DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tie and Fgfrl1

DIOPT Version :9

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_954545.1 Gene:Fgfrl1 / 360903 RGDID:735156 Length:529 Species:Rattus norvegicus


Alignment Length:472 Identity:90/472 - (19%)
Similarity:145/472 - (30%) Gaps:110/472 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   315 PAVMGKGIP------SKTNSMEDDVEEEEDELKPY------VYFGAKLPPIRPGGLTIKAAEGDD 367
            |.:..|.:|      .:|..::..||.:...|..:      ::.|.....:.|.||.:|..|.:|
  Rat    25 PRMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKEVEAED 89

  Fly   368 DHPRV---------LEVSVAQSTTPTITTTSTTPAPVSSTRPTASTRRPLTPVERSRSKYKY--- 420
            ....|         |.|:........|:.....|.|..|:.....      ||.:..::.::   
  Rat    90 AGVYVCKATNGFGSLSVNYTLIIMDDISPGKENPGPGGSSGGQED------PVSQQWARPRFTQP 148

  Fly   421 -HMRERGLVPTAAPPPAAPPAPPVSRTRYVGSGRPTAG---LSDSIQDLKQTE-SEVAKPVVRRV 480
             .||.|.:         |.|.....|.:.|.||.|...   :.|. |.|.:.| ||..|......
  Rat   149 SKMRRRVI---------ARPVGSSVRLKCVASGHPRPDIMWMKDD-QTLTRLEASEHRKKKWTLS 203

  Fly   481 VQKVSPSSSTPLIITVLSAEEETTVGQTEALPTDESTTTTSTTTTTEKPSTTTSTSTTTT----- 540
            ::.:.|..|......|  :.....:..|..:...:.|.:....|.|...:||.....||:     
  Rat   204 LKNLKPEDSGKYTCRV--SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKV 266

  Fly   541 ----TPVPSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPT----TTKANSIIEKD 597
                .||....||....            :.....||.........|:||    :....|.:.| 
  Rat   267 RSDVKPVIQWLKRVEYG------------SEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNK- 318

  Fly   598 KELIRALGPALTREINIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTDSSPKILRTTVLTSIRST 662
                     .|......|||...|  |...:..|.:                 .|:..||.:...
  Rat   319 ---------LLISRARQDDAGMYI--CLGANTMGYS-----------------FRSAFLTVLPDP 355

  Fly   663 VHPRPTSTSTTTSTTTTAPPAVTAPSNEVYI-GIV------ESSSSASPADISSTVIANERDLNM 720
            ..|.|....::::|:...|..:..|:..|:| |.|      ......:||  |:..:...|....
  Rat   356 KPPGPPVAHSSSTTSLPWPVVIGIPAGAVFILGTVLLWLCQTKKKPCAPA--STLPVPGHRPPGT 418

  Fly   721 EMRRMNLVTLVLVAVGV 737
            ...|.....|..:|||:
  Rat   419 SRERSGDKDLPSLAVGI 435

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581
PTKc 860..1187 CDD:270623
Fgfrl1NP_954545.1 I-set 29..112 CDD:400151 16/82 (20%)
Ig strand A' 35..38 CDD:409353 0/2 (0%)
Ig strand B 41..50 CDD:409353 1/8 (13%)
Ig strand C 56..61 CDD:409353 1/4 (25%)
Ig strand C' 64..67 CDD:409353 0/2 (0%)
Ig strand D 72..77 CDD:409353 0/4 (0%)
Ig strand E 78..84 CDD:409353 2/5 (40%)
Ig strand F 91..99 CDD:409353 1/7 (14%)
Ig strand G 102..112 CDD:409353 2/9 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 117..152 5/40 (13%)
IgI_2_FGFRL1-like 143..234 CDD:409442 21/102 (21%)
Ig strand B 164..168 CDD:409442 1/3 (33%)
Ig strand C 177..181 CDD:409442 0/3 (0%)
Ig strand E 200..204 CDD:409442 0/3 (0%)
Ig strand F 214..219 CDD:409442 0/4 (0%)
Ig strand G 227..230 CDD:409442 0/2 (0%)
Ig 242..350 CDD:416386 25/148 (17%)
Ig strand A 242..245 CDD:409353 0/2 (0%)
Ig strand A' 249..253 CDD:409353 0/3 (0%)
Ig strand B 261..268 CDD:409353 0/6 (0%)
Ig strand C 272..279 CDD:409353 2/6 (33%)
Ig strand D 304..309 CDD:409353 1/4 (25%)
Ig strand E 317..322 CDD:409353 2/14 (14%)
Ig strand F 330..338 CDD:409353 2/9 (22%)
Ig strand G 341..349 CDD:409353 2/24 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 405..427 4/23 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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