Protein Alignment Tie and kita

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: XP_009292910.1
• Gene: kita / 30256
• ZFINID: ZDB-GENE-980526-464
• Length: 981
• Species: Danio rerio
• Alignment Length: 1144
• Identity: 245/1144 - (21%)
• Similarity: 397/1144 - (34%)
• Gaps: 399/1144 - (34%)

  Fly   247 CANFTRMAMPSNGNSSVVLKGSASLKAAAPAGDRDTNEILFSDESSH---GLFVVAKEQNGTLNH 308
            |..||.:.       .::::...|.....|.|.|.|.. |:|:.|.|   ...|..:.:|..:..
Zfish     5 CVLFTVLL-------QLIIQPGRSRPTITPEGPRLTVP-LYSNFSLHCQSNSTVRWQHENRPMRT 61

  Fly   309 IADGTK-------------PAVMGKGIPSKTNSMEDDVEEEEDELKPYVYFGAKL--PPIRPGGL 358
            :.:..:             |..:||      .|..::...|:..:  |||..|.|  .|..|...
Zfish    62 LKEEQRQGQQTILKVNRAGPQHLGK------YSCREEKTGEKSSI--YVYVKAFLSADPENPFRR 118

  Fly   359 TIKAAEGDDDHPRVLEVSVAQSTTPTITTTSTTP------------APV-SSTRPTASTRRPLTP 410
            ||           |.::..|:..|..|...:|.|            .|: :|.|.:||....::
Zfish   119 TI-----------VFDIVAAEGDTTVIPCLATDPDMKNLNLQKCDGQPLPNSLRYSASLETGVS- 171

  Fly   411 VERSRSKY------------------KYHMRERGLVPTAAPPPAAPPAPPVSRTRYVGSGRPTAG 457
            ||:.|.::                  :|.:..| |||.|.||              :..|:|
Zfish   172 VEKVRKEFEGCYVCVGTLDAATVKSGRYQLTVR-LVPDAPPP--------------ITLGQP--- 218

  Fly   458 LSDSIQDLKQTESEVAKPVVRRVVQKVSPSSSTPLIITVLSAEEET------TVGQTEALPTDES 516
                 |.:..|:.|           |:|.|.||..:.:.::.:.:.      :|.|...|.|:..
Zfish   219 -----QRVLLTQGE-----------KLSLSCSTSNVNSDIAVKWKAPNGVNPSVHQNSHLLTEPI 267

  Fly   517 T-------TTTSTTT---------------TTEKP------------STTTSTSTTTTTPVPSTS 547
            |       :.:|.|.               ||.||            .|:...||.......|.|
Zfish   268 THVRTAILSLSSVTMQDAGNYSCEAINEKGTTAKPVWVNIYEKGFINITSVDNSTRRVRAGESLS 332

  Fly   548 KRTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPALTREI 612
            .|...||      .|...|.|.:.|....::|:..||.:.|..||...:.| |:|         :
Zfish   333 LRVVMNA------YPKPHTFSWSYSGVKLTNTTDHVITSRTHGNSYTSELK-LVR---------L 381

  Fly   613 NIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTDSSPKIL--RTTVLTSIRSTVHPRPT------- 668
            .:.::......|.|..   .|.| ||...|.. |.|:|:  ...:...:|......||
Zfish   382 KVSESGIYTFSCLNRD---ATIR-QTFEVHVI-SKPQIVSYEGPIDGQVRCVAEGYPTPQIKWYY 441

  Fly   669 ----------------STSTTTSTTTTAPP----AVTAPSN--EVYIGIVESSSSASPADISSTV 711
                            ......:.|.|.||    ||.:..|  :.....:|..:||:...:.:..
Zfish   442 CDLPHSRCSNLLNATQEEEDVVTVTMTNPPFGKGAVESRLNITKNNYATLECVASANGEIVYTLF 506

  Fly   712 IANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPV 776
            ..:|..:..|:....|:..|..||.::.:..::.|...                    |:|
Zfish   507 SISENTVPHELFTPLLIGFVAAAVILVLILIVLTYKYM--------------------QKP---- 547

  Fly   777 KKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNN---DD 838
                 |||:                                       |.......:|||   .|
Zfish   548 -----KYQI---------------------------------------QWKVIEGIHGNNYVYID 568

  Fly   839 KTSLASEFH-DFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRA---CSAQVS 899
            .|.|..:.. :|.|..:|....||.|.||:|.:|.|..:| .......||||.::.   .:.:.:
Zfish   569 PTQLPYDHQWEFPRDKLRFGKTLGSGAFGKVVEATAYGMS-KADTVMTVAVKMLKPSAHATEKEA 632

  Fly   900 LKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAAR------------SAT 952
            |..|..::..||:|.|:|.|||||....|.::|.||...|.||:.||..|            ...
Zfish   633 LMSELKVLSYLGNHINIVNLLGACTVGGPTLVITEYCCFGDLLNFLRRRRVYFYYTTLGEDAYYR 697

  Fly   953 NILPASVP-----GGRSLAP------------------------------------LSPRTLAGF 976
            |::..|.|     |..::.|                                    |....|..|
Zfish   698 NVMMQSEPNDSRNGYMTMKPSVLGILSSENRRSLNKGDSYSDSDAVSEILQEDGLTLDTEDLLSF 762

  Fly   977 ALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRH 1041
            :..:|.||:::|.:..:||||||||:||....:.||||||::.|:..:          :|.:::.
Zfish   763 SYQVAKGMDFLASKNCIHRDLAARNILLTQGRVAKICDFGLARDITTD----------SNYVVKG 817

  Fly  1042 NAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESL 1106
            ||.                                                   ||::||:|||:
Zfish   818 NAR---------------------------------------------------LPVKWMSPESI 831

  Fly  1107 QYHMFTTETDIWAFGIVLWEIATLGSTPYSQL-TGREVIRRVPQGLRPDLPKESRHEFYNLMSRC 1170
            ...::|.|:|:|::||:||||.:|||:||..: ...:..:.:.:|.|.:.|:.|..|.|::|..|
Zfish   832 FECVYTFESDVWSYGILLWEIFSLGSSPYPGMPVDSKFYKMIKEGYRMESPEFSPSEMYDIMHSC 896

  Fly  1171 WHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVS 1209
            |..:|..||||::...:|.:.:     .||....|::.|
Zfish   897 WDADPVKRPSFSKIVEKIEQQI-----SDSTKHIYLNFS 930

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	104/385 (27%)
		PTKc	860..1187	CDD:270623	103/383 (27%)
kita	XP_009292910.1	IG_like	123..203	CDD:214653	14/80 (18%)
		IG_like	218..307	CDD:214653	20/107 (19%)
		ig	218..297	CDD:278476	16/97 (16%)
		Ig	311..410	CDD:299845	28/119 (24%)
		IG_like	325..408	CDD:214653	24/102 (24%)
		PTKc_Kit	549..918	CDD:270682	116/469 (25%)
		Pkinase_Tyr	585..914	CDD:285015	104/390 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900