DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and InR

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001138093.1	Gene:	InR / 42549	FlyBaseID:	FBgn0283499	Length:	2144	Species:	Drosophila melanogaster

Alignment Length:	394	Identity:	111/394 - (28%)
Similarity:	179/394 - (45%)	Gaps:	92/394 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   848 DFE--RSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSA---QVSLKDEANIM 907
            |:|  |.||...:.||:|:||.|::........: |..|..|:||:...:.   :.:...||::|
  Fly  1363 DWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPN-GVDRECAIKTVNENATDRERTNFLSEASVM 1426

  Fly   908 RKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAAR-------SATNILPASVPGGRSL 965
            ::..:: :||.|||.|...:|.:::||...:|.|.|.|||.|       ..|.:....|.|  ::
  Fly  1427 KEFDTY-HVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTG--NV 1488

  Fly   966 APLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDL-DAERMRKE 1029
            .|.:...:...|::||.||.|:|.::.|||||||||.::..:...||.||||:.|: :.:..||
  Fly  1489 QPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRK- 1552

  Fly  1030 QEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRH 1094
                                                                         |.:.
  Fly  1553 -------------------------------------------------------------GTKG 1556

  Fly  1095 ALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKES 1159
            .||:|||.||||:..::::.:|:::||:||||:|||.:.||..|:..:|:|.|..|...:.|:..
  Fly  1557 LLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENC 1621

  Fly  1160 RHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVSGFSEDLEHGVVYFNH 1224
            ....:.||.||||.....||||    |:|.    .:::.....|.:.:||.:     |......|
  Fly  1622 PDFLHKLMQRCWHHRSSARPSF----LDII----AYLEPQCPNSQFKEVSFY-----HSEAGLQH 1673

  Fly  1225 RISE 1228
            |..|
  Fly  1674 REKE 1677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	98/339 (29%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	97/337 (29%)
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382
		Furin-like	512..645	CDD:279142
		FU	545..592	CDD:238021
		Recep_L_domain	663..781	CDD:279382
		FN3	1224..1302	CDD:238020
		PTKc_InsR_like	1364..1652	CDD:173625	103/361 (29%)
		Pkinase_Tyr	1371..1650	CDD:285015	100/352 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455320
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940