DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and htl

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	770	Identity:	180/770 - (23%)
Similarity:	279/770 - (36%)	Gaps:	235/770 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   549 RTTTNAPLSTTNTPTTTTSST-TPSTTTTSSTSTTVIPTTTKANSIIEKDKEL----IRALGPAL 608
            |:....|..|.|...::|||. ..........:...:|....:.......|::    .|..|..|
  Fly    57 RSQNKTPAITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLL 121

  Fly   609 TREINI--DDANNLIVFCNNT------------------------SDCG------------VTPR 635
            |...:.  :...|:..:.|.|                        .|||            :...
  Fly   122 TLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHD 186

  Fly   636 TQTQPSHTTDSSPKI----LRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEVYIGIV 696
            ||...|...:..|.:    |..|::.:...::|.:..|..|:.......|          ..|:.
  Fly   187 TQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVP----------CHGMT 241

  Fly   697 ESSSSASPADISSTVIANERD----LNMEMRRMNLVTLVL------------------------- 732
            ..|::.|       :||.::|    :|:.|.:....|.|.
  Fly   242 NCSNNRS-------IIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAG 299

  Fly   733 VAVGVIPLAA----------IILYLVRNFVIR--RRAKQSEVFDVCITDQQPISPVKKVDSKYQV 785
            ||.|.:...:          |.:::...||..  |:.|..:|.      :|.|..|.:...|..:
  Fly   300 VASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVL------KQRIETVHQWTKKVII 358

  Fly   786 DDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGN-----NDDKTSLASE 845
            ...|...|               .........||:.:..::.....:.||     |:.:..|.|.
  Fly   359 FKPEGGGD---------------SSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSN 408

  Fly   846 FHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQ---VSLKDEANIM 907
            : :..||::.|.:.||||.||:|..||.::        .|||||.::.....   .||..|..:|
  Fly   409 W-ELPRSHLVLGATLGEGAFGRVVMAEVNN--------AIVAVKMVKEGHTDDDIASLVREMEVM 464

  Fly   908 RKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGR------SLA 966
            :.:|.|.|::.|||.|.::.|..:|:|||..|.|...|...|          |.||      |..
  Fly   465 KIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNR----------PFGRDQDRDSSQP 519

  Fly   967 PLSP-------RTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAE 1024
            |.||       :.|..||..||.||:|:|.||.:||||||||||:..:.:.||.|||::.|:.
  Fly   520 PPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQ-- 582

  Fly  1025 RMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDT 1089
                      :.|..|.|                                              |
  Fly   583 ----------STDYYRKN----------------------------------------------T 591

  Fly  1090 IGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPY-SQLTGREVIRRVPQGLRP 1153
            .|:   |||:||||||||...:.:::|:|::||:||||.|.|..|| :.::..|:...:..|.|.
  Fly   592 NGR---LPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRM 653

  Fly  1154 DLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDV 1208
            :.|.:.....|.||.:|||.....||.|.    ||...:.|.:   ....||:||
  Fly   654 EKPAKCSMNIYILMRQCWHFNADDRPPFT----EIVEYMDKLL---QTKEDYLDV 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	110/345 (32%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	109/343 (32%)
htl	NP_524394.2	Ig	112..191	CDD:299845	12/78 (15%)
		IG_like	113..191	CDD:214653	12/77 (16%)
		IG_like	205..289	CDD:214653	16/100 (16%)
		PKc_like	404..692	CDD:304357	117/371 (32%)
		STYKc	416..688	CDD:214568	112/354 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455231
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840