DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and Src42A

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster

Alignment Length:	1329	Identity:	267/1329 - (20%)
Similarity:	453/1329 - (34%)	Gaps:	421/1329 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 EAIVAAAAATLSETQT------------NATNGAI---------REPPVQLQLQQQQLQLQLQLN 126
            :|:.|||||||....|            .|.:.||         :|...|.:.:::..:   :..
  Fly   490 DALAAAAAATLIGESTPPLGEAAAPLGEAAPSSAIGEKIDRRNYKECLTQSRNRRKSYE---EFK 551

  Fly   127 ATAGDGESRNSAEIFSPGDVDVVGDKPTTYRPSGANRPSIAPLNSAQDRERKLMNVLAARRTALH 191
            |...:..:..|..:..|..|....|..||      ...::.||:|..::|
  Fly   552 AMFIEPPAEASKSVTVPPPVVAPADDATT------ASSTVIPLSSISEQE--------------- 595

  Fly   192 RGGFRTRIGTTGRTAISPSAAVESTSKAPSDPRSVCIRN--------CTKNFTRRTTASCMRQCA 248
                  .||:.|... .|..|.|.|  |.:|.......|        ...:.|..|||:.....:
  Fly   596 ------NIGSRGVRG-KPDCANEFT--ASTDEMDTGDGNSDGEKGAAAEVDLTTETTATAKTLVS 651

  Fly   249 NFTRMAMPSNGN-SSVVLKGSASLKAAAPAGDRDT---------NEI----------------LF 287
            :.|..||..|.: .|.:|....:.|..|.|..|.|         |||                ..
  Fly   652 SSTTEAMRKNSDFLSQILDHQFAAKERAKAHKRRTSYEEFKRLVNEIEPLECPNTQPTVSAAVTP 716

  Fly   288 SDESSHGLFVVAKEQNGTLNHIADGTKPAVMGKGIPSKTNSMEDDVEEE---EDELKP----YVY 345
            :..::.....:.|.||..       .:.:.....:|.:.::.|...|:|   .|.:||    .:.
  Fly   717 TTATAAAAASLIKRQNSR-------QRKSFASYFLPHRHSTKEQKTEKENCSRDPIKPSQEQQLA 774

  Fly   346 FGAKLPPIRPGGLTIKAA----------------------EGDDDHPR------------VLEVS 376
            ...|||..|.....|.::                      ..:|.:.:            :|...
  Fly   775 VCGKLPLHRSNTSDISSSYYRRNFKIYDKLVYGTIYDIIQRKNDIYQKYDKYMTYGTIYEILHRK 839

  Fly   377 VAQSTTP-------TITTTSTTPAPV----------------SSTRPTASTRRPLTPVERSRSKY 418
            .:||:.|       :|.....:...:                ||:..|.||..|          :
  Fly   840 TSQSSDPWQRKSLSSILEGGRSSGDIIYDIGQRRERDKRTLGSSSSATVSTINP----------H 894

  Fly   419 KY---------------HMRERGLVPTAAPPPAAPP-APPVSRTRYVGSG-------RPTAGLSD 460
            ||               |::.:   |.....|..|| |.|   ||:|.|.       .||.....
  Fly   895 KYGTIYDILQGVKIDAGHVKNK---PDQKSKPTKPPLAKP---TRFVVSQVVEPVQIPPTDQSGK 953

  Fly   461 SIQDLKQTESEVAKP-VVRRVVQKVSPSSSTPLIITVLSAEEETTVGQTEA----------LPTD 514
            |:|:....:|.  || .:||:...:|.|.::.......:.:|||...:|:|          ||.|
  Fly   954 SVQEQGAPKSN--KPNKMRRLSNILSYSRNSGEDQQETTGKEETKPKRTQAKRRIGVTNLLLPLD 1016

  Fly   515 ESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTTSST 579
              :....|....::.......|........|..:..|.||         .|.||:..:.:.:.:.
  Fly  1017 --SEELYTRIIAQQRGLDKEHSQEPEEKCASEEQMCTRNA---------LTKSSSLDAISLSVAI 1070

  Fly   580 STTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLIVFCNNTSDCGVTPRTQTQPSHTT 644
            |....|:..:....:::.:.|.:.....|.::.::|:...::                   |.||
  Fly  1071 SPASSPSPPRPRRSLKQHRCLQQHQQTPLAKKHSLDNCLQVV-------------------SSTT 1116

  Fly   645 DSSPKILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNE---VYIGIVESSSSASPAD 706
            ...| :.|.:..|.::.|.||.......|....:.:.||..:.|..   .::.:::.|.:.:...
  Fly  1117 SRQP-LRRWSNQTPLKCTCHPATEELPLTAIEKSRSLPAACSASCSHTCAHLSVIDQSPATTKCF 1180

  Fly   707 ISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQ 771
            ..:::...::.   :.||::..|                   |...:..::..
  Fly  1181 GKTSLTTAKKG---KSRRLSEFT-------------------RGEFLNEKSWY------------ 1211

  Fly   772 PISPVKKVDSKYQVDDDEDE-----VDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQAS------- 824
             ...:|:::::.::...|:|     :.....:|..:..:.::....:|::...:.:..
  Fly  1212 -FRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGFFIARRT 1275

  Fly   825 -----QRDANHNRYGNNDD-----------------KTSLASEFHD---FERSNIRLKSLLGEGN 864
                 |....|  |..:.|                 ...|:....|   .:|::::....||.|.
  Fly  1276 TFRTLQELVEH--YSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQ 1338

  Fly   865 FGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVSLKD---EANIMRKLGSHQNVVTLLGACVES 926
            ||.||:       |.:..|..||:||::  |..:..||   ||.||:|| .|..::.|...|...
  Fly  1339 FGDVWE-------GLWNNTTPVAIKTLK--SGTMDPKDFLAEAQIMKKL-RHTKLIQLYAVCTVE 1393

  Fly   927 EPHMLIMEYAMRGRLLSLLRAARSATNILPASVPG-GRSLAPLSPRTLAGFALDIACGMEYIAGR 990
            ||..:|.|....|.||..|:|           :.| |||   |..:||...|..||.||.|:..:
  Fly  1394 EPIYIITELMKHGSLLEYLQA-----------IAGKGRS---LKMQTLIDMAAQIAAGMAYLESQ 1444

  Fly   991 RIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYI 1055
            ..:||||||||||:....:.||.|||::      |:.||.|..|.              .|:|:
  Fly  1445 NYIHRDLAARNVLVGDGNIVKIADFGLA------RLIKEDEYEAR--------------VGARF- 1488

  Fly  1056 LQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAF 1120
                                                     ||:|.|||:..|..|:.::|:|:|
  Fly  1489 -----------------------------------------PIKWTAPEAANYSKFSIKSDVWSF 1512

  Fly  1121 GIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSR 1185
            ||:|.|:.|.|..||..:|..||:.:|..|.|...|.......|.:|..||||:|..||:|
  Fly  1513 GILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTF---- 1573

  Fly  1186 LEITRSLHKWVDDD---SAASDYMDVSGF 1211
                 ...:|..:|   |..|||.:...:
  Fly  1574 -----ETLQWKLEDFYTSDQSDYKEAQAY 1597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	105/332 (32%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	105/330 (32%)
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	9/105 (9%)
		PTKc_Frk_like	1319..1587	CDD:270653	109/362 (30%)
		Pkinase_Tyr	1328..1580	CDD:285015	106/346 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.010