Protein Alignment Tie and pdgfrb

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: XP_021336701.1
• Gene: pdgfrb / 559529
• ZFINID: ZDB-GENE-030805-2
• Length: 1072
• Species: Danio rerio
• Alignment Length: 976
• Identity: 210/976 - (21%)
• Similarity: 332/976 - (34%)
• Gaps: 332/976 - (34%)

  Fly   423 RERGLVPTAAPPPAAPPAPPVSRTRY--------VGSGRPTAGLSDSIQDL----------KQTE 469
            ||.|.:|.....|:      ::.|.|        .||..|:.|.|.::.|.          ::.|
Zfish   139 REEGTIPCLVTNPS------INVTLYERDTEMAVEGSYNPSVGYSAALDDRTYICKGELNGEEKE 197

  Fly   470 SEVAKPVVRRVVQKVSPSSSTPLI---ITVLSAEE----ETTVGQTEAL---------------P 512
            |::.     .|...::|.:..|.|   .|||...|    ..||...|.:               |
Zfish   198 SDLF-----YVFSILAPEALDPYINASKTVLKQGETLNVNCTVHGVELVFFSWDFPNKDMGGIEP 257

  Fly   513 TDESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTTS 577
            ..:..::.|..:.......:...|......|....:....:|.::.|.......|.|.|.....|
Zfish   258 LTDVLSSMSMRSCLNITDVSLDRSGQYVCHVHEGVQDQRASASINITVLEKGFVSLTPPLDRNIS 322

  Fly   578 S---------TSTTVIPTTT----KANSII-------EKDKELIRALGPALTR---------EIN 613
            :         ......|..|    |..::|       |.:...:..|....||         .:.
Zfish   323 AQLGENVELKVEIEAYPKPTVQWRKDGAVIRGHSMREEHETRFVSTLTLVRTRLQQMGLYKVTVQ 387

  Fly   614 IDDANNLIVFCNNTSDCGVTPR-TQTQPSHTTDSSPKILRTTVLTSIRSTVHPRP---------- 667
            .:||...::|   ..:..|.|: |:....|..:....:  |.|...:     |:|
Zfish   388 NEDALKEMIF---DLEVKVPPQITELSDHHLPEKKHAV--TCVAEGV-----PKPSIQWFSCDSM 442

  Fly   668 ---TSTSTTTSTTTTAPPAVTAPSNEVYIGIVESSSSASPADISSTV-------------IANER 716
               ::.|...|.....|.:||..:|..|      :|:.....:.|.|             .:|||
Zfish   443 TRCSNRSAVWSPLVEDPESVTIQTNVTY------NSTRKIHQVLSQVTLVRPQLLTIRCEASNER 501

  Fly   717 DLN-MEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVK-KV 779
            ... .::|.:|......|||....||.:::.::...::           :.:..::|...:: ||
Zfish   502 GARARDIRLVNSTLFSQVAVLAAVLALVVIVIISIIIL-----------IAVWRKKPRYEIRWKV 555

  Fly   780 DSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLAS 844
            .....:|                        .|::....|:         |..|       .||.
Zfish   556 IESVSLD------------------------GHEYIYVDPI---------HLPY-------DLAW 580

  Fly   845 EFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRAC---SAQVSLKDEANI 906
            |   ..|.::.|...||.|.||:|.:|.|..|.....||: ||||.:::.   |...:|..|..|
Zfish   581 E---MPRDSLVLGRTLGSGAFGRVVEATAYGLGISQSATK-VAVKMLKSTARRSETQALMSELKI 641

  Fly   907 MRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAAR--------------SATNILPA 957
            |..||.|.|:|.|||||.:..|..|:.||...|.|:..|...:              :.|.|...
Zfish   642 MSHLGPHINIVNLLGACTKQGPLYLVTEYCRYGDLVDYLHRNKHSFLQNFADKNHIANGTQICND 706

  Fly   958 S----------------------------VP------------------------------GGR- 963
            |                            ||                              |.|
Zfish   707 SDSGKEYVSFGSECDGGYMDMTKDEQTEYVPMQELADTIKYADIQPSPYESPYQQDIYQEQGHRV 771

  Fly   964 ------SLAP-LSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDL 1021
                  |.:| ||...|.||:..:|.|||::|.:..|||||||||||:....:.||||||:
Zfish   772 DHSLVISDSPVLSYTDLVGFSYQVAQGMEFLASKNCVHRDLAARNVLICEGKLAKICDFGL---- 832

  Fly  1022 DAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHG 1086
                         |.|:|..|.:..|   ||.:
Zfish   833 -------------ARDIMHDNNYISK---GSTF-------------------------------- 849

  Fly  1087 HDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVI-RRVPQG 1150
                     ||::||||||:.::::||.:|:|::||:||||.|||.|||..|...|:. ..:.:|
Zfish   850 ---------LPLKWMAPESIFHNLYTTLSDVWSYGILLWEIFTLGGTPYPDLPMNELFYSALKRG 905

  Fly  1151 LRPDLPKESRHEFYNLMSRCWHKEPHMRPSFA-------QSRLEITRSLHKWVDDDSAASDYMDV 1208
            .|...|..:..|.|.:|.:||.::...||.|:       ....:..:..:..|:|....||:..|
Zfish   906 YRMAKPSYASDEIYEVMRKCWDEKYEKRPEFSFLVHTMGNMLSDAYKKKYSQVNDSFLKSDHPAV 970

  Fly  1209 S 1209
            :
Zfish   971 A 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	118/419 (28%)
pdgfrb	XP_021336701.1	Ig	212..305	CDD:472250	14/92 (15%)
		Ig strand B	229..233	CDD:409447	0/3 (0%)
		Ig strand C	242..246	CDD:409447	0/3 (0%)
		Ig strand E	269..273	CDD:409447	0/3 (0%)
		Ig strand F	283..288	CDD:409447	0/4 (0%)
		Ig strand G	298..301	CDD:409447	1/2 (50%)
		Ig	309..403	CDD:472250	15/96 (16%)
		Ig strand B	329..333	CDD:409445	0/3 (0%)
		Ig strand C	342..346	CDD:409445	1/3 (33%)
		Ig strand E	367..371	CDD:409445	1/3 (33%)
		Ig strand F	381..386	CDD:409445	0/4 (0%)
		Ig strand G	394..397	CDD:409445	0/2 (0%)
		Ig_3	404..499	CDD:464046	17/107 (16%)
		Protein Kinases, catalytic domain	549..947	CDD:473864	129/502 (26%)