Protein Alignment Tie and PDGFRL

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_001359002.1
• Gene: PDGFRL / 5157
• HGNCID: 8805
• Length: 375
• Species: Homo sapiens
• Alignment Length: 224
• Identity: 40/224 - (17%)
• Similarity: 62/224 - (27%)
• Gaps: 89/224 - (39%)

  Fly   849 FERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVSLKDEANIMRKLGSH 913
            |:.|.:.:|.....|....|....||  :|.|..       .::.||..:..||||    |.||.
Human   112 FKDSRLSVKQNERYGQLTLVNSTSAD--TGEFSC-------WVQLCSGYICRKDEA----KTGST 163

  Fly   914 QNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFAL 978
            ....|..|......|....:.|         |...|.|.
Human   164 YIFFTEKGELFVPSPSYFDVVY---------LNPDRQAV-------------------------- 193

  Fly   979 DIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNA 1043
             :.|.:..::.:..:||:..|:.:..:          |..|..|.:|
Human   194 -VPCRVTVLSAKVTLHREFPAKEIPAN----------GTDIVYDMKR------------------ 229

  Fly  1044 HKFKFDFGSRYILQHWQHTFGQGQGQGHC 1072
                   |..|:..|.:|     ||..:|
Human   230 -------GFVYLQPHSEH-----QGVVYC 246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	38/219 (17%)
		PTKc	860..1187	CDD:270623	37/213 (17%)
PDGFRL	NP_001359002.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..64
		IG_like	83..145	CDD:214653	9/41 (22%)
		Ig	293..372	CDD:386229

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900