Protein Alignment Tie and flt1

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_001014829.3
• Gene: flt1 / 544667
• ZFINID: ZDB-GENE-050407-1
• Length: 1272
• Species: Danio rerio
• Alignment Length: 1117
• Identity: 241/1117 - (21%)
• Similarity: 379/1117 - (33%)
• Gaps: 371/1117 - (33%)

  Fly   250 FTRMAMPSNGNSSVVLKGSASLKAAAPAGDRDTN-EILFSDESSHGLFVVAKEQNGTLNHIADGT 313
            ::.:.:||...:.   ||....:..:....|:|| .::..|:.    |:..|.:||.:.....|.
Zfish   285 YSVLTIPSLSKAD---KGLYKCQVTSGPSKRETNTTVIVYDQP----FIRLKHRNGPVVQAFAGQ 342

  Fly   314 K-----PAVMGKGIPSKTNSMEDDVEEEEDELKPYVYFGAKLPPIRPGGLTIKAAEGDDDHPRVL 373
            |     |.:  |..|:.......|.....:....|...|..| .||      ..||.|.....:|
Zfish   343 KSFRLTPKL--KAFPAPEIIWLKDGMVAAERCSRYHVDGFSL-VIR------DVAEEDAGIYTIL 398

  Fly   374 ----EVSVAQSTTPTITTTSTTPAPVSSTRP-----TASTRRPLTPVERSRSKYKYHMRERGLVP 429
                :..:.|:.|.|:         |.:.:|     :.|:::|.| |:|. |:...|....|:
Zfish   399 TGIQQYGLFQNLTITL---------VVNVKPQIGEKSVSSQQPGT-VQRG-SRQALHCTSHGV-- 450

  Fly   430 TAAPPPAAP----PAPPVSRTRYVGSGRPTAGLSDSIQDLKQTESEVAKPVVRRVVQKVSPSSST 490
               |||...    |.||             .||           .|...|.....|:|.:..:||
Zfish   451 ---PPPQIQWLWHPCPP-------------KGL-----------CEKPPPSSWTAVRKKTGVTST 488

  Fly   491 PLIITVLSAEEETTVGQT---------EALPTDESTTTTS---------------------TTTT 525
            ...|..:|..:|...|:.         |||.:......||                     ..:.
Zfish   489 HNPILTISHRQEVLEGKNKTVGVLTVGEALVSGIYRCVTSNILGRDELDIPFYVTDVKEGLVASL 553

  Fly   526 TEKP--------------------STTTSTSTTTTTPVPSTSKRTTTNAPLSTT----------- 559
            .|:|                    |.:..||..|.....|......|....|.|
Zfish   554 VEEPREGGDLRLLCIANRHLYSDLSWSRITSQITVWDEASGLDGELTEGQFSHTLHFGLKNLTAR 618

  Fly   560 NTPTTTTSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLIVFC 624
            ::.|...|:|...|.......|.|..|..:|..:          ||......:|:  :|::.:.|
Zfish   619 DSGTYRCSATHLLTGEHIHLDTAVEVTVLQAPVL----------LGNLSDHTVNV--SNSITLHC 671

  Fly   625 NNTSDCGVTPRTQTQPSHTTDSSPKILRTT---VLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTA 686
                    ..|...||..|...:.:.|:..   :|.....|:|....:.......|..|.....:
Zfish   672 --------PARGVPQPHITWYKNQRKLQQVSGIMLFPEEGTLHIDRITVEDQGFYTCQATNQRGS 728

  Fly   687 PSNEVYIGIVESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNF 751
            ..:..||.:..||.|.|                     :.:.||....|     .|.:.:|:...
Zfish   729 VESSAYIWVQNSSESLS---------------------LEIPTLACTCV-----VATLFWLLLTL 767

  Fly   752 VIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQ--- 813
            :||:                                                ..|.|..|.:
Zfish   768 LIRK------------------------------------------------LKHPNSDNGKAEY 784

  Fly   814 -----HHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEA 873
                 |....|:.:             :.|:........:|.|..::|:..||.|.||:|.:|.|
Zfish   785 LPIILHPGEEPLVE-------------HCDRLQYDPAKWEFPRDRLKLEKPLGRGAFGRVMQASA 836

  Fly   874 DDLSGHFGATRIVAVKTIR---ACSAQVSLKDEANIMRKLGSHQNVVTLLGACVES-EPHMLIME 934
            ..: |:..:...||||.::   ..|...:|..|..|:..:|.|.|||.|||||.:| .|.|:|:|
Zfish   837 VGI-GNSASCTTVAVKMLKDGATPSEHKALMTELKILNHIGHHINVVNLLGACTKSGGPLMVIVE 900

  Fly   935 YAMRGRLLSLLRAARSA----------TNILP-------ASVPGGRSLA---------------- 966
            |...|.|.:.|::.|..          ..::.       .||...:|.|
Zfish   901 YCQFGNLSAYLKSKREVFLLNRVNKEEEGVMKEGCKGRLTSVSSRQSNASSGFSEERGEISEEDS 965

  Fly   967 --------PLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDL-- 1021
                    ||....|..::..:|.|||::|.|:.:||||||||:||.:|.:.||||||::.||
Zfish   966 DCLSELSDPLLLEDLISYSFQVARGMEFLASRKCIHRDLAARNILLSNNNVVKICDFGLARDLYK 1030

  Fly  1022 DAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHG 1086
            |.:.:|                                                  :|:.:
Zfish  1031 DPDYVR--------------------------------------------------NGDAR---- 1041

  Fly  1087 HDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLT-GREVIRRVPQG 1150
                     ||::||||||:...:|||::|:|::|::||||.:||::||..|. ..|..||:..|
Zfish  1042 ---------LPLKWMAPESIFDKVFTTQSDVWSYGVLLWEIFSLGASPYPGLNMDEEFCRRLKHG 1097

  Fly  1151 LRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRS-LHKWVDDDSAASDYMDVSGFSED 1214
            .|...|:.|..|.|::|..||...|..||||. :.:||... |...|..|  ..||:.::.|...
Zfish  1098 TRMCSPQYSTPEIYSIMCACWENNPEDRPSFT-TLVEILGDLLQTCVQQD--GKDYIPLNAFKSG 1159

  Fly  1215 LEHGV-VYFNHR 1225
            ..|.: .:.|.|
Zfish  1160 EGHTITTHLNQR 1171

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	113/376 (30%)
		PTKc	860..1187	CDD:270623	112/374 (30%)
flt1	NP_001014829.3	Ig	238..321	CDD:386229	7/38 (18%)
		Ig_VEGFR-1	345..416	CDD:143326	16/88 (18%)
		Ig_3	426..529	CDD:372822	30/133 (23%)
		IG	558..646	CDD:214652	14/87 (16%)
		I-set	650..733	CDD:369462	15/102 (15%)
		PTKc_VEGFR	809..1138	CDD:270647	117/393 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900