DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and yes1

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001013288.2	Gene:	yes1 / 407620	ZFINID:	ZDB-GENE-050126-1	Length:	546	Species:	Danio rerio

Alignment Length:	640	Identity:	154/640 - (24%)
Similarity:	240/640 - (37%)	Gaps:	199/640 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   629 DCGVTPRTQTQPSHTTDSSPKIL-----------------------RTTVLTSI---RSTVHPRP 667
            |.|.|.:.:..|::.|..|...|                       |::.||..   .|.:.|..
Zfish     9 DKGPTQKYRPDPTNPTPGSHMGLYGPDPTQMGQSPALKGPTNNYNSRSSGLTPFGGSSSVITPFG 73

  Fly   668 TSTSTTTSTTTTAP-PAVTAPSNEVYIGIVESSSSASPADISST------VIANERDLNMEMRRM 725
            .::|:.::.....| |.|.......::.:.:..:..|. |:|.:      :|.|......|.|.:
Zfish    74 GASSSFSTVAVNNPFPGVVTGGVTFFVALYDYEARTSD-DLSFSKGDRFQIINNTEGDWWEARSI 137

  Fly   726 NLVTLVLVAVGVIPL-----------------------AAIILYLVRN----FVIRRRAKQSEVF 763
            |     ....|.||.                       |..:|.|..|    |::|........:
Zfish   138 N-----TGQKGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLLPGNQRGTFLVRESETTKGAY 197

  Fly   764 DVCITDQQPIS-------PVKKVDS-------KYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQH 814
            .:.|.|...:.       .::|:||       :.|.|..:..|        :|:..|.:...::.
Zfish   198 SLSIRDWDEMKGDNVKHYKIRKLDSGGYYITTRAQFDTLQKLV--------KHYTEHADGLCYRL 254

  Fly   815 HQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGH 879
            ....|..:...:              .||.:..:..|.::||:..||:|.||:||       .|.
Zfish   255 TTVCPTVKPQTQ--------------GLAKDAWEIPRESLRLELKLGQGCFGEVW-------MGT 298

  Fly   880 FGATRIVAVKTIR--ACSAQVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLL 942
            :..|..||:||::  ..|.:..|: ||.||:|| .|..:|.|. |.|..||..::.||..:|.||
Zfish   299 WNGTTKVAIKTLKPGTMSPEAFLQ-EAQIMKKL-RHDKLVPLY-AVVSEEPIYIVTEYMGKGSLL 360

  Fly   943 SLLRAARSATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHN 1007
            ..|:........||               .|...|..||.||.:|.....:||||.|.|:|:..|
Zfish   361 DFLKEGEGKYLKLP---------------QLVDMAAQIADGMAFIERMNYIHRDLRAANILVGDN 410

  Fly  1008 GMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHC 1072
            .:|||.|||::      |:.::.|..|..              |:::
Zfish   411 LVCKIADFGLA------RLIEDNEYTARQ--------------GAKF------------------ 437

  Fly  1073 SKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQ 1137
                                    ||:|.|||:..|..||.::|:|:|||:|.|:.|.|..||..
Zfish   438 ------------------------PIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPG 478

  Fly  1138 LTGREVIRRVPQGLRPDLPK---ESRHEFYNLMSRCWHKEPHMRPSF--AQSRLE 1187
            :..|||:.:|.:|.|...|:   ||.||   :|..||.|||..||:|  .||.||
Zfish   479 MVNREVLEQVERGYRMPCPQGCPESLHE---MMRLCWKKEPDERPTFEYIQSFLE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	103/335 (31%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	103/333 (31%)
yes1	NP_001013288.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		8/48 (17%)
		SH3_Yes	97..154	CDD:212940	11/62 (18%)
		SH2_Src_family	157..256	CDD:199827	16/106 (15%)
		PTKc_Yes	267..545	CDD:270654	110/354 (31%)
		Pkinase_Tyr	280..529	CDD:285015	105/338 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010