DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tie and Srms

DIOPT Version :9

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_001011961.1 Gene:Srms / 296472 RGDID:1306602 Length:507 Species:Rattus norvegicus


Alignment Length:357 Identity:107/357 - (29%)
Similarity:161/357 - (45%) Gaps:91/357 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   842 LASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVSLKDEANI 906
            ||.:..:..||...|:..||||.||:||:       |.:..:..||||.|:  ||.:.|.|....
  Rat   233 LAQDEWERPRSEFVLRRKLGEGFFGEVWE-------GLWLGSTPVAVKVIK--SADMKLADLTKE 288

  Fly   907 MRKLGS--HQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLS 969
            :..|.|  |:.::.|...|...||..::.|...:|.|...|.:            |.|::   ||
  Rat   289 IEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYLGS------------PEGKA---LS 338

  Fly   970 PRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNA 1034
            ...|.|||..:|.||.|:..||:|||||||||||:..:..||:.|||::      |:.|:...:.
  Rat   339 LPHLLGFACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLA------RLLKDDVYSP 397

  Fly  1035 ANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIR 1099
            ::              ||:                                          :|::
  Rat   398 SS--------------GSK------------------------------------------IPVK 406

  Fly  1100 WMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFY 1164
            |.|||:..|.:|:.::|:|:|||:|:|:.|.|..||..:|..|.::::.:|.|...|.....|.|
  Rat   407 WTAPEAANYRVFSQKSDVWSFGILLYEVFTYGQCPYEGMTNHETLQQISRGYRLPRPAVCPAEVY 471

  Fly  1165 NLMSRCWHKEPHMRPSFAQSRLE---ITRSLH 1193
            .||..||...|..||:||..|.:   |.|.||
  Rat   472 MLMVECWKGSPEERPTFATLREKLNAINRRLH 503

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 97/330 (29%)
PTKc 860..1187 CDD:270623 98/328 (30%)
SrmsNP_001011961.1 SH3 70..124 CDD:302595
SH2 134..212 CDD:301589
PTKc_Srm_Brk 238..498 CDD:133248 101/345 (29%)
Pkinase_Tyr 245..495 CDD:285015 99/335 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D539311at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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