Protein Alignment Tie and fgfr1b

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_001155204.1
• Gene: fgfr1b / 567905
• ZFINID: ZDB-GENE-060503-14
• Length: 740
• Species: Danio rerio
• Alignment Length: 966
• Identity: 211/966 - (21%)
• Similarity: 344/966 - (35%)
• Gaps: 333/966 - (34%)

  Fly   313 TKPAVMGKGIPSKTNSMEDDVEEEEDELKPYVYFGAKLPPIRPGGLTIKAAEGDDDHPRVLEVSV 377
            ::|||..:|....::..|||.|...:|.||  ....:|.|:.|     :.|:     |..:|..:
Zfish    33 SRPAVTEQGHIVASSEDEDDDESSSEENKP--SSSQELLPMAP-----RWAQ-----PEKMEKKL 85

  Fly   378 AQSTTPTITTTSTTPAPVSSTRPTASTRRPLTPVERSRSKYKYHMRERGLVPTAAPPPAAPPAPP 442
                         ...|.|.|                   .|:..:..|              .|
Zfish    86 -------------HAVPASKT-------------------VKFRCQAEG--------------NP 104

  Fly   443 VSRTRYVGSGRPTAGLSDSIQDLKQTESEVAKPVVRRVVQKVSPSSSTPLIITVLSAEEETTVGQ 507
            :.:.|::.:|:      :..:|.:....::.:.:...:::.|.||....  .|.|...|..::..
Zfish   105 IPKLRWLKNGK------EFKRDQRIGGYKLREHMWTIIMESVVPSDKGN--YTCLVENEYGSINH 161

  Fly   508 TEALPTDEST-------TTTSTTTTTEKPSTTTSTSTTTTTPVPSTS--KRTTTN-APLSTTNTP 562
            |..|...|.:       .......|....|.........:.|.|...  |....| :.|.....|
Zfish   162 TYQLDVVERSPHRPILYAGLPANRTAVVGSDVEFVCKVFSDPQPHIQWLKHIRVNGSQLGPDGLP 226

  Fly   563 TTTTSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLIVFCNNT 627
            ......|....||                   :|:.|:::      .|.::.:||........|:
Zfish   227 YVRVLKTAGLNTT-------------------DKEMEVLQ------LRNVSFEDAGEYTCLAGNS 266

  Fly   628 SDCGVTPRTQTQPSHTTDSSPKILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSN-EV 691
              .|:        ||         .:..||.:::                .|||.||.:.|. ||
Zfish   267 --IGI--------SH---------HSAWLTVVKA----------------PTAPSAVPSQSYLEV 296

  Fly   692 YI---------------GIVESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAV------ 735
            .|               .||:..||:..:|.:|.:..::...::.:||.     :.|:|
Zfish   297 LIYCIGFFLIFLMVGIATIVKIRSSSKKSDFNSQLAVHKLAKSIPLRRQ-----ITVSVESSSSL 356

  Fly   736 --GVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQ 798
              ||:        |||    ..|...|.            :|:....|:|::..|
Zfish   357 NSGVM--------LVR----PSRLSSSG------------TPMLSGVSEYELPQD---------- 387

  Fly   799 HMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEG 863
                                |..:.|                          |..:.|...||||
Zfish   388 --------------------PCWEVS--------------------------RERLVLGKPLGEG 406

  Fly   864 NFGQVWKAEADDLSGHFGATRI--VAVKTIRACSAQVSLKD---EANIMRKLGSHQNVVTLLGAC 923
            .||||...||..|... ...||  ||||.:::.:.:..|.|   |..:|:.:|.|:|::.|||||
Zfish   407 CFGQVVMGEAIGLDKD-KPNRITKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGAC 470

  Fly   924 VESEPHMLIMEYAMRGRLLSLLRAARSATNILPASV-----PGGRSLAPLSPRTLAGFALDIACG 983
            .:..|..:|:|:|.:|.|...|||.|      |..:     |....:..:|.:.|...|..:|.|
Zfish   471 TQDGPLYVIVEFASKGNLREYLRARR------PHGMEYCYNPDPLPIESMSIKDLVSCAYQVARG 529

  Fly   984 MEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKF 1048
            |||:|.::.:||||||||||:..:.:.||.|||::.|:                   |:...:
Zfish   530 MEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDV-------------------HHIDYY-- 573

  Fly  1049 DFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTT 1113
                                            ||:.:|.        ||::|||||:|...::|.
Zfish   574 --------------------------------KKTTNGR--------LPVKWMAPEALFDRIYTH 598

  Fly  1114 ETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMR 1178
            ::|:|:||::||||.|||.:||..:...|:.:.:.:|.|.|.|.....|.|.:|..|||..|..|
Zfish   599 QSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLREGHRMDKPSACTQELYLMMKDCWHAVPTQR 663

  Fly  1179 PSFAQSRLEITRSLHKWVDDDSAAS--DYMDVSGFSEDLEHGVVYFNHRISEFECE 1232
            |:|.|...::.|:|       |..|  :|:::|...|.: :..|..|.|.|....|
Zfish   664 PTFKQLVEDLDRTL-------SLISNQEYLELSVPLEPM-YSQVILNERSSTCSSE 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	108/338 (32%)
fgfr1b	NP_001155204.1	IgI_2_FGFR	73..167	CDD:409443	21/157 (13%)
		Ig strand A	73..76	CDD:409443	1/7 (14%)
		Ig strand A'	84..89	CDD:409443	0/17 (0%)
		Ig strand B	93..101	CDD:409443	2/26 (8%)
		Ig strand C	107..112	CDD:409443	1/4 (25%)
		Ig strand C'	115..117	CDD:409443	0/7 (0%)
		Ig strand D	126..129	CDD:409443	0/2 (0%)
		Ig strand E	133..138	CDD:409443	0/4 (0%)
		Ig strand F	147..154	CDD:409443	2/8 (25%)
		Ig strand G	157..167	CDD:409443	2/9 (22%)
		Ig	175..278	CDD:472250	21/146 (14%)
		Ig strand B	193..197	CDD:409353	0/3 (0%)
		Ig strand C	206..210	CDD:409353	0/3 (0%)
		Ig strand E	244..248	CDD:409353	1/9 (11%)
		Ig strand F	258..263	CDD:409353	0/4 (0%)
		Ig strand G	271..274	CDD:409353	1/11 (9%)
		Protein Kinases, catalytic domain	383..684	CDD:473864	117/431 (27%)