DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and kitb

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001137390.1	Gene:	kitb / 497629	ZFINID:	ZDB-GENE-050916-2	Length:	957	Species:	Danio rerio

Alignment Length:	921	Identity:	197/921 - (21%)
Similarity:	314/921 - (34%)	Gaps:	300/921 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   511 LPTDESTTTTSTTTTTEKPSTTTSTSTTT---------TTPVPSTSKRTTTN-----------AP 555
            |..||::......|.|:.....|..:|.|         ...:.|...|...|           .|
Zfish    69 LKDDEASVILLNITETQHMGNYTCENTETEEKSSIYIYVKDLGSAFVRRMVNDLQVRKGEEITLP 133

  Fly   556 LSTTNTPT------TTTSSTTPSTTT--TSSTSTTVIPTTTKA-------------NSIIEKDKE 599
            ...|:...      |...|..|:..|  |.......|...:||             ..:..::..
Zfish   134 CLVTDPAVSHLSLQTCNGSALPAALTFITHPQGGITIRNVSKAFEGCYFCAGQLDQKPVKSREYN 198

  Fly   600 LIRALGPALTREINIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTDSSPKILRTTVLTSIRSTVH 664
            |:..|.|.....|::....|:|:..:.......:........|...:.|.  ..|.|.|.:|.:.
Zfish   199 LVVRLAPESVPAISLSRNENVILIQDQEFKLSCSAVNINHDFHLRWTIPS--EATALESHKSNIQ 261

  Fly   665 P--RPTSTSTT---------------TSTTTTAPPAVTAPSNEVY----IGI------------- 695
            |  |....|.|               .:.......::.|.:.|||    |.:
Zfish   262 PGSREYQRSITLWIQSVKINDTGSYRCNARNEKGVSMAAVNLEVYERGFINLTEGENRVVEVREG 326

  Fly   696 ------VESSSSASPADISSTVIANERDL-----------NMEMRRMNLVTLVLV---AVGVIPL 740
                  ||.:|...|.|:..|.  |.::|           |.:.|.::.:.||.|   ..|:...
Zfish   327 ESLTLSVEITSYPKPNDVLWTY--NNQELQNTSEHVITLHNQQYRYISELRLVRVHGSEGGIYTF 389

  Fly   741 AAIILY--LVRNFVIRRRAKQSEVFDVCITDQQPIS----------PVKKVDSKY---------- 783
            :|...|  :.::|.:....|     .|.::.:.|:.          ||.|:...|
Zfish   390 SANHKYESVNQSFTVHVICK-----PVIVSQEGPVDGQVRCVASGYPVPKISWYYCEPPHTRCSH 449

  Fly   784 -----QVDDD------------EDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHN 831
                 |.|::            ..||:.:.:.........:...:.|..||..:...|:|...|.
Zfish   450 LLNATQADEEFAVITVSGSEFGRSEVESRLNISKGKFHTLECVASAQGEQAYTLFSISERTVPHK 514

  Fly   832 RY------------------------------------------GNN---DDKTSLASE-FHDFE 850
            .:                                          |||   .|.|.|..: ..:|.
Zfish   515 LFTPLLSGVVSTSVLLSFILVVLLYKYMQKPKYEIHWKVIDSFDGNNYTYIDPTQLPYDPKWEFP 579

  Fly   851 RSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRA---CSAQVSLKDEANIMRKLGS 912
            |..:|...:||.|.||:|..|.|..|......| .||||.::.   .:.:.:|..|..::..:|:
Zfish   580 RERLRFGKILGSGAFGKVVAATAYGLCSADTVT-TVAVKMLKPSAHSTEKEALMSELKVLSYIGN 643

  Fly   913 HQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSA-----------TNILPASVPG----- 961
            |.|:|.|||||....|.::|.||...|.||:.||..|.|           .|:|..:.|.
Zfish   644 HINIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDAFFSSKTGDGYYKNLLSQTQPSIEGTD 708

  Fly   962 -----GRSLAPLSPRT---------------LAGFALDIACGMEYIAGRRIVHRDLAARNVLLDH 1006
                 .||....|.:|               |..|:..:|.||:::..:..:|||||||||||..
Zfish   709 NGYMPMRSYQKRSNQTEWCDDKDDLSLDTEDLLSFSYQVAKGMDFLTSKNCIHRDLAARNVLLTQ 773

  Fly  1007 NGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGH 1071
            ..:.||||||::.|:..:          :|.::|.||.
Zfish   774 GRVAKICDFGLARDITRD----------SNYVLRGNAR--------------------------- 801

  Fly  1072 CSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYS 1136
                                    ||::||:||||...::|.|:|:|::||:||||.:||:|||.
Zfish   802 ------------------------LPVKWMSPESLFACVYTFESDVWSYGILLWEIFSLGNTPYP 842

  Fly  1137 QL-TGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQ--SRLEITRSLHKWVDD 1198
            .: .|....:.:..|.|...|:.:..|.|.:|..||..:|..||.|.:  .|.|:..|
Zfish   843 GIPVGSTFYKMIQDGYRMSEPEFAPSEIYEVMRWCWSADPLKRPPFKKLVERTELLLS------- 900

  Fly  1199 DSAASDYMDVS 1209
            ::...||:::|
Zfish   901 ETTKHDYLNLS 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	107/368 (29%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	107/368 (29%)
kitb	NP_001137390.1	IG_like	121..201	CDD:214653	11/79 (14%)
		Ig	209..305	CDD:299845	14/97 (14%)
		IG	225..305	CDD:214652	11/81 (14%)
		Ig	309..407	CDD:299845	18/99 (18%)
		I-set	319..406	CDD:254352	17/88 (19%)
		PKc_like	547..896	CDD:304357	116/410 (28%)
		Pkinase_Tyr	583..894	CDD:285015	107/372 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900