DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tie and ret

DIOPT Version :9

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_858048.2 Gene:ret / 30512 ZFINID:ZDB-GENE-980526-307 Length:1106 Species:Danio rerio


Alignment Length:1158 Identity:248/1158 - (21%)
Similarity:400/1158 - (34%) Gaps:376/1158 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   188 TALHRGGFRTRIGTTGRTAIS------------PSAAVEST---SKAPS----DPRSVCIRNCTK 233
            ::|..|..|:....|.:..:|            |:..|:.:   ..|||    :..::|......
Zfish    94 SSLRSGSVRSPKDLTLKVGVSSTPPMKVMCTILPTVEVKLSFINDTAPSCGQVELSTLCFPEKIS 158

  Fly   234 N--FTRRTTASCMRQCANFTRMAMPSNGNSSVVLKGSASLKAAAPAGDRDTNEILFSDESSHGLF 296
            |  .|.......:||...||.|::..|...|..:...:|:..|.             |:|:..|.
Zfish   159 NPHITENREPGALRQLRRFTHMSICPNYTISYGVVAGSSVPFAV-------------DDSTSELV 210

  Fly   297 VVAKEQNGTLNHIADGTKPAVMGKGIPSKTNSMEDDVEE----------EEDELKPYVYFGAKLP 351
            |.|:         .|..:..|....|.....: |.::||          :||:..|||       
Zfish   211 VTAQ---------VDREEKEVYHLDIVCMVRT-ERNLEEVFRSLHVNIYDEDDNSPYV------- 258

  Fly   352 PIRPGGLTIKAAEGDDDHPRVLEVSVAQST---TPTITTTSTTPAPVSSTRPTASTRRPLTPVER 413
                        .|.|....::|...::.|   |..:....|||     ..||...:..|.....
Zfish   259 ------------NGTDTEDVLVEFDRSEGTVFGTLFVYDRDTTP-----VYPTNQVQNKLVGTLM 306

  Fly   414 SRSKY-------KYHMRERGLVPTAAPPPAAPPAPPVSRTRYVGSGRPTAGLSDSIQDLKQTESE 471
            :...:       ::..||...:                    .|:.|.|      :.:.|     
Zfish   307 TNDSWIKNNFAIEHKFREEKAI--------------------FGNVRGT------VHEYK----- 340

  Fly   472 VAKPVVRRVVQKVSPSSSTPLIITVLSAEEETTVGQTEALPTDESTTTTSTTTTTEKPSTTTSTS 536
                  .::.|.:|.:.....::..|                      .:.||......|.....
Zfish   341 ------LKLSQNLSVTEQRSFLLGYL----------------------VNDTTFPGPEGTVLLHF 377

  Fly   537 TTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKELI 601
            ..|..|||.    ..:|...|.|.:...||.|........:......|..|.:...:........
Zfish   378 NVTVLPVPI----RFSNVTYSFTVSQKATTYSQIGKVCVENCQKFKGIDVTYQLEIVDRNITAEA 438

  Fly   602 RALGPALTREINIDDANNLIVFCNNTSDCGVTPRTQTQPSH----TTDSSPKILRTTVLT----- 657
            ::...|::...|.:| |..:::.|:|.   |..|.:.|...    ..:...|:...|.||     
Zfish   439 QSCYWAVSLAQNPND-NTGVLYVNDTK---VLRRPECQELEYVVIAQEQQNKLQAKTQLTVSFQG 499

  Fly   658 ---SIRSTVHPR---------------------PT---------STSTTTSTTTTAPPAVTAPSN 689
               |:: |..||                     ||         ....:...:|.:|...|.|..
Zfish   500 EADSLK-TDEPRFPACAEKRQRGDCEATRGLGAPTGRCQWRQGRDKGISKRYSTCSPNLGTCPDG 563

  Fly   690 EVYIGIVESSS-SASPADISSTVIAN--ERDL----------------------NMEMRRMNLVT 729
              |...:||.: |..|.|.||..|..  ||||                      ..|....|.:.
Zfish   564 --YCDAIESKNISICPQDCSSEAIIGGYERDLYGIKAGHGTCYCFEGKCFCERDEPEDDICNDMC 626

  Fly   730 LVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDH 794
            ..::|.|:| |:.|:..|:.::.|.|..|.:           |..|:...:..::          
Zfish   627 KTVIATGII-LSFIVSVLLSSYFIHRYHKTT-----------PKPPIASAEMTFR---------- 669

  Fly   795 QHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFH------------ 847
                              :..|:.|:|.::          ||..:.||.|..:            
Zfish   670 ------------------RPAQSYPISYSA----------NNVRRASLDSMENQVAIDTFKIPED 706

  Fly   848 ---DFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVSLKD---EANI 906
               :|.|.|:.|...||||.||:|.||.|..|.|..|.| .||||.::..::...|:|   |..:
Zfish   707 PKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYT-TVAVKMLKENASHSELRDLLSEFTL 770

  Fly   907 MRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSA----------TNILPASVPG 961
            :::: :|.:|:.:.|||.:..|..||:|||..|.|.:.||.:|..          .|......|.
Zfish   771 LKQV-NHPHVIKMYGACSQDGPLYLIVEYAKYGSLRNFLRESRKVGPSYMGNDANRNSSYLENPD 834

  Fly   962 GRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERM 1026
            .|:   |:...|..||..|:.||:|:|..::|||||||||||:......||.|||:|.|:..|  
Zfish   835 ERA---LTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEE-- 894

  Fly  1027 RKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIG 1091
                                     ..|:                         |:|        
Zfish   895 -------------------------DSYV-------------------------KRS-------- 901

  Fly  1092 KRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLP 1156
             :..:|::|||.|||..|::||::|:|:||::||||.|||..||..:....:...:..|.|.:.|
Zfish   902 -KGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKP 965

  Fly  1157 KESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVS 1209
            :....|.||||.|||.:|...||:|:....|:.:.:.|       :.||:|::
Zfish   966 ENCTDEMYNLMLRCWKQESDKRPTFSDISKELEKMMVK-------SRDYLDLA 1011

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 110/341 (32%)
PTKc 860..1187 CDD:270623 109/339 (32%)
retNP_858048.2 CA 186..256 CDD:214520 16/92 (17%)
PTKc_RET 715..1004 CDD:173631 113/361 (31%)
Pkinase_Tyr 716..997 CDD:285015 110/346 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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