DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and Flt1

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_062179.2	Gene:	Flt1 / 54251	RGDID:	2621	Length:	1336	Species:	Rattus norvegicus

Alignment Length:	1320	Identity:	290/1320 - (21%)
Similarity:	449/1320 - (34%)	Gaps:	458/1320 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 VALLLAEAIVAA---AAATLSETQTNATNGAIREPPVQLQLQQQQLQLQLQLNAT-AGDGESRNS 137
            :.||..||.|..   ..:.|:..|||........||..::..:.|   .|.||.| ..|..:|..
  Rat   202 IGLLTCEATVNGHLYQTSYLTHRQTNTILDVQISPPSPVRFLRGQ---TLVLNCTVTTDLNTRVQ 263

  Fly   138 AEIFSPGDVDVVGDKPTTYRPSGANR-----------PSIAPLNSAQDRERKLMNVLAARRTALH 191
            .....||        ..|.|.|...|           .|:..:|:.:.|::.|...
  Rat   264 MSWNYPG--------KATKRASIRQRIDQSNPHSNVFHSVLKINNVESRDKGLYTC--------- 311

  Fly   192 RGGFRTRIGTTGRTAISPSAAVESTSKAPSDPRSVCIRNCTKNFTRRTTASCMRQCANFTRMAMP 256
                |.:.|::.||.        :||....:...:.::: .|...:.|.|.......:....|.|
  Rat   312 ----RVKSGSSFRTF--------NTSVHVYEKGFISVKH-RKQQVQETIAGKRSHRLSMKVKAFP 363

  Fly   257 SNGNSSVVLKGSASLKAAAPAGDRDTNEILFSDESSHGLFVVAKEQNGTLNHIAD-----GTKPA 316
            |   ..||.     ||...||.::...      .|.||..::.|:.  |.....|     |.|.:
  Rat   364 S---PEVVW-----LKDGVPATEKSAR------YSVHGYSLIIKDV--TAEDAGDYTILLGIKQS 412

  Fly   317 VMGKGIPSKTNSMEDDVEEEEDELKPYVY----FGAKLPPIRPGGLTIKAAEGDDDHPRVLEVSV 377
            .:.:.:   |.::..:|       ||.:|    .....||:.|.|           ..:||..:|
  Rat   413 KLFRNL---TATLIVNV-------KPQIYEKSVSSLPSPPLYPLG-----------SRQVLTCTV 456

  Fly   378 AQSTTPTITTTSTTPAPVSSTRPTASTRRPLTPVERSRSKYKYHMRERGLVPTAAPPPAAPPAPP 442
            .....|||... ..|...:.:              :.|:.:.:...|..::.:::
  Rat   457 YGIPQPTIKWL-WHPCHYNHS--------------KERNDFCFGSEESFILDSSS---------- 496

  Fly   443 VSRTRYVGSGRPTAGLSDSIQDLKQTESEVAKPVVRRVVQKVSPSSSTPLIITVLSAEEETTVGQ 507
                   ..|....|::..:..::.|...|:..||        ..|.||.|.:..:..:..||.:
  Rat   497 -------NIGNRIEGITQRMMVIEGTNKTVSTLVV--------ADSRTPGIYSCKAFNKIGTVER 546

  Fly   508 ----------------TEALPTDESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNAPL 556
                            .|.:||:......|..                   |.....|..|...|
  Rat   547 DIRFYVTDVPNGFHVSLEKIPTEGEDLKLSCV-------------------VSKFLYRDITWILL 592

  Fly   557 STTNTPTTTTSSTTPSTTTTSSTSTT---VIPTTTKANS---------------IIEKDKELIRA 603
            .|.|..|...|.:.....||...|.|   ||...:..:|               |:.|.:.|:|.
  Rat   593 RTVNNRTMHHSISKQKMATTQDYSITLNLVIKNVSLEDSGTYACRARNIYTGEEILRKTEVLVRD 657

  Fly   604 L-GPALTREINIDDANNLIVFCNNTSDC---GV-TPR-TQTQPSHTTDSSPKILRTTVLTSIRST 662
            | .|.|.:  |:.| :.:.:..:.|.||   || .|: |..:.:|.....|.|:
  Rat   658 LEAPLLLQ--NLSD-HEVSISGSTTLDCQARGVPAPQITWFKNNHKIQQEPGII----------- 708

