DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tie and sev

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster

Alignment Length:	340	Identity:	107/340 - (31%)
Similarity:	154/340 - (45%)	Gaps:	82/340 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   852 SNIRLKSLLGEGNFGQVWKAE--ADDLSGHFGATRIVAVKTIR-ACSAQVSLKDEANIMRKLGSH 913
            |.::|...||.|.||:|::.:  .:|..    ..:.||:|::| ..|....|..||.:|... .|
  Fly  2207 SQLKLLRFLGSGAFGEVYEGQLKTEDSE----EPQRVAIKSLRKGASEFAELLQEAQLMSNF-KH 2266

  Fly   914 QNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFAL 978
            :|:|.|:|.|.::|...||||:...|.|||.|||||:.:...|....|      ||...|....:
  Fly  2267 ENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAG------LSLSELLAMCI 2325

  Fly   979 DIACGMEYIAGRRIVHRDLAARNVLL-------DHNGMCKICDFGMSIDLDAERMRKEQEKNAAN 1036
            |:|.|..|:.....||||||.||.|:       |.....||.|||::.|:
  Fly  2326 DVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDI--------------- 2375

  Fly  1037 DLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWM 1101
                     :|.|:..:             :|:|                        .||:|||
  Fly  2376 ---------YKSDYYRK-------------EGEG------------------------LLPVRWM 2394

  Fly  1102 APESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNL 1166
            :||||...:|||::|:||||::.|||.|||..||:.....||:..|.:|.|...|.....:.|:|
  Fly  2395 SPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSL 2459

  Fly  1167 MSRCWHKEPHMRPSF 1181
            :..||..:|..||||
  Fly  2460 LLLCWRTDPWERPSF 2474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	106/338 (31%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	105/332 (32%)
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020
		FN3	1993..2111	CDD:238020
		Pkinase_Tyr	2209..2481	CDD:285015	106/338 (31%)
		PTKc_c-ros	2213..2483	CDD:270640	105/334 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455271
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940