Protein Alignment Tie and tie1

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: XP_001334673.5
• Gene: tie1 / 30746
• ZFINID: ZDB-GENE-990415-55
• Length: 1122
• Species: Danio rerio
• Alignment Length: 1178
• Identity: 252/1178 - (21%)
• Similarity: 391/1178 - (33%)
• Gaps: 453/1178 - (38%)

  Fly   188 TALHRGGFRTRIGTTGRTAISPSAAVESTSKAPSDPRSV----------CIRNCTKN-FTRRTTA 241
            ||...|.|    |...:.:..|....:..|...:||...          |.:.|.:. :......
Zfish   245 TACREGMF----GRNCQESCKPENGCQGLSFCLTDPYGCSCASGWHGDRCRKPCLEGMYGADCLL 305

  Fly   242 SCMRQCANFTRMAMPSNGNSSVVLKGSASLKAAAPAGDRDTNEILFSDESSHGLFVVAKEQNGTL 306
            ||  .|.|..:....|....|...:|....|:     || ..|||          .:|....|.|
Zfish   306 SC--NCKNKGKCNRFSGCQCSTGWRGQYCEKS-----DR-APEIL----------DIASNLEGNL 352

  Fly   307 NHIADGTKPAVMGKGIPS----KTNSMEDDVEEE----EDELKPYVYFGAKLPPIRP-------- 355
            |.....|..|. |..:||    :...:|..|.:.    .|..|...:|  ::|.:.|
Zfish   353 NSSHKITCSAT-GHPLPSHLSIELRKLESTVLKAFHTILDSKKSTAHF--EIPRLSPEHNGLWEC 414

  Fly   356 -----GG-------LTIKAAEGDDDHPRVLEVSVAQSTTPTITTTSTTPAPVSSTR---PTASTR 405
                 ||       ||:|........|::|..|..|.....:.:.: ...|:.||:   ...:|.
Zfish   415 RVSTNGGQDSLKFTLTVKEPPYPTAAPKLLLRSSRQLVVKAVDSYA-GDGPIVSTKLLYKQVNTE 478

  Fly   406 RPLTPV----------ERSRSKYKYHMR-------ERG--------LVPTAAPPPAAPPAPPVS- 444
            ...:|:          :..:...|||:|       |.|        ::.|..|.|.|.|....|
Zfish   479 DSWSPIIVHGSDQITLQNLKPSTKYHVRVQLARPGEGGEGPLGPEAIMETDCPEPTARPEIDSSS 543

  Fly   445 --------RTRYVGSGRPTAG----------------------LSDSIQDLKQTESEVAKPVVRR 479
                    |...:|..|..:|                      ||..:.:|:..::..|  |||.
Zfish   544 LEGRNVTLRWSLIGRFREASGFLVQLYGPYGEKLWEETTFLNVLSVKLYNLEYHKNYQA--VVRL 606

  Fly   480 V---------------VQKVSPSSSTPLIITVLSAE---------------------EETTVGQT 508
            |               :.|..|||...:....||..                     |...|||:
Zfish   607 VNCGSHGPPSRPHHIHIYKQGPSSPRNVQADALSISAVRLRWQPPEDPNGGIVKYSIEYQPVGQS 671

  Fly   509 EALP---TDESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSSTT 570
            ...|   ||....||       |..|:.:.||.....|.:.||.....:......||....||
Zfish   672 SLHPWVDTDNGNKTT-------KDVTSLNGSTLYQFRVRAFSKVPGEWSSFVQAQTPGEGLSS-- 727

  Fly   571 PSTTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLIVFCNNTSDCGVTPR 635
                        .||||.:....:.:|.:|:.|
Zfish   728 ------------FIPTTQQVGRPLAEDHQLLFA-------------------------------- 748

  Fly   636 TQTQPSHTTDSSPKILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEVYIGIVESSS 700
                               |:.|:                       |||.
Zfish   749 -------------------VVGSV-----------------------AVTC-------------- 757

  Fly   701 SASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDV 765
                                       ||::        ||.:.|:.:|..|::||...:
Zfish   758 ---------------------------VTIL--------LALLALFYIRKSVLKRRRTFT----- 782

  Fly   766 CITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANH 830
                             ||....|:.:       :|.:...............|::
Zfish   783 -----------------YQSGSGEETI-------LQFNSGTLTLTRRPKPSPEPLT--------- 814

  Fly   831 NRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKA--EADDLSGHFGATRIVAVKTIRA 893
                           :...|..:|:.:.::||||||||.||  :.|      |.....|:|.::.
Zfish   815 ---------------YPILEWEDIKFEDVIGEGNFGQVIKAMVKKD------GIKMSAAIKMLKE 858

  Fly   894 CSAQVSLKD---EANIMRKLGSHQNVVTLLGACVESEPHMLI-MEYAMRGRLLSLLRAARSATNI 954
            .:::...:|   |..::.|||.|.|::.|:||| |:..::.| :|||..|.||..||.:|    :
Zfish   859 FASENDHRDFAGELEVLCKLGQHTNIINLIGAC-ENRGYLYIAIEYAPYGNLLDFLRKSR----V 918

  Fly   955 L---PASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFG 1016
            |   ||......:.:.|:.:.|..||.|:|.||.|::.::.:||||||||||:..|.:.||.|||
Zfish   919 LETDPAFAKEHGTASTLTSQQLLQFAADVATGMHYLSDKQFIHRDLAARNVLVGDNLVAKIADFG 983

  Fly  1017 MSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEK 1081
            :|        |.|:.                      |:                         |
Zfish   984 LS--------RGEEV----------------------YV-------------------------K 993

  Fly  1082 KSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRR 1146
            |      |:|:   ||:||||.|||.|.::||::|:|:||::||||.:||.|||..:|..|:..:
Zfish   994 K------TMGR---LPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEK 1049

  Fly  1147 VPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVSGF 1211
            :|||.|.:.|:....|.|.||.:||...|:.||.|:|..:::.|.       ..|...|::::.|
Zfish  1050 LPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFSQISVQLNRM-------QEARKAYVNMALF 1107

  Fly  1212 SEDLEHGV 1219
            ......|:
Zfish  1108 ENFTYAGI 1115

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	115/337 (34%)
		PTKc	860..1187	CDD:270623	115/335 (34%)
tie1	XP_001334673.5	EGF_CA	<219..244	CDD:238011
		IG_like	346..431	CDD:214653	18/87 (21%)
		fn3	<461..508	CDD:278470	9/46 (20%)
		fn3	538..616	CDD:278470	13/79 (16%)
		FN3	628..720	CDD:238020	21/98 (21%)
		PKc_like	820..1116	CDD:304357	121/378 (32%)
		Pkinase_Tyr	823..1091	CDD:285015	116/342 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900