAS------QRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEAD 874
            ||.|:|.:|      ..|:..|:...:..|. |.....:|.|.|:.|...||||.||:|.||.|.
Human   681 QAFPVSYSSSGARRPSLDSMENQVSVDAFKI-LEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF 744

  Fly   875 DLSGHFGATRIVAVKTIRACSAQVSLKD---EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYA 936
            .|.|..|.| .||||.::..::...|:|   |.|::::: :|.:|:.|.|||.:..|.:||:|||
Human   745 HLKGRAGYT-TVAVKMLKENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYA 807

  Fly   937 MRGRLLSLLRAARSATNILPASVPGGRSL----------APLSPRTLAGFALDIACGMEYIAGRR 991
            ..|.|...||.:|   .:.|..:..|.|.          ..|:...|..||..|:.||:|:|..:
Human   808 KYGSLRGFLRESR---KVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMK 869

  Fly   992 IVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYIL 1056
            :|||||||||:|:......||.|||:|.|:..|                           ..|:
Human   870 LVHRDLAARNILVAEGRKMKISDFGLSRDVYEE---------------------------DSYV- 906

  Fly  1057 QHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFG 1121
                   .:.||:                          :|::|||.|||..|::||::|:|:||
Human   907 -------KRSQGR--------------------------IPVKWMAIESLFDHIYTTQSDVWSFG 938

  Fly  1122 IVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRL 1186
            ::||||.|||..||..:....:...:..|.|.:.|.....|.|.||.:||.:||..||.||
Human   939 VLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFA---- 999

  Fly  1187 EITRSLHKWVDDDSAASDYMDVS------------GFSED 1214
            :|::.|.|.:   ....||:|::            |.||:
Human  1000 DISKDLEKMM---VKRRDYLDLAASTPSDSLIYDDGLSEE 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	110/341 (32%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	110/339 (32%)
RET	NP_066124.1	Cadherin	172..261	CDD:278457
		PTKc_RET	723..1012	CDD:173631	115/361 (32%)
		Pkinase_Tyr	724..1005	CDD:285015	112/350 (32%)
		Inhibitors binding	805..807		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810