Protein Alignment Tie and Csf1r

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_001424441.1
• Gene: Csf1r / 307403
• RGDID: 2425
• Length: 978
• Species: Rattus norvegicus
• Alignment Length: 934
• Identity: 201/934 - (21%)
• Similarity: 319/934 - (34%)
• Gaps: 304/934 - (32%)

  Fly   454 PTAGLSDSIQDLKQTESEVAKPVVRRVVQKVSP------------SSSTPLIITVLSAEEETTVG 506
            ||  |.||:..::    |..:||.|:.|....|            .|.|.:...|::|.|.|::|
  Rat   132 PT--LKDSVSLVR----EWGRPVSRKTVYSFLPWRGFIIHKAKFLDSHTYMCKAVVNARESTSIG 190

  Fly   507 ----QTEALP---------------TDESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTS----- 547
                ...|.|               ..|:.....:.|.:|...........|...:|..|
  Rat   191 IRLKVNRAHPGPPHIILEPTKLVRIRGEAAQIVCSATHSEVEFNVILKRGDTKLEIPINSDFQDN 255

  Fly   548 ---KRTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPALT 609
               |..|.|  |:..:.......|...:....|:|:|........|...:..::.|:
  Rat   256 AYKKVLTLN--LNAVDFQDAGIYSCVANNAAGSNTATMNFQVVESAYLNLTSEQSLL-------- 310

  Fly   610 REINIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTDSSPKILR--TTVLTSIRSTVHPRPTSTST 672
            :|:::.:..:|.|.                    .|:.|.:.|  .|.|.......|.....|..
  Rat   311 QEVSVGENLDLTVI--------------------ADAYPGLQRYNWTYLGPFFEDPHNLEFRTQW 355

  Fly   673 TTST------TTTAPP------AVTAPSNEVYIGIVESSSSASPADISSTVIANERDLNMEMRRM 725
            ||.:      .....|      ::.|.:...:..:....:...|.::|.|.|.           :
  Rat   356 TTYSYSFKLHLNRVKPLEAGRYSLMAQNKAGWNNLTFELTLRYPPEVSVTWIP-----------V 409

  Fly   726 NLVTLVLVAVGVIPLAAIILYLVRNFVIR-RRAKQSEVFD--------------VCITDQQPISP 775
            |...::|..|...|...:.....|....| ..|:.|:|:|              |.:..|.||..
  Rat   410 NGSDVLLCDVSGYPQPNVTWMECRGHTDRCDEAQASQVWDDTQPEVLSQKPFHRVILQSQLPIGT 474

  Fly   776 VKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQ--------------- 825
            :|                |......:.|.|..|  :.|..:|:.:.|:.|
  Rat   475 LK----------------HNMTYVCRAHNNVGN--SSQFFRAISLGQSKQLPDEYLFTPVVVACI 521

  Fly   826 ---------------RDANHNRY-----------GNN---DDKTSLA-SEFHDFERSNIRLKSLL 860
                           :.....:|           |||   .|.|.|. :|..:|.|:|::....|
  Rat   522 SVMSLLVLLLLLLLYKYKQKPKYQVRWKIIESYEGNNYTFIDPTQLPYNEKWEFPRNNLQFGKTL 586

  Fly   861 GEGNFGQVWKAEADDLSGHFGATRIVAVKTIRA---CSAQVSLKDEANIMRKLGSHQNVVTLLGA 922
            |.|.||:|.:|.|..| |...|...||||.:::   ...:.:|..|..||..||.|:|:|.||||
  Rat   587 GAGAFGKVVEATAFGL-GKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGA 650

  Fly   923 CVESEPHMLIMEYAMRGRLLSLLRAARSA---TNILPASVPGGRS-------------------- 964
            |....|.::|.||...|.||:.||....|   .::.|...|.|.|
  Rat   651 CTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGDSSYKNIHLEKKYVRRDSGFSS 715

  Fly   965 --------LAPLSPRT---------------------LAGFALDIACGMEYIAGRRIVHRDLAAR 1000
                    :.|:|..:                     |..|:..:|.||.::|.:..:|||:|||
  Rat   716 QGVDTYVEMRPVSTSSNDSFFKQDLDKEASRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAAR 780

  Fly  1001 NVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQ 1065
            ||||....:.||.|||::.|:          .|.:|.:::.||.
  Rat   781 NVLLTSGHVAKIGDFGLARDI----------MNDSNYVVKGNAR--------------------- 814

  Fly  1066 GQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATL 1130
                                          ||::||||||:...::|.::|:|::||:||||.:|
  Rat   815 ------------------------------LPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSL 849

  Fly  1131 GSTPY-SQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSF--------AQSRL 1186
            |..|| ..|...:..:.|..|.:...|..:....|::|..||..||..||:|        .|:||
  Rat   850 GLNPYPGILVNNKFYKLVKDGYQMAQPVFAPENIYSIMQSCWDLEPTKRPTFQQICFLLQEQARL 914

  Fly  1187 EITRSLHKWVDDDSAASDYMDVSG 1210
            |.....:..:...|::|.....||
  Rat   915 ERREQDYANLPSSSSSSSSSSDSG 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	105/392 (27%)
Csf1r	NP_001424441.1	None