Protein Alignment Tie and dnt

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_001260567.1
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Alignment Length: 605
• Identity: 132/605 - (21%)
• Similarity: 208/605 - (34%)
• Gaps: 229/605 - (37%)

  Fly   667 PTSTSTTTSTTTTAP-PAV-TAPSNEV-------YIGIVESSSSASPAD--ISSTVIANERDLN- 719
            |.|.:..:|.....| ||: .:.|.|:       .|.:..|...|:..|  :|..|:.| |.||
  Fly   105 PYSINVVSSDQEVLPRPAINVSHSGEIPTTIQTWSIALKCSGLKAAEVDVTVSLEVVLN-RSLNN 168

  Fly   720 ---MEMRR-----MN-------------------------LVTLVL---VAVGVIPLAAIILYLV 748
               :..||     ||                         |:|||:   ||:|.:.|..:|.|.|
  Fly   169 VTHLVFRRKKICLMNDSAEDLSEDVDDPQLLETVMLPPTGLITLVVGVSVAMGSVCLLLMIAYCV 233

  Fly   749 RNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQ 813
            :....:|                                       |||||........:.|...
  Fly   234 KGAANKR---------------------------------------QHHQHGGQPMRTSSFQRLN 259

  Fly   814 HHQAMPMSQASQRDANHNR-------YGNNDDKTSLAS-------EFH------DFERSNIRLKS 858
            .|   |..|:|...|.:..       :|::..:....|       |.|      ..||..:||.|
  Fly   260 TH---PPCQSSMGSAAYMTPSIIAPIHGSSLPRKVPVSVEQQHPEELHRRISELTVERCRVRLSS 321

  Fly   859 LLGEGNFGQVWKAEADDLSGHFGATRIVAVKTI--RACSAQVSLKDEANIMRKLGSHQNVVTLLG 921
            ||.||.||:|::       |.:..|:.|.|||:  .|...||.|..:..::....||..::::||
  Fly   322 LLQEGTFGRVYR-------GTYNDTQDVLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLG 379

  Fly   922 ACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFALDIAC---- 982
            ..:|......::..|:.                              :.|.|..|.||.||
  Fly   380 VSIEDHTTPFVLYPALN------------------------------NTRNLKQFLLDPACARTV 414

  Fly   983 --------------GMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKN 1033
                          .::::....:||:|:|.||.::|.....|:.|..:|.||
  Fly   415 TTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDL------------ 467

  Fly  1034 AANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPI 1098
                            |.|.|                :|                 :|.....|:
  Fly   468 ----------------FPSDY----------------NC-----------------LGDSENRPV 483

  Fly  1099 RWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEF 1163
            :||:.|:||:..|:..:|.||||:::||:.|....||:::...|:...:..|.|...|.....|.
  Fly   484 KWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDEL 548

  Fly  1164 YNLMSRCWHKEPHMRPSFAQ 1183
            :.:|:.||...|..||:|||
  Fly   549 FTIMAYCWALLPAERPTFAQ 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	79/348 (23%)
		PTKc	860..1187	CDD:270623	77/344 (22%)
dnt	NP_001260567.1	WIF	46..182	CDD:128745	20/77 (26%)
		PKc_like	310..580	CDD:304357	83/357 (23%)
		Pkinase_Tyr	317..573	CDD:285015	81/350 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455327
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030