DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and kdr

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001019824.2	Gene:	kdr / 554230	ZFINID:	ZDB-GENE-041001-112	Length:	1357	Species:	Danio rerio

Alignment Length:	971	Identity:	210/971 - (21%)
Similarity:	345/971 - (35%)	Gaps:	324/971 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 DDHPRVLEVSVA-------QSTTPTITTT-STTPAPVSSTRPTASTRRPLTPVERSRSKYKYHMR 423
            :|.||:.|..|:       ..::||:|.| |...:||:                   .|:::..|
Zfish   430 NDLPRIFEKDVSLDRDVHMYGSSPTLTCTGSGGSSPVT-------------------IKWQWMPR 475

  Fly   424 ERGLVPTAAPPPAAPPAPPVSRTRYVGSG---RPTAGLSD-------SIQDLK------------ 466
            |.  .|....|.:.|......:.|.:.:.   .|....:.       :|..||
Zfish   476 ED--CPVRFLPKSDPSMAKCDKWREMSNNTGKNPLISQTSVDERTLKTISTLKIQKAVDHALYRC 538

  Fly   467 -------QTESEVAKPVVRRVVQKVSPSSS-------------TPLIITVLSAEEETTVGQTE-- 509
                   |.:..:...|.|.:...|.||||             ..|:...|.......|...:
Zfish   539 IATNKMGQDQRVIVFQVTRFLNLSVLPSSSPIEGQDVIMRCVADRLLYYNLRWYRVANVANHDPP 603

  Fly   510 --ALPTDESTTTTSTTTTTEKPSTTTS----TSTTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSS 568
              |:|.|     |.|.:...:|:.|.|    |:.|...|:|:.   |..:..|.........|:.
Zfish   604 PAAVPCD-----TLTLSHLHQPNVTVSGLQGTNVTLDMPIPNA---TMMDQGLYACQVEIVGTNE 660

  Fly   569 TTPSTTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLIVFCNNTSDCGVT 633
                             .|...:::..:..|:.|.:.....:.:|:.|:..|:...:.|.    |
Zfish   661 -----------------KTCLLHNLRLRALEMSRIVTNLTDQRVNVSDSTTLVCEVSGTP----T 704

  Fly   634 PR-TQTQPSHTT-DSSPKILRTT--VLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEVYIG 694
            |. ..|:.:.|. :.|..||:.:  |||..|                       |....:.:||.
Zfish   705 PTIVWTKDNQTVMEGSGVILKRSNRVLTIQR-----------------------VKKEDSGLYIC 746

  Fly   695 IVESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQ 759
            ...:......::...:|...|..:|:|:         ::.:|.: :.|:.|:|:..||||.|.:.
Zfish   747 TACNQQGCESSEARISVDGAEEKMNVEL---------IMPIGAV-VIAMFLWLLIVFVIRNRKRP 801

  Fly   760 SEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQAS 824
            ::            ..:|.......:|.|:                            |||.:..
Zfish   802 ND------------GDLKTGYLSIILDSDD----------------------------MPMDEHC 826

  Fly   825 QRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVK 889
            :|            .|..||:: :|.|..::|...||.|.||||.:|.|..:......| .||||
Zfish   827 ER------------LTYDASKW-EFPRDRLKLGEPLGRGAFGQVVEATAYGIEKATTCT-TVAVK 877

  Fly   890 TIR--ACSAQV-SLKDEANIMRKLGSHQNVVTLLGACV-ESEPHMLIMEYAMRGRLLSLLRAARS 950
            .::  |.|::. :|..|..|:..:|.|.|||.|||||. :..|.|:|:||...|.|.|.|::.|.
Zfish   878 MLKEGATSSEYRALMSELKILIHIGHHLNVVNLLGACTKQGGPLMVIVEYCKHGNLSSYLKSKRG 942

  Fly   951 ATNILPASVP----------------GGRSLAP-------------------------------- 967
            ..:......|                |...|..
Zfish   943 EYSPYKKRTPRMPNRREVQQDEDPREGDLGLGTSTRLDICTGTAVCTRTGEQTSTTLQDEQESSD 1007

  Fly   968 ---LSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDL--DAERMR 1027
               |:...|..::..:|.|||::|.|:.:||||||||:||..|.:.||||||::.|:  |.:.:|
Zfish  1008 WDHLTMEDLISYSFQVAKGMEFLASRKCIHRDLAARNILLSENSVVKICDFGLARDVYKDPDYVR 1072

  Fly  1028 KEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGK 1092
            |                                                  |:.:
Zfish  1073 K--------------------------------------------------GDAR---------- 1077

  Fly  1093 RHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQL-TGREVIRRVPQGLRPDLP 1156
               ||::|||||::...::||::|:|:||::||||.:||::||..: ......||:.:|.|...|
Zfish  1078 ---LPLKWMAPETIFDRVYTTQSDVWSFGVLLWEIFSLGASPYPGVCIDESFCRRLKEGTRMRAP 1139

  Fly  1157 KESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVSG--FSEDL 1215
            ..:..|.|..|..||...|..||:|.|....:...|......|  ..||:.::.  ..|:|
Zfish  1140 DYATPEIYQTMLDCWLDRPLDRPTFTQLVEHLGNLLQASAQQD--GKDYIPLTNGEMEEEL 1198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	108/386 (28%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	108/384 (28%)
kdr	NP_001019824.2	Ig_2	143..221	CDD:290606
		IG_like	233..331	CDD:214653
		Ig	241..335	CDD:299845
		IG_like	345..429	CDD:214653
		Ig2_VEGFR-2	356..429	CDD:143272
		IG	571..654	CDD:214652	17/90 (19%)
		Ig	571..654	CDD:299845	17/90 (19%)
		I-set	677..763	CDD:254352	19/112 (17%)
		IGc2	691..753	CDD:197706	17/88 (19%)
		PKc_like	835..1178	CDD:304357	112/407 (28%)
		Pkinase_Tyr	843..1171	CDD:285015	109/391 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	944..975		3/30 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1296..1357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900