Protein Alignment Tie and STYK1

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_060893.2
• Gene: STYK1 / 55359
• HGNCID: 18889
• Length: 422
• Species: Homo sapiens
• Alignment Length: 484
• Identity: 99/484 - (20%)
• Similarity: 183/484 - (37%)
• Gaps: 135/484 - (27%)

  Fly   727 LVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKV-DSKYQVDDDED 790
            |||:.|:.:||      ||:|   |:..:|.:|..      :..|.|:||... |..::.
Human    33 LVTIFLILLGV------ILWL---FIREQRTQQQR------SGPQGIAPVPPPRDLSWEA----- 77

  Fly   791 EVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDD---KTSLASEFHDFERS 852
                                .|..:.|:|:.:.|.    .|..|....   |..:..|
Human    78 --------------------GHGGNVALPLKETSV----ENFLGATTPALAKLQVPRE------- 111

  Fly   853 NIRLKSLLGE---GNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVSLKD---EANIMRKLG 911
              :|..:|.:   |:.|.:::|..:  :|.....:.|.:|.::..:....::|   .....:.||
Human   112 --QLSEVLEQICSGSCGPIFRANMN--TGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLG 172

  Fly   912 SHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGF 976
            .|:|:|.|.|.|.|..|..:::|...:|.|||.|...|.....:..      .|..|:.:.:...
Human   173 KHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDG------LLYDLTEKQVYHI 231

  Fly   977 ALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRH 1041
            ...:...:|::..:.:.|.|:||||:|:..:...|:|..|::.::
Human   232 GKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEV-------------------- 276

  Fly  1042 NAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESL 1106
                               :|.|                        .|.....:|::|:|||.|
Human   277 -------------------YTRG------------------------AISSTQTIPLKWLAPERL 298

  Fly  1107 QYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCW 1171
            .....:...|:|:|||:|:|:.|||:.||.::....::..:.:......|....|..|::|..||
Human   299 LLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCW 363

  Fly  1172 HKEPHMRPSFAQSRLEITRSLHKWVDDDS 1200
            ......|||..:.||.:..:: |..||::
Human   364 RWREADRPSPRELRLRLEAAI-KTADDEA 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	69/334 (21%)
		PTKc	860..1187	CDD:270623	69/332 (21%)
STYK1	NP_060893.2	Pkinase_Tyr	117..380	CDD:285015	70/333 (21%)
		PKc_like	118..381	CDD:304357	69/333 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900