Protein Alignment Tie and drl

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Alignment Length: 663
• Identity: 143/663 - (21%)
• Similarity: 230/663 - (34%)
• Gaps: 267/663 - (40%)

  Fly   664 HPRPTSTSTTTSTTTTAPPAV-------TAPSNEVYIGIVESSSSASPADISSTVIANERDLNME 721
            ||.|.|.:..||.|...|..:       ..|......||....|....|:::.|:       |:|
  Fly    77 HPLPYSINIATSDTEVLPRPILNISRIGDVPVEPQTWGIALKCSGTRNAEVTVTI-------NVE 134

  Fly   722 M---RRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKY 783
            :   |..|..|                    |.:.:|:       .:|:.::|        ||.:
  Fly   135 VILDRATNNNT--------------------NLIFKRK-------KICLREEQ--------DSAH 164

  Fly   784 QVDDDEDEVDHQHHQHMQHHQN-HQNHQNHQH-----HQA----------MPM----SQASQRD- 827
            : :.|:|::|........|..: |...:|.:|     |||          .|:    |..|:||
  Fly   165 E-EYDDDDLDLLQTARKGHGGDIHYVDRNDEHVVANGHQAPEKQRPVVTESPVGRGNSGGSKRDF 228

  Fly   828 -------------------------------------------ANHNRYGNNDDKTS-------- 841
                                                       ..|...|.:..|||
  Fly   229 DPMLRENLVPPASGLVTLIVGGILALVLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTI 293

  Fly   842 ---------------------LASEFHDFE----------------RSNIRLKSLLGEGNFGQVW 869
                                 |...|.::|                :..:||..|:.|||||:::
  Fly   294 SSTAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIY 358

  Fly   870 KAEADDLSGHFGATRIVAVKTI--RACSAQVSLKDEANIMRKLGSHQNVVTLLGACVE--SEPHM 930
            :       |.:...:.|.|||:  .|...||:|..:.::|....||.||:::||..:|  :.|.:
  Fly   359 R-------GTYNDCQEVLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFV 416

  Fly   931 LIMEYAMRG---RLLSLLR---AARSATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAG 989
            |   ||..|   .|.|.|:   .|||.|.|               ...|.|..|  |..||::..
  Fly   417 L---YAATGSVRNLKSFLQDPSYARSVTTI---------------QTVLMGSQL--AMAMEHLHN 461

  Fly   990 RRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRY 1054
            ..::|:|:||||.::|.....|:.|..:|.||                        |..|:.|
  Fly   462 HGVIHKDIAARNCVIDDQLRVKLTDSALSRDL------------------------FPGDYNS-- 500

  Fly  1055 ILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWA 1119
                    .|.|:.:                           ||:|::.|:||...:...:|:|:
  Fly   501 --------LGDGEYR---------------------------PIKWLSLEALQKSHYNEGSDVWS 530

  Fly  1120 FGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQS 1184
            ||:::||:.|||..||:::...|:...:..|.|...|.....|.:.:|:.||...|..||||:|.
  Fly   531 FGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQL 595

  Fly  1185 RL-------EITR 1190
            ::       :|||
  Fly   596 QICLSEFHTQITR 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	91/338 (27%)
		PTKc	860..1187	CDD:270623	89/343 (26%)
drl	NP_001260566.1	WIF	21..157	CDD:128745	22/113 (19%)
		PTK_Ryk	336..606	CDD:270639	92/357 (26%)
		Pkinase_Tyr	343..599	CDD:285015	92/343 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455326
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030