Protein Alignment Tie and Csk

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_001262476.1
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 1227
• Identity: 236/1227 - (19%)
• Similarity: 412/1227 - (33%)
• Gaps: 398/1227 - (32%)

  Fly   155 TYRPSGANRPSIAPLNSAQDRERKLMNVLAARRTALHRGGFRTRIGTTGRTAISPSAAVESTSKA 219
            |..||||:    |.::|:.:|..|..:..|                       |||.:...:..:
  Fly    23 TPSPSGAD----ATVSSSLERVLKPASASA-----------------------SPSNSNNESDNS 60

  Fly   220 PSDPRSVCIRNCTKNFTRRTTASCMRQCANFTRMAMPSNGNSSVVLKGSASLKAAAPAG----DR 280
            .:...|....:.:|...|....|.....|..||.............|.|....|||...    .|
  Fly    61 QTSSGSQTASSASKRSNRSVGRSHRGSIAQDTRRRYYFGSKDIYWCKQSREAAAAATLSGSGLTR 125

  Fly   281 DTNEILFSDESSH----GLFVVAKEQNGTLNHIADGTKPAVMGKGIPSKTNSMEDDVEEEEDELK 341
            ..:.:...:.|:|    |..|:::.:.          ||.::...:.:
  Fly   126 SASSVTHKEASTHATHTGGQVISRARR----------KPILLCSSLSA----------------- 163

  Fly   342 PYVYFGAKLPPIR----------PGGLTIKAAEGDDDHPRVLEVSVAQSTTPTITTTSTTPAPVS 396
                  |..||.|          ||                     ...:|||.||||.|.|...
  Fly   164 ------AYAPPRRREFYFCDKYAPG---------------------PARSTPTTTTTSATSAKHE 201

  Fly   397 STRPTAS--------------TRRPLTPVERSRSKYKYHMRER----GLVPTAAPPPAA------ 437
            |:.|..:              ..:..|.:::::.::..:.|||    |...:.:.||.|
  Fly   202 SSPPIDARLLNFLRCAHRKFQASKAKTELQQTKDRFLGNSRERTSKNGQQTSRSLPPIASSEEWF 266

  Fly   438 PPAPPVSRTRYVGSGRPTAGLSDSIQDLKQTESEVAKPVVRRVVQKVSPSSSTPLIITV-----L 497
            .......:|.:..|.:|..         |..|:...|..:.|   |.|....   :|||     |
  Fly   267 DEEAQARKTSHEKSQKPKP---------KPEENHKEKEAISR---KASGEGD---LITVEIKQGL 316

  Fly   498 SAEEETTVGQTEALPTDESTTTTSTTTTT------EKPSTT----TSTSTTTTTP--VPSTSKRT 550
            ..::..|....:|:.:..:.|....||..      .:||.|    .:|.:|...|  :.:|..:.
  Fly   317 LRKQTATTTTGQAMNSHATATQNGQTTVVGHHRGFSQPSVTVAAAAATGSTAGDPWFLQTTGHQM 381

  Fly   551 TTNAPLSTTNTPT--------TTTSSTTPSTTT---------TSSTSTTVIPTTTKANSIIEKDK 598
            ...|||.....|.        ..:|.|.|.:..         .|.:...::|.:...:....::.
  Fly   382 PPTAPLRHNKRPAPQPNAVLGAGSSGTAPGSAVGAVLLHQQQLSQSQPHIVPPSIPPHHHHHREN 446

  Fly   599 EL--IRA-LGPALTREINIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTDSSPKILRTTVLTSIR 660
            .:  |:| ...||....:..:::|||...:|.|.  .:|....|...||:...:..:.....||.
  Fly   447 NVHPIQAGAAAALHLSSHALNSHNLISSASNHSP--KSPSQTQQQQQTTNQQQQQQQQQASHSIL 509

  Fly   661 STVHPRPT------STSTTTSTTTTAPPAVTAPSNEVYIGIVESSSSASPADISSTVIANERDLN 719
            ||..|.||      :.|.:.:.|..|..||.....:.::.::.:........:||::.|.:..::
  Fly   510 STFAPAPTVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLANCPPGGAGLMSSSLNAAQMGMH 574

  Fly   720 MEMRRMNLVTLVL------------------------VAVGV----------------------- 737
            ...|.:...:|.|                        ..|||
  Fly   575 GAERALPPKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAG 639

  Fly   738 -------------------------------------IPLAAIILY---LVRN------------ 750
                                                 :.|.|:..:   :.|:
  Fly   640 SGVNASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLLQPREDG 704

  Fly   751 -FVIRRRAKQSEVFDVCITDQQPIS--PVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNH 812
             |::|........:.:|:..|..:.  .||.:::|..:||  :|......|.:.|::...:....
  Fly   705 LFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDD--EEYFENLGQLVAHYEADADGLCT 767

  Fly   813 QHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHD----FERSNIRLKSLLGEGNFGQVWKAEA 873
            |..:.:|.....:...|             :.:|.|    ...:.::|:..:|:|.||.|.
  Fly   768 QLIKCLPKLGKQEFCIN-------------SKDFVDKGWVIPEAELQLRESIGKGEFGDVM---- 815

  Fly   874 DDLSGHFGATR--IVAVKTIRACSAQVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYA 936
                  .|..|  .||||.::...|......||::|..| .|.|:|..:|....|:...|:.||.
  Fly   816 ------LGILRNEKVAVKMLKDEGAVQKFLAEASVMTTL-EHDNLVKFIGLVFTSKHLYLVTEYM 873

  Fly   937 MRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARN 1001
            .:|.|:..||:               |....::.:....||.|.|.||||:..:::|||||||||
  Fly   874 SKGSLVDYLRS---------------RGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARN 923

  Fly  1002 VLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQG 1066
            ||:..:.:.|:.|||::        |:|               .:..|.|.
  Fly   924 VLISEDCVAKVSDFGLA--------REE---------------CYNLDVGK-------------- 951

  Fly  1067 QGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLG 1131
                                         |||:|.|||:|:...|:.::|:|:|||:||||.:.|
  Fly   952 -----------------------------LPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFG 987

  Fly  1132 STPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEI 1188
            ..||.::...:|::.|..|.:.:.|:....|.|.:|.:.|...|..||:||:.::::
  Fly   988 RVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKL 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	90/330 (27%)
		PTKc	860..1187	CDD:270623	90/328 (27%)
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	16/98 (16%)
		PTKc_Csk_like	793..1047	CDD:270635	91/344 (26%)
		STYKc	800..1044	CDD:214568	91/335 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.010