DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and Pdgfra

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_036934.1	Gene:	Pdgfra / 25267	RGDID:	3284	Length:	1088	Species:	Rattus norvegicus

Alignment Length:	1190	Identity:	247/1190 - (20%)
Similarity:	388/1190 - (32%)	Gaps:	420/1190 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 RMAMPS---NGNSSVV-LKGSASLKAAAP---------AGDRDTNEILFSDESSHGLFVVAKE-Q 302
            ::.:||   |.|..:| |..|.||:....         :.:.|.|..:.::|::..|||...| .
  Rat    23 QLLLPSILPNENEKIVPLSSSFSLRCFGESEVSWQHPMSEEEDPNVEIRTEENNSSLFVTVLEVV 87

  Fly   303 NGTLNHIADGTKPAVMGKGIPSKTNSMEDDVEEEEDELKP---YVYFGAKLPPIRPGGLT--IKA 362
            |.:..|....|              ...:..:.||.|::.   |:|.........|.|:|  :..
  Rat    88 NASAAHTGWYT--------------CYYNHTQTEESEIEGRHIYIYVPDPDMAFVPLGMTDSLVI 138

  Fly   363 AEGDDDHPRVLEVSVAQSTTPTITTTSTTPAPVSSTRPTASTRRPLTPVERSRSKYKYHMRERGL 427
            .|.||              :..|...:|.|    .|..|......|.|.       .|..|: |.
  Rat   139 VEEDD--------------SAIIPCRTTDP----DTEVTLHNNGRLVPA-------SYDSRQ-GF 177

  Fly   428 VPTAAPPPAAPPAPPVSRTRYVGS----GRPTAGLSDSIQDLKQTESEVAKPVVRRVVQKVSPSS 488
            ..|.:..|            |:..    ||.......::..||.|.....:...|:.|.|...:
  Rat   178 NGTFSVGP------------YICEATVRGRTFKTSEFNVYALKATSELNLEMDTRQTVYKAGET- 229

  Fly   489 STPLIITVLSAEEET----------------TVGQTEALPTDESTTTTSTTTTTEKPSTTTSTST 537
               :::|......|.                |:.:...||:.:...|.:....|.|.|.....:.
  Rat   230 ---IVVTCAVFNNEVVDLQWTYPGEVRNKGITMLEEIKLPSIKLVYTLTVPKATVKDSGDYECAA 291

  Fly   538 TTTTPVPSTSKRTT-------------TNAPLSTTNT------PTTTTSSTTPSTTTTSSTSTTV 583
            ...|......|..|             |...|.|.|.      .....:..||..:.... :.|:
  Rat   292 RQATKEVKEMKTVTISVHEKGFVQIRPTFGHLETVNLHQVREFVVEVQAYPTPRISWLKD-NLTL 355

  Fly   584 IPTTTKANSIIEKDKE--------LIRALGPALTREINIDDANNLIVFCNNTSDCGVTPRTQTQP 640
            |...|:..:.:::.:|        ||||      :|   :|:.:..:...|..|         ..
  Rat   356 IENLTEITTDVQRSQETRYQSKLKLIRA------KE---EDSGHYTIIVQNDDD---------MK 402

  Fly   641 SHTTDSSPKILRTTVLTSIRSTVHPRPTS----TSTTTSTTTTAP-------PAVTAPSNEVYIG 694
            |:|.:     |.|.|..||...|.....|    |...|:..|..|       ..:...:|:....
  Rat   403 SYTFE-----LSTLVPASILELVDDHHGSGGGQTVRCTAEGTPLPNIEWMICKDIKKCNNDTSWT 462

  Fly   695 IVESSSS-----------------ASPADISSTVIAN---ERDLNMEMRRMNLVT------LVLV 733
            ::.|:.|                 .|.|.:..|:...   :.||.:..|.:.||.      |.:.
  Rat   463 VLASNVSNIITEFHQRGRSTVEGRVSFAKVEETIAVRCLAKNDLGIGNRELKLVAPTLRSELTVA 527

