Protein Alignment Tie and Lmtk3

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: XP_030098591.1
• Gene: Lmtk3 / 381983
• MGIID: 3039582
• Length: 1451
• Species: Mus musculus
• Alignment Length: 371
• Identity: 102/371 - (27%)
• Similarity: 153/371 - (41%)
• Gaps: 96/371 - (25%)

  Fly   835 NNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVS 899
            ::|..|.|.     ..|.::.....:|.|.||:|...|.  .|.:..|.  |.||.:||.:..:.
Mouse   146 HSDISTPLG-----LSRQHLSYLQEIGSGWFGKVILGEV--FSDYSPAQ--VVVKELRASAGPLE 201

  Fly   900 LK---DEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPG 961
            .:   .||...|.| .|.||:..||.|||:.|.:||||:...|.|...|||.|....:.|
Mouse   202 QRKFISEAQPYRSL-QHPNVLQCLGVCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGMSP----- 260

  Fly   962 GRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERM 1026
              .|.|...|||....|:||.|:.::.....||.|||.||.||..:...:|.|:|:
Mouse   261 --ELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGL--------- 314

  Fly  1027 RKEQEKNAANDLMRHNAH-KFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTI 1090
                            || .:|.|:   |:..
Mouse   315 ----------------AHSNYKEDY---YLTP--------------------------------- 327

  Fly  1091 GKRHALPIRWMAPESL-QYH-MF-----TTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVP 1148
             :|..:|:||.|||.| :.| .|     :.|:::|:.|:.|||:...|:.||..|:..||:..|.
Mouse   328 -ERLWVPLRWAAPELLGELHGSFVLVDQSRESNVWSLGVTLWELFEFGAQPYRHLSDEEVLAFVV 391

  Fly  1149 QG-----LRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEIT 1189
            :.     .||.|.......:|:::..|| :.|..|||.:..:|::|
Mouse   392 RQQHVKLARPRLKLPYADYWYDILQSCW-RPPAQRPSASDLQLQLT 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	96/344 (28%)
Lmtk3	XP_030098591.1	Protein Kinases, catalytic domain	162..437	CDD:473864	98/350 (28%)