DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and yrk

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001352482.1	Gene:	yrk / 337571	ZFINID:	ZDB-GENE-030131-9517	Length:	528	Species:	Danio rerio

Alignment Length:	344	Identity:	104/344 - (30%)
Similarity:	149/344 - (43%)	Gaps:	91/344 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   848 DFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIR--ACSAQVSLKDEANIMRKL 910
            :..|.:::|...||.|.||:||       .|.:..|..|||||::  ..|.:..| |||.||::|
Zfish   256 EIPRESLQLIKKLGNGQFGEVW-------MGMWNGTTKVAVKTLKPGTMSPEAFL-DEAQIMKRL 312

  Fly   911 GSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAG 975
             .|..:|.|. |.|..||..:|.|:..:|.||..|:........||               .|..
Zfish   313 -RHDKLVQLY-AVVSEEPIYIITEFMSQGSLLDFLKDGDGRNLKLP---------------QLVD 360

  Fly   976 FALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMR 1040
            .|..||.||.||.....:||||.|.|:|:....:|||.|||::      |:.::.|..|..
Zfish   361 MAAQIAAGMAYIERMNYIHRDLRAANILVGDGLVCKIADFGLA------RLIEDNEYTARQ---- 415

  Fly  1041 HNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPES 1105
                      |:::                                          ||:|.|||:
Zfish   416 ----------GAKF------------------------------------------PIKWTAPEA 428

  Fly  1106 LQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRC 1170
            ..|..||.::|:|:|||:|.|:.|.|..||..:..|||:.:|.:|.|...|:.|....:.||.:|
Zfish   429 ALYGKFTIKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVERGYRMPCPQGSPASLHELMLQC 493

  Fly  1171 WHKEPHMRPSF--AQSRLE 1187
            |.|:|..|.:|  .||.||
Zfish   494 WRKDPDERHTFEYLQSFLE 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	99/332 (30%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	100/330 (30%)
yrk	NP_001352482.1	SH3	76..133	CDD:327375
		SH2	136..234	CDD:326550
		PTKc_Src_Fyn_like	266..513	CDD:271105	102/334 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010