DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and KIT

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001372213.1	Gene:	KIT / 3815	HGNCID:	6342	Length:	977	Species:	Homo sapiens

Alignment Length:	1091	Identity:	228/1091 - (20%)
Similarity:	367/1091 - (33%)	Gaps:	361/1091 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 KPYVYFGAKLPP-IRPGGLTIKAAEGDDDHPRVLEVSVAQSTTPTITTTS--------TTPAPVS 396
            :|.|..|...|| |.||...:....||:......:....:.|...:..|:        |..|..:
Human    26 QPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEAT 90

  Fly   397 ST-RPTASTRRPLTPVERSRSKY-------KYHMRERGLV-----PTAAPPPAAPP--------- 439
            :| :.|.:.:..|     |.|.|       |..:.:|.|.     .|....|...|
Human    91 NTGKYTCTNKHGL-----SNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKG 150

  Fly   440 ---APPVSRTRYVGSGRPTAGLSDSIQDLKQ----------TESEVAKPVVRRVVQKVSPSSSTP 491
               .|.....|::..  |.||:  .|:.:|:          .:.|....:..:.:.||.|:....
Human   151 CQGKPLPKDLRFIPD--PKAGI--MIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAV 211

  Fly   492 LIITVLSAE------EETTVGQTEALPTDESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRT 550
            .:::|..|.      ||.||                           |.|....::.|.||.||.
Human   212 PVVSVSKASYLLREGEEFTV---------------------------TCTIKDVSSSVYSTWKRE 249

  Fly   551 TT-------------NAPLSTTNTPTTTTSSTT----------PSTTTTSSTSTTVIPTTTKANS 592
            .:             :...:.....|.|.||..          .:.|..|:..||.:...
Human   250 NSQQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVV----- 309

  Fly   593 IIEKDKELIRALGPALTREINIDDANN--LIV--------------FCNNTSDCGVTPRTQTQPS 641
                ||..|. :.|.:...:.::|..|  |||              :.|.|    .|.:.:..|.
Human   310 ----DKGFIN-IFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRT----FTDKWEDYPK 365

  Fly   642 HTTDSSPKILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEVYIGIVESSSSASPAD 706
            ...:|:.:.:....||.::.|                         ....|..:|  |:|...|.
Human   366 SENESNIRYVSELHLTRLKGT-------------------------EGGTYTFLV--SNSDVNAA 403

  Fly   707 ISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQ 771
            |:..|..|.:...:...|:....|..||.| .|...|..|....  ..:|...|    |...|.|
Human   404 IAFNVYVNTKPEILTYDRLVNGMLQCVAAG-FPEPTIDWYFCPG--TEQRCSAS----VLPVDVQ 461

  Fly   772 PISPVKKVDSKYQVDDDEDEVDHQHHQHMQ----------------HHQNHQNHQNHQH------ 814
            .::.......|..|....|....:|:..::                ..:.:...|.|.|
Human   462 TLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPL 526

  Fly   815 ---------------------HQAMPMSQASQR---DANHNRYGNNDDKTSLASEFHDFERSNIR 855
                                 :...||.:...:   :.|.|.|...|..........:|.|:.:.
Human   527 LIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLS 591

  Fly   856 LKSLLGEGNFGQVWKAEADDLSGHFG-----ATRIVAVKTIRACSAQV----SLKDEANIMRKLG 911
            ....||.|.||:|.:|.|      :|     |...||||.::. ||.:    :|..|..::..||
Human   592 FGKTLGAGAFGKVVEATA------YGLIKSDAAMTVAVKMLKP-SAHLTEREALMSELKVLSYLG 649

  Fly   912 SHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAAR--------------------------- 949
            :|.|:|.|||||....|.::|.||...|.||:.||..|
Human   650 NHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESS 714

  Fly   950 --SATN-----------ILPASVPGGRSL-------------------APLSPRTLAGFALDIAC 982
              .:||           ::|......||:                   ..|....|..|:..:|.
Human   715 CSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAK 779

  Fly   983 GMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFK 1047
            ||.::|.:..:||||||||:||.|..:.||||||::.|:          ||.:|.:::.||.
Human   780 GMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI----------KNDSNYVVKGNAR--- 831

  Fly  1048 FDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFT 1112
                                                            ||::||||||:...::|
Human   832 ------------------------------------------------LPVKWMAPESIFNCVYT 848

  Fly  1113 TETDIWAFGIVLWEIATLGSTPYSQL-TGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPH 1176
            .|:|:|::||.|||:.:|||:||..: ...:..:.:.:|.|...|:.:..|.|::|..||..:|.
Human   849 FESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPL 913

  Fly  1177 MRPSFAQSRLEITRSLHKWVDDDSAASDYMDVSGFSEDLEHGVVYFNHRIS 1227
            .||:|.|    |.:.:.|.: .:|....|.:::..|.:.:..||..:.||:
Human   914 KRPTFKQ----IVQLIEKQI-SESTNHIYSNLANCSPNRQKPVVDHSVRIN 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	107/397 (27%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	108/395 (27%)
KIT	NP_001372213.1	Ig strand A	212..215	CDD:409353	0/2 (0%)
		ig	216..306	CDD:395002	21/116 (18%)
		Ig strand B	229..239	CDD:409353	4/36 (11%)
		Ig strand C'	250..252	CDD:409353	0/1 (0%)
		Ig strand D	260..263	CDD:409353	0/2 (0%)
		Ig strand E	267..280	CDD:409353	2/12 (17%)
		Ig strand F	287..294	CDD:409353	0/6 (0%)
		Ig strand G	300..308	CDD:409353	2/7 (29%)
		IgI_4_SCFR	312..412	CDD:409446	22/131 (17%)
		Ig strand B	332..336	CDD:409446	1/3 (33%)
		Ig strand C	346..350	CDD:409446	0/3 (0%)
		Ig strand E	376..380	CDD:409446	0/3 (0%)
		Ig strand F	390..395	CDD:409446	1/4 (25%)
		Ig strand G	403..406	CDD:409446	1/2 (50%)
		Ig	427..503	CDD:409353	16/82 (20%)
		Ig strand C	438..442	CDD:409353	1/3 (33%)
		Ig strand E	471..479	CDD:409353	2/7 (29%)
		Ig strand F	489..494	CDD:409353	0/4 (0%)
		PTKc_Kit	554..929	CDD:270682	116/446 (26%)
		Important for interaction with phosphotyrosine-binding proteins	569..571		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810