Protein Alignment Tie and ret

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_858048.2
• Gene: ret / 30512
• ZFINID: ZDB-GENE-980526-307
• Length: 1106
• Species: Danio rerio
• Alignment Length: 1158
• Identity: 248/1158 - (21%)
• Similarity: 400/1158 - (34%)
• Gaps: 376/1158 - (32%)

  Fly   188 TALHRGGFRTRIGTTGRTAIS------------PSAAVEST---SKAPS----DPRSVCIRNCTK 233
            ::|..|..|:....|.:..:|            |:..|:.:   ..|||    :..::|......
Zfish    94 SSLRSGSVRSPKDLTLKVGVSSTPPMKVMCTILPTVEVKLSFINDTAPSCGQVELSTLCFPEKIS 158

  Fly   234 N--FTRRTTASCMRQCANFTRMAMPSNGNSSVVLKGSASLKAAAPAGDRDTNEILFSDESSHGLF 296
            |  .|.......:||...||.|::..|...|..:...:|:..|.             |:|:..|.
Zfish   159 NPHITENREPGALRQLRRFTHMSICPNYTISYGVVAGSSVPFAV-------------DDSTSELV 210

  Fly   297 VVAKEQNGTLNHIADGTKPAVMGKGIPSKTNSMEDDVEE----------EEDELKPYVYFGAKLP 351
            |.|:         .|..:..|....|.....: |.::||          :||:..|||
Zfish   211 VTAQ---------VDREEKEVYHLDIVCMVRT-ERNLEEVFRSLHVNIYDEDDNSPYV------- 258

  Fly   352 PIRPGGLTIKAAEGDDDHPRVLEVSVAQST---TPTITTTSTTPAPVSSTRPTASTRRPLTPVER 413
                        .|.|....::|...::.|   |..:....|||     ..||...:..|.....
Zfish   259 ------------NGTDTEDVLVEFDRSEGTVFGTLFVYDRDTTP-----VYPTNQVQNKLVGTLM 306

  Fly   414 SRSKY-------KYHMRERGLVPTAAPPPAAPPAPPVSRTRYVGSGRPTAGLSDSIQDLKQTESE 471
            :...:       ::..||...:                    .|:.|.|      :.:.|
Zfish   307 TNDSWIKNNFAIEHKFREEKAI--------------------FGNVRGT------VHEYK----- 340

  Fly   472 VAKPVVRRVVQKVSPSSSTPLIITVLSAEEETTVGQTEALPTDESTTTTSTTTTTEKPSTTTSTS 536
                  .::.|.:|.:.....::..|                      .:.||......|.....
Zfish   341 ------LKLSQNLSVTEQRSFLLGYL----------------------VNDTTFPGPEGTVLLHF 377

  Fly   537 TTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKELI 601
            ..|..|||.    ..:|...|.|.:...||.|........:......|..|.:...:........
Zfish   378 NVTVLPVPI----RFSNVTYSFTVSQKATTYSQIGKVCVENCQKFKGIDVTYQLEIVDRNITAEA 438

  Fly   602 RALGPALTREINIDDANNLIVFCNNTSDCGVTPRTQTQPSH----TTDSSPKILRTTVLT----- 657
            ::...|::...|.:| |..:::.|:|.   |..|.:.|...    ..:...|:...|.||
Zfish   439 QSCYWAVSLAQNPND-NTGVLYVNDTK---VLRRPECQELEYVVIAQEQQNKLQAKTQLTVSFQG 499

  Fly   658 ---SIRSTVHPR---------------------PT---------STSTTTSTTTTAPPAVTAPSN 689
               |:: |..||                     ||         ....:...:|.:|...|.|..
Zfish   500 EADSLK-TDEPRFPACAEKRQRGDCEATRGLGAPTGRCQWRQGRDKGISKRYSTCSPNLGTCPDG 563

  Fly   690 EVYIGIVESSS-SASPADISSTVIAN--ERDL----------------------NMEMRRMNLVT 729
              |...:||.: |..|.|.||..|..  ||||                      ..|....|.:.
Zfish   564 --YCDAIESKNISICPQDCSSEAIIGGYERDLYGIKAGHGTCYCFEGKCFCERDEPEDDICNDMC 626

  Fly   730 LVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDH 794
            ..::|.|:| |:.|:..|:.::.|.|..|.:           |..|:...:..::
Zfish   627 KTVIATGII-LSFIVSVLLSSYFIHRYHKTT-----------PKPPIASAEMTFR---------- 669

  Fly   795 QHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFH------------ 847
                              :..|:.|:|.::          ||..:.||.|..:
Zfish   670 ------------------RPAQSYPISYSA----------NNVRRASLDSMENQVAIDTFKIPED 706

  Fly   848 ---DFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVSLKD---EANI 906
               :|.|.|:.|...||||.||:|.||.|..|.|..|.| .||||.::..::...|:|   |..:
Zfish   707 PKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYT-TVAVKMLKENASHSELRDLLSEFTL 770

  Fly   907 MRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSA----------TNILPASVPG 961
            :::: :|.:|:.:.|||.:..|..||:|||..|.|.:.||.:|..          .|......|.
Zfish   771 LKQV-NHPHVIKMYGACSQDGPLYLIVEYAKYGSLRNFLRESRKVGPSYMGNDANRNSSYLENPD 834

  Fly   962 GRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERM 1026
            .|:   |:...|..||..|:.||:|:|..::|||||||||||:......||.|||:|.|:..|
Zfish   835 ERA---LTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEE-- 894

  Fly  1027 RKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIG 1091
                                     ..|:                         |:|
Zfish   895 -------------------------DSYV-------------------------KRS-------- 901

  Fly  1092 KRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLP 1156
             :..:|::|||.|||..|::||::|:|:||::||||.|||..||..:....:...:..|.|.:.|
Zfish   902 -KGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKP 965

  Fly  1157 KESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVS 1209
            :....|.||||.|||.:|...||:|:....|:.:.:.|       :.||:|::
Zfish   966 ENCTDEMYNLMLRCWKQESDKRPTFSDISKELEKMMVK-------SRDYLDLA 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	110/341 (32%)
ret	NP_858048.2	RET_CLD1	23..140	CDD:465485	7/45 (16%)
		CA	186..256	CDD:214520	16/92 (17%)
		RET_CLD3	251..364	CDD:465516	25/195 (13%)
		RET_CLD4	388..499	CDD:465517	21/114 (18%)
		PTKc_RET	715..1004	CDD:173631	113/361 (31%)