DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tie and yes1

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001008186.1	Gene:	yes1 / 493548	XenbaseID:	XB-GENE-495082	Length:	537	Species:	Xenopus tropicalis

Alignment Length:	352	Identity:	108/352 - (30%)
Similarity:	153/352 - (43%)	Gaps:	95/352 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   842 LASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIR-ACSAQVSLKDEAN 905
            |:.:..:..|.::||...||:|.||:||       .|.:..|..||:||:: ......:...||.
Frog   259 LSKDAWEIPRESLRLDVKLGQGCFGEVW-------IGTWNGTTKVAIKTLKPGTMMPEAFLQEAQ 316

  Fly   906 IMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSP 970
            ||:|| .|..:|.|. |.|..||..::.||..:|.||..|:........||
Frog   317 IMKKL-RHDKLVPLY-AVVSEEPIYIVTEYMTKGSLLDFLKEGDGKYLKLP-------------- 365

  Fly   971 RTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAA 1035
             .|...|..||.||.||.....:||||.|.|:|:..|.:|||.|||::      |:.::.|..|.
Frog   366 -QLVDMAAQIADGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLA------RLIEDNEYTAR 423

  Fly  1036 NDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRW 1100
            .              |:::                                          ||:|
Frog   424 Q--------------GAKF------------------------------------------PIKW 432

  Fly  1101 MAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPK---ESRHE 1162
            .|||:..|..||.::|:|:|||:|.|:.|.|..||..:..|||:.:|.:|.|...|:   ||.||
Frog   433 TAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHE 497

  Fly  1163 FYNLMSRCWHKEPHMRPSF--AQSRLE 1187
               ||..||.|:|..||:|  .||.||
Frog   498 ---LMKLCWKKDPDERPTFEYIQSFLE 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	102/334 (31%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	102/332 (31%)
yes1	NP_001008186.1	SH3_Yes	88..145	CDD:212940
		SH2_Src_family	148..247	CDD:199827
		PTKc_Yes	258..536	CDD:270654	108/352 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010