DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tie and fgfr3

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	XP_021336328.1	Gene:	fgfr3 / 58129	ZFINID:	ZDB-GENE-000816-1	Length:	821	Species:	Danio rerio

Alignment Length:	513	Identity:	136/513 - (26%)
Similarity:	221/513 - (43%)	Gaps:	134/513 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   720 MEMRRMNLVTLVLVAVG---VIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDS 781
            :||.|.:....:|:.|.   :..|..:|:.|.|.::..::.             .|..||:|: |
Zfish   372 VEMEREDDYADILIYVTSCVLFILTMVIIILCRMWINTQKT-------------LPAPPVQKL-S 422

  Fly   782 KYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASE- 845
            |:.               ::.........|...:...|:.:.::..::......|..:..|.|:
Zfish   423 KFP---------------LKRQVTVSLESNSSMNSNTPLVRIARLSSSDGPMLPNVSELELPSDP 472

  Fly   846 FHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATR-------IVAVKTIRACSAQVSLKD- 902
            ..:|.|:.:.|...||||.||||..|||      .|..:       .||||.::.......|.|
Zfish   473 KWEFTRTKLTLGKPLGEGCFGQVVMAEA------IGIDKEKPNKPLTVAVKMLKDDGTDKDLSDL 531

  Fly   903 --EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSL 965
              |..:|:.:|.|:|::.|||||.:..|..:::|||.:|.|...|||.|          |.|...
Zfish   532 VSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARR----------PPGMDY 586

  Fly   966 A---------PLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDL 1021
            :         .|:.:.|...|..:|.||||:|.::.:||||||||||:..:.:.||.|||::.|:
Zfish   587 SFDTCKIPNETLTFKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDV 651

  Fly  1022 DAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHG 1086
                               ||...:                                  ||:.:|
Zfish   652 -------------------HNIDYY----------------------------------KKTTNG 663

  Fly  1087 HDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGL 1151
            .        ||::|||||:|...::|.::|:|::|::||||.|||.:||..:...|:.:.:.:|.
Zfish   664 R--------LPVKWMAPEALFDRVYTHQSDVWSYGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH 720

  Fly  1152 RPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVS 1209
            |.|.|....||.|.:|..|||..|..||:|.|...:     |..|...::..:|:|:|
Zfish   721 RMDKPANCTHELYMIMRECWHAVPSQRPTFRQLVED-----HDRVLSMTSTDEYLDLS 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	108/347 (31%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	108/345 (31%)
fgfr3	XP_021336328.1	IGc2	67..121	CDD:197706
		Ig2_FGFR	173..257	CDD:143265
		Ig3_FGFR-2	280..369	CDD:143266
		PTKc_FGFR3	468..801	CDD:173652	118/388 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900