DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tie and pdgfra

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_571534.1	Gene:	pdgfra / 386856	ZFINID:	ZDB-GENE-990415-208	Length:	1059	Species:	Danio rerio

Alignment Length:	873	Identity:	194/873 - (22%)
Similarity:	298/873 - (34%)	Gaps:	330/873 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   544 PSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVI---PTTTKANSIIEKDKELIR--- 602
            |.|.|....|..:..    |.|.::.:|..:...:.|.|.|   .:.||..:|...|.|.:.
Zfish   233 PKTVKENKLNLEIYY----TLTVTNASPKDSGIYACSITDIMSNESQTKELTITVYDHEFVHINP 293

  Fly   603 ALGPALTR------EINIDDAN---NLIVFCNNTSDCGVTPRTQTQPSHTTDSSPKILR------ 652
            .:||..|.      |..:|..:   ..:.:..::|..|         ..|.:.|..:|:
Zfish   294 LIGPVETARLDEVPEFKVDIESFPAPKVTWLKDSSVLG---------DDTAEISTTLLKIGETSY 349

  Fly   653 TTVLTSIRS--------TVHPRPTSTSTTTS--TTTTAPPAVT---------------------A 686
            ..||..||:        ||.....|.||:.|  .....||.:.                     :
Zfish   350 QGVLNLIRAKAEDSGNYTVKAEIGSISTSYSFYLQVKVPPVIVDLIDVHHGSAAGQEVVCTAGGS 414

  Fly   687 PSNEVYIGIVES-------SSSASPADISSTVIANERDLNME----------------------- 721
            |..||...|.::       ||...|..|:||.|..|..:|::
Zfish   415 PFPEVDWDICKNLKHCANDSSQWMPLPINSTDITVELQMNVDNHIESHIIFHHLEGTVAVRCLAR 479

  Fly   722 ------MRRMNLVT------LVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPIS 774
                  .|.:.|::      |.:.|..::.|..:|:.|:...:|   .||...:::.....:.:|
Zfish   480 NDMGVVSREVKLMSSGPHSELTVAAAVLVLLVIVIISLIVLVII---WKQKPRYEIRWRVIESVS 541

  Fly   775 PVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDK 839
            |                                  ..|::....||.....     :|:
Zfish   542 P----------------------------------DGHEYIYVDPMQLPYD-----SRW------ 561

  Fly   840 TSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRI-----VAVKTIR---ACSA 896
                    :|.|..:.|..:||.|.||:|.:..|      :|.:|.     ||||.::   ..|.
Zfish   562 --------EFPRDGLVLGRVLGSGAFGKVVEGTA------YGLSRSQPVMKVAVKMLKPTARSSE 612

  Fly   897 QVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSA---------- 951
            :.:|..|..||..||.|.|:|.|||||.:|.|..:|.||...|.|::.|...|..
Zfish   613 KQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDGFLSRHTEKGK 677

  Fly   952 -----TNILPA------------------------------------------------------ 957
                 ..|.||
Zfish   678 KDLDIFGINPADESSRSYVILSLEGKGDYMDMKQADTMQYVPMLEMNEASKYSPIQRSDYDHPPS 742

  Fly   958 ---------SVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKIC 1013
                     |:....|...|:...|..|...:|.|||::|.:..||||||||||||....:.|||
Zfish   743 HRQFNDEAESLLSDDSAEGLTTMDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLSQGKIVKIC 807

  Fly  1014 DFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPH 1078
            |||:                 |.|:|..|.:..|   ||.:
Zfish   808 DFGL-----------------ARDIMHDNNYVSK---GSTF------------------------ 828

  Fly  1079 GEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPY-SQLTGRE 1142
                             ||::||||||:..:::||.:|:|::||:||||.:||.||| ..:....
Zfish   829 -----------------LPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMVVDSS 876

  Fly  1143 VIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSL--------HKWVDDD 1199
            ...::..|.|...|:.:..:.|.||.:||:.||..|||| .|..:...||        ::.|:.|
Zfish   877 FYNKIKSGYRMTKPEHASSDVYELMMKCWNSEPEKRPSF-HSLSDTVASLLPSGFKRCYERVNHD 940

  Fly  1200 SAASDYMDVSGF----SEDLEHGVVYFN 1223
            ...||:..|:..    ::|...||:|.|
Zfish   941 FLKSDHPAVTRVQCIDNDDAYMGVLYKN 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	113/415 (27%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	113/413 (27%)
pdgfra	NP_571534.1	IG_like	19..94	CDD:214653
		IG_like	199..283	CDD:214653	13/53 (25%)
		Ig	203..285	CDD:299845	13/55 (24%)
		Ig	288..387	CDD:299845	20/107 (19%)
		Ig	389..491	CDD:299845	15/101 (15%)
		PKc_like	530..928	CDD:304357	124/518 (24%)
		Pkinase_Tyr	568..918	CDD:285015	113/417 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	975..1036
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100