DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and PDGFRB

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_002600.1	Gene:	PDGFRB / 5159	HGNCID:	8804	Length:	1106	Species:	Homo sapiens

Alignment Length:	943	Identity:	213/943 - (22%)
Similarity:	323/943 - (34%)	Gaps:	343/943 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 TRPTASTRRPLTPVERSRSKYKYHMRERGLVPTAAPPPAAPPAPPVSRTRYVGSGRPTAGLSDSI 462
            |.|...:.|.:.||........||:|....:|:|               ....||..|..:::|:
Human   248 TYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSA---------------ELEDSGTYTCNVTESV 297

  Fly   463 QDLKQTESEVAKPVVR---------------------RVVQKVSPSSSTPLIITVLSAEEETTVG 506
            .| .|.|..:...||.                     |.:|.|..:...|   |||..::..|:|
Human   298 ND-HQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPP---TVLWFKDNRTLG 358

  Fly   507 QTEALPTDESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNAPLSTT-----NTPTTT- 565
            .:.|   .|...:|...:.|...|..|............|.:....:|.:..:     |.|...
Human   359 DSSA---GEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVL 420

  Fly   566 -TSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLIVFCNNTSD 629
             .|.:.|                       :..::.:|..|..:.:      .|.:...|.:...
Human   421 ELSESHP-----------------------DSGEQTVRCRGRGMPQ------PNIIWSACRDLKR 456

  Fly   630 CGVTPRTQTQPSHTTDSSPK--ILRTT-----------VLTSIRSTVHPRPTSTSTTTSTTTTAP 681
            |   || :..|:...:||.:  .|.|.           |::::|.....||.|...|...
Human   457 C---PR-ELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRN----- 512

  Fly   682 PAVTAPSNEVYIGIVESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILY 746
             ||...:.||   ||...|......:.|.::|             ||.|.::::.::    |:|:
Human   513 -AVGQDTQEV---IVVPHSLPFKVVVISAILA-------------LVVLTIISLIIL----IMLW 556

  Fly   747 LVR-NFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQ 810
            ..: .:.||.:..:|                        |..|
Human   557 QKKPRYEIRWKVIES------------------------VSSD---------------------- 575

  Fly   811 NHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADD 875
            .|::....||....             |.|      .:..|..:.|...||.|.||||.:|.|..
Human   576 GHEYIYVDPMQLPY-------------DST------WELPRDQLVLGRTLGSGAFGQVVEATAHG 621

  Fly   876 LSGHFGATRIVAVKTIRA---CSAQVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAM 937
            || |..||..||||.:::   .|.:.:|..|..||..||.|.|||.|||||.:..|..:|.||..
Human   622 LS-HSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCR 685

  Fly   938 RGRLLSLLR-----------------AARSATNILPASVP------------GG----------- 962
            .|.|:..|.                 :|...:|.||..:|            ||
Human   686 YGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVD 750

  Fly   963 -------------------RSLAP-----------------------LSPRTLAGFALDIACGME 985
                               ..:||                       ||...|.||:..:|.|||
Human   751 YVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGME 815

  Fly   986 YIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDF 1050
            ::|.:..|||||||||||:....:.||||||:                 |.|:||.:.:..|
Human   816 FLASKNCVHRDLAARNVLICEGKLVKICDFGL-----------------ARDIMRDSNYISK--- 860

  Fly  1051 GSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTET 1115
            ||.:                                         ||::||||||:...::||.:
Human   861 GSTF-----------------------------------------LPLKWMAPESIFNSLYTTLS 884

  Fly  1116 DIWAFGIVLWEIATLGSTPYSQL-TGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRP 1179
            |:|:|||:||||.|||.|||.:| ...:....:.:|.|...|..:..|.|.:|.:||.::..:||
Human   885 DVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRP 949

  Fly  1180 SFAQSRLEITRSL-------HKWVDDDSAASDY 1205
            .|:|..|.:.|.|       ::.||::...||:
Human   950 PFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDH 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	122/414 (29%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	122/412 (30%)
PDGFRB	NP_002600.1	ig	37..114	CDD:278476
		IG	40..110	CDD:214652
		IG_like	222..310	CDD:214653	17/77 (22%)
		Ig1_PDGFR-alphabeta	228..312	CDD:143269	18/79 (23%)
		Ig4_PDGFR-alpha	314..415	CDD:143267	17/106 (16%)
		Ig	425..523	CDD:299845	23/139 (17%)
		PTKc_PDGFR_beta	562..953	CDD:133238	133/517 (26%)
		Pkinase_Tyr	600..953	CDD:285015	122/414 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1019..1106
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910