Protein Alignment Tie and Btk29A

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_001097121.1
• Gene: Btk29A / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Alignment Length: 848
• Identity: 189/848 - (22%)
• Similarity: 301/848 - (35%)
• Gaps: 237/848 - (27%)

  Fly   411 VERSRSKYKYHMR-----ERGLVPTAAPPPAAPPAPPVSRTRYV-----------------GSGR 453
            |||.|.:.:.|::     |...|......|.||...|. :..|.                 |||.
  Fly    83 VERRRERGRIHLKGVRLVEEATVSGEGGDPFAPDGYPF-QVGYCEISASANSHQLENGNGGGSGV 146

  Fly   454 PTAGLSD-------SIQDLKQTESEVAKPVVRRVVQKVSPSSSTPLIITVLSAEEETTVGQTEAL 511
            ...|...       ::..:..:|.|.::.:  |.:::|...|:||
  Fly   147 GIEGQQSGRAVPQYTLYVIANSEKERSEWI--RAIRQVCEDSNTP-------------------- 189

  Fly   512 PTDESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTT 576
               :|........:.:|.|.....|.||.....:...|...|.|.:.::....:|.|.:|:::||
  Fly   190 ---KSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGSSPAQNSTRSISPNSSTT 251

  Fly   577 SSTSTTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLIVFCNNTSDCGVTPRT-QTQP 640
                          ||..........:||..:...:....:..|.........|  ||.: |.|.
  Fly   252 --------------NSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSC--TPTSLQPQS 300

  Fly   641 SHTT-DSSPKIL--RTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEVYIGIVES---S 699
            |.|| ..||.:|  ..|:|.:......|.|            ..|...|..|..::.:|.:   .
  Fly   301 SLTTFKQSPTLLNGNGTLLDANMPGGIPTP------------GTPNSKAKDNSHFVKLVVALYPF 353

  Fly   700 SSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAI----ILYLVR-----NFVIRR 755
            .:....|:|....|....::........|...|..||.||...:    :|.|.|     ..:.|:
  Fly   354 KAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQ 418

  Fly   756 RA----KQSEVFDVCITDQQPISPVKKVDSK--YQVD-DDEDEVDHQHHQHMQHHQNHQNHQNHQ 813
            ||    ||.        |::....|:|..:|  |.:. ..:....|..|.|::.:...:.:.:.:
  Fly   419 RAESLLKQG--------DKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEK 475

  Fly   814 H-HQAMPMSQASQRD-ANHNRYGNNDDKTSLAS------------------EFHDFERSNIRLKS 858
            | .:.:|       | .|::|:.:......|.|                  |.|..|   :.|..
  Fly   476 HCCETIP-------DLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPME---LMLME 530

  Fly   859 LLGEGNFGQV----WKAEADDLSGHFGATRIVAVKTIR-ACSAQVSLKDEANIMRKLGSHQNVVT 918
            .||.|.||.|    |:...|           .|||.:: ...::....:||.:|.|| .|.|:|.
  Fly   531 ELGSGQFGVVRRGKWRGSID-----------TAVKMMKEGTMSEDDFIEEAKVMTKL-QHPNLVQ 583

  Fly   919 LLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFALDIACG 983
            |.|.|.:..|..::.||...|.||:.||  |....::     |...|       |....:.::.|
  Fly   584 LYGVCSKHRPIYIVTEYMKHGSLLNYLR--RHEKTLI-----GNMGL-------LLDMCIQVSKG 634

  Fly   984 MEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKF 1048
            |.|:.....:||||||||.|:....:.|:.|||:
  Fly   635 MTYLERHNYIHRDLAARNCLVGSENVVKVADFGL------------------------------- 668

  Fly  1049 DFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTT 1113
               :||:|.. |:|...|.                           ..||:|..||.|.|..|::
  Fly   669 ---ARYVLDD-QYTSSGGT---------------------------KFPIKWAPPEVLNYTRFSS 702

  Fly  1114 ETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMR 1178
            ::|:||:|:::|||.|.|..||.:|...||:.||.:|:..:.||....|.|::|..||...|..|
  Fly   703 KSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEER 767

  Fly  1179 PSF 1181
            |:|
  Fly   768 PAF 770

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	93/333 (28%)
		PTKc	860..1187	CDD:270623	92/327 (28%)
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	29/164 (18%)
		SH3_Tec_like	346..399	CDD:212702	10/52 (19%)
		SH2_Tec_family	403..505	CDD:198188	23/116 (20%)
		PTKc_Tec_like	521..778	CDD:173637	95/341 (28%)
		Pkinase_Tyr	526..777	CDD:285015	93/333 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.010