DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tie and Egfr

DIOPT Version :9

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster


Alignment Length:527 Identity:113/527 - (21%)
Similarity:201/527 - (38%) Gaps:174/527 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   671 STTTSTTTTAPPAVTAPSNEVYIGIVESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAV 735
            ::|....|:..|......|..|..|....:::.|.  ||.:.|| .|:||          :.:..
  Fly   823 NSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPR--SSKITAN-LDVNM----------IFIIT 874

  Fly   736 GVIPLAAIILYLVRNFVIRRRAK-QSEVFDVCIT-----DQQPISPVKKVDSKYQVDDDEDEVDH 794
            |.:.:..|.:..|..::.|::.| :.|...:.:.     |.:|:.|                   
  Fly   875 GAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRP------------------- 920

  Fly   795 QHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSL 859
                                                :..|.|..|..:..:      :.:|...:
  Fly   921 ------------------------------------SNIGANLCKLRIVKD------AELRKGGV 943

  Fly   860 LGEGNFGQ----VWKAEADDLSGHFGATRI-VAVKTIRACSAQVSLKD---EANIMRKLGSHQNV 916
            ||.|.||:    ||..|.:::       :| ||:|.:...:...|.::   ||.||..: .|.|:
  Fly   944 LGMGAFGRVYKGVWVPEGENV-------KIPVAIKELLKSTGAESSEEFLREAYIMASV-EHVNL 1000

  Fly   917 VTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFALDIA 981
            :.||..|:.|: .|||.:....|.||..:|..|.                .:..:.|..::..||
  Fly  1001 LKLLAVCMSSQ-MMLITQLMPLGCLLDYVRNNRD----------------KIGSKALLNWSTQIA 1048

  Fly   982 CGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKF 1046
            .||.|:..:|:|||||||||||:....:.||.|||::                  .|:..:::::
  Fly  1049 KGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLA------------------KLLSSDSNEY 1095

  Fly  1047 KFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMF 1111
            |...|.                                           :||:|:|.|.::..:|
  Fly  1096 KAAGGK-------------------------------------------MPIKWLALECIRNRVF 1117

  Fly  1112 TTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPH 1176
            |:::|:||||:.:||:.|.|..|:..:..:::...:..||:.:.|:....:.|..:..|||.:..
  Fly  1118 TSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAA 1182

  Fly  1177 MRPSFAQ 1183
            |||:|.|
  Fly  1183 MRPTFKQ 1189

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 86/336 (26%)
PTKc 860..1187 CDD:270623 86/332 (26%)
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382
GF_recep_IV 572..684 CDD:291509
FU 573..>606 CDD:238021
FU 617..659 CDD:214589
FU 662..716 CDD:214589
FU 739..786 CDD:238021
FU 784..834 CDD:214589 2/10 (20%)
PTKc_EGFR_like 930..1208 CDD:270648 87/352 (25%)
STYKc 938..1194 CDD:214568 87/338 (26%)
Recep_L_domain 128..239 CDD:279382
Furin-like 253..401 CDD:279142
FU 255..292 CDD:214589
FU 302..345 CDD:238021
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45455318
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24416
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.030

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