  Fly   734 AVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQ 798
            |..::.|..:|:.|:...||   .||...:::.....:.|||
  Rat   528 AAVLVLLVIVIVSLIVLVVI---WKQKPRYEIRWRVIESISP----------------------- 566

  Fly   799 HMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEG 863
                       ..|::....||.....     :|:              :|.|..:.|..:||.|
  Rat   567 -----------DGHEYIYVDPMQLPYD-----SRW--------------EFPRDGLVLGRILGSG 601

  Fly   864 NFGQVWKAEADDLSGHFGATRI-----VAVKTIR---ACSAQVSLKDEANIMRKLGSHQNVVTLL 920
            .||:|.:..|      :|.:|.     ||||.::   ..|.:.:|..|..||..||.|.|:|.||
  Rat   602 AFGKVVEGTA------YGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLL 660

  Fly   921 GACVESEPHMLIMEYAMRGRLLSLLRAAR------------------------------------ 949
            |||.:|.|..:|.||...|.|::.|...|
  Rat   661 GACTKSGPIYIITEYCFYGDLVNYLHKNRDSFMSRHPEKPKKDLDIFGLNPADESTRSYVILSFE 725

  Fly   950 --------------------------------------------------SATNILPASVPGGRS 964
                                                              .|.|:|......|.:
  Rat   726 NNGDYVDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEAKNLLSDDDSEGLT 790

  Fly   965 LAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKE 1029
            |.     .|..|...:|.|||::|.:..||||||||||||....:.||||||:
  Rat   791 LL-----DLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGL------------ 838

  Fly  1030 QEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRH 1094
                 |.|:|..:.:..|   ||.:
  Rat   839 -----ARDIMHDSNYVSK---GSTF---------------------------------------- 855

  Fly  1095 ALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPY-SQLTGREVIRRVPQGLRPDLPKE 1158
             ||::||||||:..:::||.:|:|::|::||||.:||.||| ..:.......::..|.|...|..
  Rat   856 -LPVKWMAPESIFDNLYTTLSDVWSYGVLLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDH 919

  Fly  1159 SRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSL--------HKWVDDDSAASDYMDVSGFSEDL 1215
            :..|.|.:|.:||:.||..||||.... ||..:|        ::.:..|...||:..|:....|.
  Rat   920 ATSEVYEIMVQCWNSEPEKRPSFYHLS-EIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDS 983

  Fly  1216 EH---GVVYFNH--RISEFE 1230
            ::   ||.|.|.  ::.|:|
  Rat   984 DNAYIGVTYKNEEDKLKEWE 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	110/423 (26%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	109/421 (26%)
Pdgfra	NP_036934.1	Ig_3	27..99	CDD:404760	19/85 (22%)
		Ig	211..309	CDD:416386	15/101 (15%)
		Ig strand A	211..215	CDD:409353	0/3 (0%)
		Ig strand A'	222..226	CDD:409353	1/3 (33%)
		Ig strand B	228..237	CDD:409353	1/12 (8%)
		Ig strand C	242..247	CDD:409353	0/4 (0%)
		Ig strand C'	250..252	CDD:409353	0/1 (0%)
		Ig strand D	256..264	CDD:409353	1/7 (14%)
		Ig strand E	268..276	CDD:409353	1/7 (14%)
		Ig strand F	286..292	CDD:409353	0/5 (0%)
		Ig strand G	297..303	CDD:409353	0/5 (0%)
		Ig4_PDGFR	312..412	CDD:409445	22/123 (18%)
		Ig strand B	332..336	CDD:409445	0/3 (0%)
		Ig strand C	345..349	CDD:409445	0/3 (0%)
		Ig strand E	376..380	CDD:409445	0/3 (0%)
		Ig strand F	390..395	CDD:409445	0/4 (0%)
		Ig strand G	403..406	CDD:409445	1/2 (50%)
		PTKc_PDGFR_alpha	554..955	CDD:173653	122/526 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1017..1088
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000