Protein Alignment Tie and FGFRL1

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: XP_024309860.1
• Gene: FGFRL1 / 53834
• HGNCID: 3693
• Length: 527
• Species: Homo sapiens
• Alignment Length: 422
• Identity: 78/422 - (18%)
• Similarity: 132/422 - (31%)
• Gaps: 95/422 - (22%)

  Fly   315 PAVMGKGIP--------------SKTNSMEDDVEEEEDELKPY------VYFGAKLPPIRPGGLT 359
            ||...:|.|              .:|..::..||.:...|..:      ::.|.....:.|.||.
Human    44 PAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLK 108

  Fly   360 IKAAEGDDDHPRVLEVS---VAQSTTPTITTTSTTPAPVSSTRPTASTRRPLTPVERSRSKYKY- 420
            :|..|.:|....|.:.:   .:.|...|:...........|..|.:|:.....|..:..::.::
Human   109 VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFT 173

  Fly   421 ---HMRERGLVPTAAPPPAAPPAPPVSRTRYVGSGRPTAGLSDSIQDLKQTESEVAKPVVRR--- 479
               .||.|.:         |.|.....|.:.|.||.|...::....|...|..|.|:|..::
Human   174 QPSKMRRRVI---------ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 229

  Fly   480 VVQKVSPSSSTPLIITVLSAEEETTVGQTEALPTDESTTTTSTTTTTEKPSTTTSTSTTTT---- 540
            .::.:.|..|......|  :.....:..|..:...:.|.:....|.|...:||.....||:
Human   230 SLKNLRPEDSGKYTCRV--SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCK 292

  Fly   541 -----TPVPSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPT----TTKANSIIEK 596
                 .||....||....|            .....||.........|:||    :....|.:.|
Human   293 VRSDVKPVIQWLKRVEYGA------------EGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNK 345

  Fly   597 DKELIRALGPALTREINIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTDSSPKILRTTVLTSIRS 661
                      .|......|||...|  |...:..|.:                 .|:..||.:..
Human   346 ----------LLITRARQDDAGMYI--CLGANTMGYS-----------------FRSAFLTVLPD 381

  Fly   662 TVHPRPTSTSTTTSTTTTAPPAVTAPSNEVYI 693
            ...|.|...|::::|:...|..:..|:..|:|
Human   382 PKPPGPPVASSSSATSLPWPVVIGIPAGAVFI 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581
		PTKc	860..1187	CDD:270623
FGFRL1	XP_024309860.1	I-set	56..139	CDD:254352	14/82 (17%)
		Ig2_FGFRL1-like	180..261	CDD:143264	17/91 (19%)
		Ig	284..378	CDD:325142	23/134 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900