DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tie and Ack-like

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster

Alignment Length:	347	Identity:	99/347 - (28%)
Similarity:	145/347 - (41%)	Gaps:	91/347 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   847 HDFERSNIRLKSLLGEGNFG----QVWKAEADDLSGHFGATRI-VAVKTI---RACSAQVSLKDE 903
            |.....:|.:...||.|.||    .||..         |..|| ||:|.:   |..|..:....|
  Fly   126 HIIPADSISVNKQLGTGEFGIVQQGVWSN---------GNERIQVAIKCLCRERMQSNPMEFLKE 181

  Fly   904 ANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPL 968
            |.||..: .|:|:|.|.|..:.::..||:.|.|   .|.|||...:.:          |..::.|
  Fly   182 AAIMHSI-EHENIVRLYGVVLATDSLMLVTELA---HLRSLLECLKDS----------GLRVSFL 232

  Fly   969 SPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKN 1033
            :..||..|||.|..||.|:..:|::||||||||:|:......||.|||:|..|...:
  Fly   233 TIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGK-------- 289

  Fly  1034 AANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPI 1098
                    :.:|..|:...:                                          |||
  Fly   290 --------DYYKTNFNVNLK------------------------------------------LPI 304

  Fly  1099 RWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRV--PQGLRPDLPKESRH 1161
            .|.|||.:.|..||..:|:||||:.|||:.:.|..|::.|||.:::..:  |...|.:.|.....
  Fly   305 AWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPS 369

  Fly  1162 EFYNLMSRCWHKEPHMRPSFAQ 1183
            |:|.||.:||..:...||.|.:
  Fly   370 EYYTLMMKCWQDDAAKRPRFGE 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	98/338 (29%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	97/334 (29%)
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	98/340 (29%)
		PTKc_Ack_like	137..398	CDD:270636	97/336 (29%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.010