Protein Alignment Tie and HCK

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_002101.2
• Gene: HCK / 3055
• HGNCID: 4840
• Length: 526
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 141/581 - (24%)
• Similarity: 232/581 - (39%)
• Gaps: 155/581 - (26%)

  Fly   661 STVHPRPTSTSTTTSTTTTAPPAVTAPSNEVYIGIVESSSSASPADIS-----STVIANERDLNM 720
            ||:.|.|.|.::.|      |....|.|.::.:..:....:....|:|     ..|:..|.....
Human    57 STIKPGPNSHNSNT------PGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWW 115

  Fly   721 EMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVF--------DVCITDQQPISPVK 777
            :.|     :|.....|.||         .|:|.|..:.::|.:        |   .::|.::|..
Human   116 KAR-----SLATRKEGYIP---------SNYVARVDSLETEEWFFKGISRKD---AERQLLAPGN 163

  Fly   778 KVDSKYQVDDDED----------EVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNR 832
            .:.| :.:.|.|.          :.|.:....::|::.........:..........|...:|.:
Human   164 MLGS-FMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYK 227

  Fly   833 YGNND--DKTSL-----------ASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATR 884
            .||:.  .|.|:           ..:..:..|.:::|:..||.|.||:||.|.       :....
Human   228 KGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMAT-------YNKHT 285

  Fly   885 IVAVKTIRACSAQV-SLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAA 948
            .|||||::..|..| :...|||:|:.| .|..:|. |.|.|..||..:|.|:..:|.||..|::.
Human   286 KVAVKTMKPGSMSVEAFLAEANVMKTL-QHDKLVK-LHAVVTKEPIYIITEFMAKGSLLDFLKSD 348

  Fly   949 RSATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKIC 1013
            ..:...||               .|..|:..||.||.:|..|..:||||.|.|:|:..:.:|||.
Human   349 EGSKQPLP---------------KLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIA 398

  Fly  1014 DFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPH 1078
            |||::      |:.::.|..|..              |:::
Human   399 DFGLA------RVIEDNEYTARE--------------GAKF------------------------ 419

  Fly  1079 GEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREV 1143
                              ||:|.|||::.:..||.::|:|:|||:|.||.|.|..||..::..||
Human   420 ------------------PIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEV 466

  Fly  1144 IRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASD 1204
            ||.:.:|.|...|:....|.||:|.|||...|..||:|     |..:|:   :||...|::
Human   467 IRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTF-----EYIQSV---LDDFYTATE 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	99/329 (30%)
		PTKc	860..1187	CDD:270623	98/327 (30%)
HCK	NP_002101.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		SH3	82..137	CDD:302595	12/68 (18%)
		SH2_Src_HCK	140..243	CDD:198226	15/106 (14%)
		PKc_like	254..524	CDD:304357	105/360 (29%)
		Pkinase_Tyr	262..511	CDD:285015	101/342 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010