DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and hck

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001015722.1	Gene:	hck / 548439	XenbaseID:	XB-GENE-6048191	Length:	498	Species:	Xenopus tropicalis

Alignment Length:	343	Identity:	103/343 - (30%)
Similarity:	156/343 - (45%)	Gaps:	88/343 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   848 DFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACS-AQVSLKDEANIMRKLG 911
            :..|.::.|:..||.|.||.||.|   ..:||    ..|||||::|.| :..:..:|||:|:.|
Frog   227 EIPRESLSLQKKLGTGQFGDVWLA---TYNGH----TEVAVKTMKAGSMSPAAFLEEANLMKSL- 283

  Fly   912 SHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGF 976
            .|:.:|.|.....:.||..::.||..:|.||..|::            |.| |..|::  .|..|
Frog   284 QHERLVRLHAVVTQGEPIYIVTEYMHKGSLLDFLKS------------PEG-SRQPVT--QLIDF 333

  Fly   977 ALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRH 1041
            ...||.||.:|..|..:||||.|.|.|:....:|||.|||::      |:.::.|..|..
Frog   334 CAQIAEGMWFIEQRNYIHRDLRAANCLVSETLLCKIADFGLA------RVIEDSEYTARE----- 387

  Fly  1042 NAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESL 1106
                     ||::                                          ||:|.:||:.
Frog   388 ---------GSKF------------------------------------------PIKWTSPEAA 401

  Fly  1107 QYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCW 1171
            .|..||.::|||:||::|.||.|.|.:||..::..||:..:.:|.|...|.....|.|.:|.:||
Frog   402 NYGSFTIKSDIWSFGVLLSEIMTYGRSPYPGMSNSEVMAALERGYRMPCPGTCPTELYGIMLQCW 466

  Fly  1172 HKEPHMRPSF--AQSRLE 1187
            .::||.||:|  .|:.||
Frog   467 QQDPHKRPTFEYLQNILE 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	99/331 (30%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	99/329 (30%)
hck	NP_001015722.1	SH3	57..112	CDD:388381
		SH2_Src_family	115..211	CDD:199827
		PTKc_Src_like	237..484	CDD:270630	99/331 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010