DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tie and ROR1

DIOPT Version :10

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_005003.2 Gene:ROR1 / 4919 HGNCID:10256 Length:937 Species:Homo sapiens


Alignment Length:883 Identity:180/883 - (20%)
Similarity:292/883 - (33%) Gaps:322/883 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   491 PLIITVLSA-----------EEETTVGQTEALPTD----ESTTTTSTTTTTEKPSTTTSTSTTTT 540
            |.::.:|:|           |.|.:| ..|.:||.    .|.....:..|.::|....:||...|
Human    11 PPLLALLAALLLAARGAAAQETELSV-SAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQT 74

  Fly   541 TPV--------PSTSKRTTTNAP------------------LSTTNTPTTTTS----STTPSTTT 575
            ..:        |.|.:....:||                  |...|..||.|.    ..|.....
Human    75 AELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEV 139

  Fly   576 TSSTSTTVI-----PTTTKANS-IIEKDKELIRALGPALTREIN--------------------- 613
            .|||....:     ||.:...| ..|:|.......|.|..|.|.                     
Human   140 VSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITA 204

  Fly   614 ----IDDANNL----------------IVFCNNTS-----------DCGVTPRTQTQPSHT-TDS 646
                |..:::|                ..:|:.||           :|.:......|..:. ..|
Human   205 AFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEILENVLCQTEYIFARS 269

  Fly   647 SPKILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEVY-------------IGIVES 698
            :|.||....|.:....  |:|.|...........|.|  .|.|:.:             :.:.:|
Human   270 NPMILMRLKLPNCEDL--PQPESPEAANCIRIGIPMA--DPINKNHKCYNSTGVDYRGTVSVTKS 330

  Fly   699 SSSASP----------------------------------------------ADISSTVIANERD 717
            .....|                                              :|:......:.:|
Human   331 GRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKD 395

  Fly   718 LNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSK 782
             :.|..:|.::.:::.:| .||||..:|:                |.:|:.              
Human   396 -SKEKNKMEILYILVPSV-AIPLAIALLF----------------FFICVC-------------- 428

  Fly   783 YQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSL----- 842
                                       :|:|...:.|:    ||...|.| |.|.:.:.|     
Human   429 ---------------------------RNNQKSSSAPV----QRQPKHVR-GQNVEMSMLNAYKP 461

  Fly   843 ASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGH-----FGATRIVAVKTIRACS---AQVS 899
            .|:..:...|.:|....|||..||:::|       ||     ....::||:||::..:   ....
Human   462 KSKAKELPLSAVRFMEELGECAFGKIYK-------GHLYLPGMDHAQLVAIKTLKDYNNPQQWTE 519

  Fly   900 LKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRS 964
            .:.||::|.:| .|.|:|.||||..:.:|..::.||..:|.|...|......:::..:|...|..
Human   520 FQQEASLMAEL-HHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTV 583

  Fly   965 LAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKE 1029
            .:.|........|:.||.||||::....||:||||||:|:......||.|.|:|.::.:....:.
Human   584 KSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRV 648

  Fly  1030 QEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRH 1094
            |.|:                                                             
Human   649 QSKS------------------------------------------------------------- 652

  Fly  1095 ALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLP--K 1157
            .||||||.||::.|..|::::|||:||:|||||.:.|..||...:.:|||..|.:  |..||  :
Human   653 LLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRK--RQLLPCSE 715

  Fly  1158 ESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKW 1195
            :.....|:||:.||::.|..||.|.    :|...|..|
Human   716 DCPPRMYSLMTECWNEIPSRRPRFK----DIHVRLRSW 749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 95/338 (28%)
ROR1NP_005003.2 IG_like 66..148 CDD:214653 16/81 (20%)
Ig strand B 75..79 CDD:409570 0/3 (0%)
Ig strand C 88..92 CDD:409570 1/3 (33%)
Ig strand E 114..118 CDD:409570 1/3 (33%)
Ig strand F 128..133 CDD:409570 0/4 (0%)
Ig strand G 141..144 CDD:409570 2/2 (100%)
CRD_TK_ROR1 166..307 CDD:143576 22/144 (15%)
KR 311..393 CDD:214527 3/81 (4%)
PTKc_Ror1 467..749 CDD:270672 98/356 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 753..779
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 833..890
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.