DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tie and fyna

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001315092.1	Gene:	fyna / 373872	ZFINID:	ZDB-GENE-030903-5	Length:	537	Species:	Danio rerio

Alignment Length:	426	Identity:	112/426 - (26%)
Similarity:	172/426 - (40%)	Gaps:	119/426 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   786 DDDEDEVDHQHHQHMQHHQN----------HQNHQNHQHHQA-----------MPMSQASQRDAN 829
            |.||.:.||..|..::...|          .:..|...||.:           :|..:...|.|
Zfish   191 DWDETKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVHHYSARAAGLCCRLIVPCHKGMPRLA- 254

  Fly   830 HNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIR-A 893
                    |.:....:..:..|.:::|...||.|.||:||       .|.:.....|||||:: .
Zfish   255 --------DLSVKTKDVWEIPRESLQLIKRLGNGQFGEVW-------MGTWNGNTKVAVKTLKPG 304

  Fly   894 CSAQVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPAS 958
            ..:..|..:||.||:|| .|..:|.|. |.|..||..::.||..:|.||..|:........||
Zfish   305 TMSPESFLEEAQIMKKL-RHDKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKDGEGRGLKLP-- 365

  Fly   959 VPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDA 1023
                         .|...|..:|.||.||.....:||||.:.|:|:..:.:|||.|||::
Zfish   366 -------------NLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGDSLVCKIADFGLA----- 412

  Fly  1024 ERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHD 1088
             |:.::.|..|..              |:::
Zfish   413 -RLIEDNEYTARQ--------------GAKF---------------------------------- 428

  Fly  1089 TIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRP 1153
                    ||:|.|||:..|..||.::|:|:|||:|.|:.|.|..||..:..|||:.:|.:|.|.
Zfish   429 --------PIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRM 485

  Fly  1154 DLPKESRHEFYNLMSRCWHKEPHMRPSF--AQSRLE 1187
            ..|::.....:.||.:||.::|..||:|  .|:.||
Zfish   486 PCPQDCPSSLHELMLQCWKRDPEERPTFEYLQAFLE 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	94/331 (28%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	94/329 (29%)
fyna	NP_001315092.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..34
		SH3_Fyn_Yrk	85..140	CDD:212939
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281	10/53 (19%)
		PTKc_Fyn	261..534	CDD:270655	98/347 (28%)
		Pkinase_Tyr	271..520	CDD:285015	95/334 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010