DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tie and Ddr

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001014474.3	Gene:	Ddr / 3346209	FlyBaseID:	FBgn0053531	Length:	1054	Species:	Drosophila melanogaster

Alignment Length:	392	Identity:	110/392 - (28%)
Similarity:	162/392 - (41%)	Gaps:	95/392 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   814 HHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSG 878
            ||..:.|| |:..|.|..|..         .:..:|.|.::.:...||.|.||::...|.:.|:
  Fly   729 HHYNLDMS-ANFADINEERAN---------CQVQEFPRQSLVIVEKLGSGVFGELHLCETNVLN- 782

  Fly   879 HFGATRIVAVKTIRACSAQVSLKDE----ANIMRKLGSHQNVVTLLGACVESEPHMLIMEYA-MR 938
               || :|||.|:|. .|...|:.|    |..:.:| |..||..|:|||:..||..::.:|: ..
  Fly   783 ---AT-LVAVATLRP-GANDHLRKEFRSKAKQLAQL-SDPNVARLVGACLRDEPICIVQDYSHCL 841

  Fly   939 GRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVL 1003
            |.|...|:...:.|:.|.|.       ..||...|...|..||.||:::.....||||||.|:.:
  Fly   842 GDLNQFLQEHVAETSGLMAK-------KSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCI 899

  Fly  1004 LDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQG 1068
            :......|:|..|..|:..|                          :.|.|.           |.
  Fly   900 IGPELCVKVCSIGTVINRSA--------------------------YASDYC-----------QL 927

  Fly  1069 QGHCSK-DQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLG- 1131
            :|...: .||                  :||||||.||:....|||::|:|:|.:.||||.|..
  Fly   928 EGFTGRQSQP------------------MPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAR 974

  Fly  1132 STPYSQLTGREVIRRV--------PQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEI 1188
            ..||..|:.:.||..:        ...|.| :|.....|.|:||..||.::...||||.:..|.:
  Fly   975 EQPYEHLSDKSVIENIGLIYRDYKMHELLP-MPPNCPREIYDLMCECWQRDESSRPSFREIHLYL 1038

  Fly  1189 TR 1190
            .|
  Fly  1039 QR 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	98/343 (29%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	98/341 (29%)
Ddr	NP_001014474.3	FA58C	106..262	CDD:214572
		FA58C	109..261	CDD:238014
		PTKc_DDR	753..1040	CDD:270644	101/356 (28%)
		TyrKc	759..1038	CDD:197581	99/348 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455257
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030