DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tie and KDR

DIOPT Version :9

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_002244.1 Gene:KDR / 3791 HGNCID:6307 Length:1356 Species:Homo sapiens


Alignment Length:1105 Identity:243/1105 - (21%)
Similarity:388/1105 - (35%) Gaps:399/1105 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   286 LFSDESSHGLFVVAKEQNGTLNHIADGTKPAV-MGKGIPSKTNSMEDDVEEEEDELK--PYVYFG 347
            |::..:|.||..   ::|.|...:.:  ||.| .|.|       ||..||....|..  |..|.|
Human   304 LYTCAASSGLMT---KKNSTFVRVHE--KPFVAFGSG-------MESLVEATVGERVRIPAKYLG 356

  Fly   348 AKLPPIR--PGGL------TIKAAEGDDDHP-RVLEVSVAQSTTPTITTTSTTPAPVSSTR---- 399
            ...|.|:  ..|:      ||||.     |. .::|||...:...|:..|:    |:|..:    
Human   357 YPPPEIKWYKNGIPLESNHTIKAG-----HVLTIMEVSERDTGNYTVILTN----PISKEKQSHV 412

  Fly   400 --------PTASTRRPLTPVERSRSKYKYHMRERGLVPT------AAPPP-------------AA 437
                    |....:..::||:    .|:|     |...|      |.|||             |.
Human   413 VSLVVYVPPQIGEKSLISPVD----SYQY-----GTTQTLTCTVYAIPPPHHIHWYWQLEEECAN 468

  Fly   438 PPAPPVSRTR------------YVGSGRPTAGLSDSIQDLKQTESEVA------KPVVRRVVQKV 484
            .|:..||.|.            :.|..:           ::..:::.|      |.|...|:|..
Human   469 EPSQAVSVTNPYPCEEWRSVEDFQGGNK-----------IEVNKNQFALIEGKNKTVSTLVIQAA 522

  Fly   485 SPSSSTPLIITVLSAEEETTVGQTEALPTDESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKR 549
            :.|:       :...|....||:.|.:.:...|.....|...:...|...:.:...|...||.:.
Human   523 NVSA-------LYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFEN 580

  Fly   550 TT------TNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPAL 608
            .|      ...|:.....||....    :..|....:.|:...:|....|:|             
Human   581 LTWYKLGPQPLPIHVGELPTPVCK----NLDTLWKLNATMFSNSTNDILIME------------- 628

  Fly   609 TREINIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTDSSPKILRTTVLTSIRSTV----HPRPTS 669
            .:..::.|..:.:....:         .:|:..|..     :.:.|||..:..|:    ..:.||
Human   629 LKNASLQDQGDYVCLAQD---------RKTKKRHCV-----VRQLTVLERVAPTITGNLENQTTS 679

  Fly   670 TSTTTSTTTTA----PPAVT-APSNEVYIGIVESSSSASPADISSTVIANERDLNMEMRRM---- 725
            ...:...:.||    ||.:. ...||.   :||.|.          ::..:.:.|:.:||:    
Human   680 IGESIEVSCTASGNPPPQIMWFKDNET---LVEDSG----------IVLKDGNRNLTIRRVRKED 731

  Fly   726 ------------------------------NLVTLVLVAVGVIPLAAIILYLVRNFVIR--RRAK 758
                                          ||..::||...||   |:..:|:...::|  :||.
Human   732 EGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVI---AMFFWLLLVIILRTVKRAN 793

  Fly   759 QSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQA 823
            ..|              :|.......:|.||..:|                   :|.:.:|..  
Human   794 GGE--------------LKTGYLSIVMDPDELPLD-------------------EHCERLPYD-- 823

  Fly   824 SQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFG----AT- 883
                               ||:: :|.|..::|...||.|.||||.:|:|      ||    || 
Human   824 -------------------ASKW-EFPRDRLKLGKPLGRGAFGQVIEADA------FGIDKTATC 862

  Fly   884 RIVAVKTIR---ACSAQVSLKDEANIMRKLGSHQNVVTLLGACVE-SEPHMLIMEYAMRGRLLSL 944
            |.||||.::   ..|...:|..|..|:..:|.|.|||.|||||.: ..|.|:|:|:...|.|.:.
Human   863 RTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTY 927

  Fly   945 LRAARSATNILPASVPGGR-------------------------------------SL------- 965
            ||:.|:  ..:|....|.|                                     ||       
Human   928 LRSKRN--EFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEE 990

  Fly   966 AP-------LSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDL-- 1021
            ||       |:...|..::..:|.|||::|.|:.:||||||||:||....:.||||||::.|:  
Human   991 APEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYK 1055

  Fly  1022 DAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHG 1086
            |.:.:||                                                  |:.:    
Human  1056 DPDYVRK--------------------------------------------------GDAR---- 1066

  Fly  1087 HDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQL-TGREVIRRVPQG 1150
                     ||::|||||::...::|.::|:|:||::||||.:||::||..: ...|..||:.:|
Human  1067 ---------LPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEG 1122

  Fly  1151 LRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVSGFSEDL 1215
            .|...|..:..|.|..|..|||.||..||:|::....:...|......|  ..||: |...||.|
Human  1123 TRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQD--GKDYI-VLPISETL 1184

  Fly  1216  1215
            Human  1185  1184

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 115/391 (29%)
PTKc 860..1187 CDD:270623 114/389 (29%)
KDRNP_002244.1 Ig 41..109 CDD:299845
IG_like 231..324 CDD:214653 6/22 (27%)
Ig1_VEGFR 239..326 CDD:143270 6/24 (25%)
IG_like 340..417 CDD:214653 21/85 (25%)
Ig2_VEGFR-2 348..417 CDD:143272 18/77 (23%)
Ig_2 551..661 CDD:290606 17/140 (12%)
IG 565..661 CDD:214652 15/126 (12%)
I-set 667..754 CDD:254352 15/99 (15%)
IGc2 680..744 CDD:197706 12/76 (16%)
PTKc_VEGFR2 826..1167 CDD:270681 118/412 (29%)
Pkinase_Tyr 834..1160 CDD:285015 115/396 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1318
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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