  Fly   663 VHPRPTSTSTTTSTTTTAPPAVTAPSNEVY-------IGIVESSSSASPADISSTVIANERDLNM 720
            :.|         ..:|.....||.....||       .|:||||:..       ||.......|:
  Rat   709 LGP---------GNSTLFIERVTEEDEGVYRCRATNQKGVVESSAYL-------TVQGTSDKSNL 757

  Fly   721 EMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQV 785
            |     |:||....|     ||.:.:|:....||:..:.|             |.||.......:
  Rat   758 E-----LITLTCTCV-----AATLFWLLLTLFIRKLKRSS-------------SEVKTDYLSIIM 799

  Fly   786 DDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFE 850
            |.||..:|.|                   .:.:|..                     ||:: :|.
  Rat   800 DPDEVPLDEQ-------------------CERLPYD---------------------ASKW-EFA 823

  Fly   851 RSNIRLKSLLGEGNFGQVWKAEADDLSGHFG-----ATRIVAVKTIR---ACSAQVSLKDEANIM 907
            |..::|...||.|.||:|.:|.|      ||     ..|.||||.::   ..|...:|..|..|:
  Rat   824 RERLKLGKSLGRGAFGKVVQASA------FGIKKSPTCRTVAVKMLKEGATASEYKALMTELKIL 882

  Fly   908 RKLGSHQNVVTLLGACV-ESEPHMLIMEYAMRGRLLSLLRAAR--------SATNILP------- 956
            ..:|.|.|||.|||||. :..|.|:|:||...|.|.:.|::.|        :|.::.|
  Rat   883 THIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDFFCLNKDAALHMEPKKEKLEP 947

  Fly   957 ------------------------------ASVPGGR-----SLAPLSPRTLAGFALDIACGMEY 986
                                          :.|.||.     |..||:...|..::..:|.|||:
  Rat   948 DLEQDQKPRLDSVSSSESFTSSGFQEDKSVSDVEGGEDYSEISKQPLTMEDLISYSFQVARGMEF 1012

  Fly   987 IAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFG 1051
            ::.|:.:||||||||:||..|.:.||||||::.|:         .||.  |.:|..
  Rat  1013 LSSRKCIHRDLAARNILLSENNVVKICDFGLARDI---------YKNP--DYVRRG--------- 1057

  Fly  1052 SRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETD 1116
                                                ||     .||::||||||:...:::|::|
  Rat  1058 ------------------------------------DT-----RLPLKWMAPESIFDKVYSTKSD 1081

  Fly  1117 IWAFGIVLWEIATLGSTPYSQL-TGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPS 1180
            :|::|::||||.:||.:||..: ...:...|:.:|:|...|:.:..|.|.:|..||||:|..||.
  Rat  1082 VWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKERPR 1146

  Fly  1181 FAQSRLEITRSLHKWVDDDSAASDYM--------------DVSGFSEDL--------------EH 1217
            ||:...::...|...|..|  ..||:              .|..||||.              ..
  Rat  1147 FAELVEKLGDLLQANVQQD--GKDYIPLNAILTRNSGFTYSVPTFSEDFFKDGFTDPKFHSGSSD 1209

  Fly  1218 GVVYFN-------HRISEFE 1230
            .|.|.|       .||..||
  Rat  1210 DVRYVNAFKFMSLERIKTFE 1229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	112/388 (29%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	112/386 (29%)
Flt1	NP_062179.2	IG_like	143..219	CDD:214653	5/16 (31%)
		IG_like	237..328	CDD:214653	24/122 (20%)
		Ig	245..327	CDD:299845	23/113 (20%)
		Ig	353..424	CDD:299845	18/89 (20%)
		IG_like	439..552	CDD:214653	25/163 (15%)
		Ig	451..549	CDD:143165	21/137 (15%)
		IG	568..640	CDD:214652	17/90 (19%)
		IGc2	569..640	CDD:197706	16/89 (18%)
		I-set	661..748	CDD:254352	25/116 (22%)
		IGc2	676..738	CDD:197706	16/81 (20%)
		PKc_like	819..1157	CDD:304357	115/405 (28%)
		Pkinase_Tyr	827..1154	CDD:285015	113/393 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900